The prevalence of esophageal cancer after caustic and pesticide ingestion: A nationwide cohort study
Habits such as smoking and alcohol drinking and existing esophageal malfunction are considered the main risk factors for esophageal carcinogenesis. Caustic ingestion of acidic or alkaline agents or strong irritants can induce severe esophageal corrosive injury and increase esophageal cancer risk. We...
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| description | Habits such as smoking and alcohol drinking and existing esophageal malfunction are considered the main risk factors for esophageal carcinogenesis. Caustic ingestion of acidic or alkaline agents or strong irritants can induce severe esophageal corrosive injury and increase esophageal cancer risk. We studied the relationship between esophageal carcinoma and acute detergent or pesticide poisoning by using nationwide health insurance data. Methodology/Principle findings: We compared a pesticide/detergent intoxication cohort (N = 21,840) and an age- and gender-matched control cohort (N = 21,840) identified from the National Health Insurance Research Database between 2000 and 2011. We used the multivariable Cox proportional model to determine esophageal carcinoma risk. The overall incidence density of esophageal cancer was 1.66 per 10,000 person-years in the comparison cohort and 4.36 per 10,000 person-years in the pesticide/detergent intoxication cohort. The corresponding adjusted hazard ratio (HR) for esophageal cancer was 2.33 (95% confidence interval [CI] = 1.41-3.86) in the pesticide/detergent intoxication cohort compared with the control cohort. Patients with corrosive and detergent intoxication did not have a higher risk of esophageal cancer (adjusted HR = 0.98, 95% CI = 0.29-3.33) than those without pesticide/detergent intoxication. However, patients with pesticide intoxication had a significantly higher risk of esophageal cancer (adjusted HR = 2.52, 95% CI = 1.52-4.18) than those without pesticide/detergent intoxication. Conclusion: In the present study, after adjusting for conventional risk factors, we observed that pesticide intoxication could exert substantial effects through increased esophageal cancer risk. However, patients with detergent intoxication may not have an increased risk of esophageal cancer. |
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Caustic ingestion of acidic or alkaline agents or strong irritants can induce severe esophageal corrosive injury and increase esophageal cancer risk. We studied the relationship between esophageal carcinoma and acute detergent or pesticide poisoning by using nationwide health insurance data. Methodology/Principle findings: We compared a pesticide/detergent intoxication cohort (N = 21,840) and an age- and gender-matched control cohort (N = 21,840) identified from the National Health Insurance Research Database between 2000 and 2011. We used the multivariable Cox proportional model to determine esophageal carcinoma risk. The overall incidence density of esophageal cancer was 1.66 per 10,000 person-years in the comparison cohort and 4.36 per 10,000 person-years in the pesticide/detergent intoxication cohort. The corresponding adjusted hazard ratio (HR) for esophageal cancer was 2.33 (95% confidence interval [CI] = 1.41-3.86) in the pesticide/detergent intoxication cohort compared with the control cohort. Patients with corrosive and detergent intoxication did not have a higher risk of esophageal cancer (adjusted HR = 0.98, 95% CI = 0.29-3.33) than those without pesticide/detergent intoxication. However, patients with pesticide intoxication had a significantly higher risk of esophageal cancer (adjusted HR = 2.52, 95% CI = 1.52-4.18) than those without pesticide/detergent intoxication. Conclusion: In the present study, after adjusting for conventional risk factors, we observed that pesticide intoxication could exert substantial effects through increased esophageal cancer risk. However, patients with detergent intoxication may not have an increased risk of esophageal cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0243922</identifier><identifier>PMID: 33373373</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Aged ; Alcohol ; Biology and Life Sciences ; Cancer ; Carcinogenesis ; Carcinogens ; Carcinoma - chemically induced ; Carcinoma - epidemiology ; Carcinoma - pathology ; Cardiovascular disease ; Causes of ; Caustics - poisoning ; Cerebrovascular disease ; Chronic obstructive pulmonary disease ; Codes ; Cohort analysis ; Cohort Studies ; Comorbidity ; Complications and side effects ; Confidence intervals ; Corrosion prevention ; Detergents - poisoning ; Detergents, Synthetic ; Diabetes ; Drinking behavior ; Eating - drug effects ; Emergency medical care ; Esophageal cancer ; Esophageal carcinoma ; Esophageal Neoplasms - chemically induced ; Esophageal Neoplasms - epidemiology ; Esophageal Neoplasms - pathology ; Esophagus ; Female ; Health aspects ; Health insurance ; Health risks ; Hospitals ; Humans ; Hypertension ; Illnesses ; Ingestion ; Insurance ; Intoxication ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Pesticides ; Pesticides - poisoning ; Physical Sciences ; Poisoning ; Proportional Hazards Models ; Risk analysis ; Risk Factors ; Statistics ; Surfactants ; Toxicology</subject><ispartof>PloS one, 2020-12, Vol.15 (12), p.e0243922</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Mu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Mu et al 2020 Mu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-c223027c30b7c554c7a177543dfff92a405aaf929f3806565bd2925728c30fea3</citedby><cites>FETCH-LOGICAL-c692t-c223027c30b7c554c7a177543dfff92a405aaf929f3806565bd2925728c30fea3</cites><orcidid>0000-0002-7449-0327 ; 0000-0002-5131-8786</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771858/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771858/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33373373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mu, Han-Wei</creatorcontrib><creatorcontrib>Chen, Chun-Hung</creatorcontrib><creatorcontrib>Yang, Kai-Wei</creatorcontrib><creatorcontrib>Pan, Chi-Syuan</creatorcontrib><creatorcontrib>Lin, Cheng-Li</creatorcontrib><creatorcontrib>Hung, Dong-Zong</creatorcontrib><title>The prevalence of esophageal cancer after caustic and pesticide ingestion: A nationwide cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Habits such as smoking and alcohol drinking and existing esophageal malfunction are considered the main risk factors for esophageal carcinogenesis. Caustic ingestion of acidic or alkaline agents or strong irritants can induce severe esophageal corrosive injury and increase esophageal cancer risk. We studied the relationship between esophageal carcinoma and acute detergent or pesticide poisoning by using nationwide health insurance data. Methodology/Principle findings: We compared a pesticide/detergent intoxication cohort (N = 21,840) and an age- and gender-matched control cohort (N = 21,840) identified from the National Health Insurance Research Database between 2000 and 2011. We used the multivariable Cox proportional model to determine esophageal carcinoma risk. The overall incidence density of esophageal cancer was 1.66 per 10,000 person-years in the comparison cohort and 4.36 per 10,000 person-years in the pesticide/detergent intoxication cohort. The corresponding adjusted hazard ratio (HR) for esophageal cancer was 2.33 (95% confidence interval [CI] = 1.41-3.86) in the pesticide/detergent intoxication cohort compared with the control cohort. Patients with corrosive and detergent intoxication did not have a higher risk of esophageal cancer (adjusted HR = 0.98, 95% CI = 0.29-3.33) than those without pesticide/detergent intoxication. However, patients with pesticide intoxication had a significantly higher risk of esophageal cancer (adjusted HR = 2.52, 95% CI = 1.52-4.18) than those without pesticide/detergent intoxication. Conclusion: In the present study, after adjusting for conventional risk factors, we observed that pesticide intoxication could exert substantial effects through increased esophageal cancer risk. However, patients with detergent intoxication may not have an increased risk of esophageal cancer.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Alcohol</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Carcinoma - chemically induced</subject><subject>Carcinoma - epidemiology</subject><subject>Carcinoma - pathology</subject><subject>Cardiovascular disease</subject><subject>Causes of</subject><subject>Caustics - poisoning</subject><subject>Cerebrovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Codes</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Complications and side effects</subject><subject>Confidence intervals</subject><subject>Corrosion prevention</subject><subject>Detergents - poisoning</subject><subject>Detergents, Synthetic</subject><subject>Diabetes</subject><subject>Drinking behavior</subject><subject>Eating - drug effects</subject><subject>Emergency medical care</subject><subject>Esophageal cancer</subject><subject>Esophageal carcinoma</subject><subject>Esophageal Neoplasms - chemically induced</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagus</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health insurance</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Illnesses</subject><subject>Ingestion</subject><subject>Insurance</subject><subject>Intoxication</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Pesticides</subject><subject>Pesticides - poisoning</subject><subject>Physical Sciences</subject><subject>Poisoning</subject><subject>Proportional Hazards Models</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Statistics</subject><subject>Surfactants</subject><subject>Toxicology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkmuL1DAUhoso7kX_gWhAWPDDjLk0SesHYVi8DCws6OrXcJombYdOU5N2df-9qdNdpqAgLe3L6XPetue8SfKC4DVhkrzdudF30K5715k1pinLKX2UnJKc0ZWgmD0-0ifJWQg7jDnLhHianDDG5HSeJuVNbVDvzS20ptMGOYtMcH0NlYEWaYg1j8AO8aphDEOjEXQl6s0km9Kgpqsm7bp3aIM6mNTPqa5d7fyAwjCWd8-SJxbaYJ7P9_Pk28cPN5efV1fXn7aXm6uVFjkdVppShqnUDBdSc55qCURKnrLSWptTSDEHiCK3LMOCC16UNKdc0iy2WAPsPHl18O1bF9Q8oKBoKpmkMpNpJLYHonSwU71v9uDvlING_Sk4Xynw8c9ao1hZCLCGCY5JajQrdG4yyQSxkkjLdfR6P79tLPam1KYbPLQL0-WTrqlV5W6VlJJkPIsGr2cD736McYr_-OSZquKKVNNZF830vglabUQqcjltPlLrv1DxKM2-0TEiton1RcObRUNkBvNrqOKSg9p-_fL_7PX3JXtxxNYxRUMdXDtOwQhLMD2A2rsQvLEPkyNYTQm_n4aaEq7mhMe2l8dTf2i6jzT7DSu_9qc</recordid><startdate>20201229</startdate><enddate>20201229</enddate><creator>Mu, Han-Wei</creator><creator>Chen, Chun-Hung</creator><creator>Yang, Kai-Wei</creator><creator>Pan, Chi-Syuan</creator><creator>Lin, Cheng-Li</creator><creator>Hung, Dong-Zong</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7449-0327</orcidid><orcidid>https://orcid.org/0000-0002-5131-8786</orcidid></search><sort><creationdate>20201229</creationdate><title>The prevalence of esophageal cancer after caustic and pesticide ingestion: A nationwide cohort study</title><author>Mu, Han-Wei ; Chen, Chun-Hung ; Yang, Kai-Wei ; Pan, Chi-Syuan ; Lin, Cheng-Li ; Hung, Dong-Zong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-c223027c30b7c554c7a177543dfff92a405aaf929f3806565bd2925728c30fea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Alcohol</topic><topic>Biology and Life Sciences</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Carcinoma - 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Caustic ingestion of acidic or alkaline agents or strong irritants can induce severe esophageal corrosive injury and increase esophageal cancer risk. We studied the relationship between esophageal carcinoma and acute detergent or pesticide poisoning by using nationwide health insurance data. Methodology/Principle findings: We compared a pesticide/detergent intoxication cohort (N = 21,840) and an age- and gender-matched control cohort (N = 21,840) identified from the National Health Insurance Research Database between 2000 and 2011. We used the multivariable Cox proportional model to determine esophageal carcinoma risk. The overall incidence density of esophageal cancer was 1.66 per 10,000 person-years in the comparison cohort and 4.36 per 10,000 person-years in the pesticide/detergent intoxication cohort. The corresponding adjusted hazard ratio (HR) for esophageal cancer was 2.33 (95% confidence interval [CI] = 1.41-3.86) in the pesticide/detergent intoxication cohort compared with the control cohort. Patients with corrosive and detergent intoxication did not have a higher risk of esophageal cancer (adjusted HR = 0.98, 95% CI = 0.29-3.33) than those without pesticide/detergent intoxication. However, patients with pesticide intoxication had a significantly higher risk of esophageal cancer (adjusted HR = 2.52, 95% CI = 1.52-4.18) than those without pesticide/detergent intoxication. Conclusion: In the present study, after adjusting for conventional risk factors, we observed that pesticide intoxication could exert substantial effects through increased esophageal cancer risk. However, patients with detergent intoxication may not have an increased risk of esophageal cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33373373</pmid><doi>10.1371/journal.pone.0243922</doi><tpages>e0243922</tpages><orcidid>https://orcid.org/0000-0002-7449-0327</orcidid><orcidid>https://orcid.org/0000-0002-5131-8786</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Alcohol Biology and Life Sciences Cancer Carcinogenesis Carcinogens Carcinoma - chemically induced Carcinoma - epidemiology Carcinoma - pathology Cardiovascular disease Causes of Caustics - poisoning Cerebrovascular disease Chronic obstructive pulmonary disease Codes Cohort analysis Cohort Studies Comorbidity Complications and side effects Confidence intervals Corrosion prevention Detergents - poisoning Detergents, Synthetic Diabetes Drinking behavior Eating - drug effects Emergency medical care Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - chemically induced Esophageal Neoplasms - epidemiology Esophageal Neoplasms - pathology Esophagus Female Health aspects Health insurance Health risks Hospitals Humans Hypertension Illnesses Ingestion Insurance Intoxication Male Medicine Medicine and Health Sciences Middle Aged Pesticides Pesticides - poisoning Physical Sciences Poisoning Proportional Hazards Models Risk analysis Risk Factors Statistics Surfactants Toxicology |
| title | The prevalence of esophageal cancer after caustic and pesticide ingestion: A nationwide cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T17%3A07%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20prevalence%20of%20esophageal%20cancer%20after%20caustic%20and%20pesticide%20ingestion:%20A%20nationwide%20cohort%20study&rft.jtitle=PloS%20one&rft.au=Mu,%20Han-Wei&rft.date=2020-12-29&rft.volume=15&rft.issue=12&rft.spage=e0243922&rft.pages=e0243922-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0243922&rft_dat=%3Cgale_plos_%3EA646974392%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2473727874&rft_id=info:pmid/33373373&rft_galeid=A646974392&rft_doaj_id=oai_doaj_org_article_3db6afe365014ec3bc9e87361f717f5c&rfr_iscdi=true |