Risk factors associated with weight gain after kidney transplantation: A cohort study
Renal transplantation is the best modality of renal replacement therapy for patients with end-stage renal disease. However, it is associated with weight gain and metabolic abnormalities, which adversely impact transplant outcomes. The objective of this study was to identify the risk factors of one-y...
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| Veröffentlicht in: | PloS one 2020-12, Vol.15 (12), p.e0243394-e0243394 |
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| creator | Forte, Cristina Carra Pedrollo, Elis Forcellini Nicoletto, Bruna Bellincanta Lopes, Jéssica Blatt Manfro, Roberto Ceratti Souza, Gabriela Corrêa Leitão, Cristiane Bauermann |
| description | Renal transplantation is the best modality of renal replacement therapy for patients with end-stage renal disease. However, it is associated with weight gain and metabolic abnormalities, which adversely impact transplant outcomes.
The objective of this study was to identify the risk factors of one-year weight gain after renal transplantation.
A retrospective cohort study was conducted with 374 patients that underwent kidney transplantation between January 2006 and July 2013. Clinical and laboratory variables were collected from electronic records, and the outcome of interest was weight gain during the first year after renal transplantation. The data were reported as mean ± standard deviation, median (interquartile range) or number of subjects (%). The association between variables were assessed via chi-square test and ANOVA. For analysis of risk factors related to the outcomes of interest, multivariable logistic regression models were used.
There were 181 (48.4%) female patients, 334 (89.3%) with white ethnicity and the mean age was 44.4 ± 12.8 years. The mean BMI pre-transplant was 24.7 ± 4.1 kg/m2, and 35 (9.9%) patients were classified as obese; 119 (33.6%) as overweight; 187 (52.8%) as normal weight; and 13 (3.7%) as malnourished. After one year of follow-up, the mean BMI was 26.2 ± 5.0 kg/m2, and 61 (17.3%) patients were classified as obese; 133 (37.8%) as overweight; 148 (42.0%) as normal weight; and 10 (2.8%) as malnourished. Weight gain was observed in 72.7% patients, and the average increase was 7.12 ± 5.9 kg. The female gender, lower pre-transplant body weight, lower number of hospitalizations, and a kidney received from a living donor were associated with weight gain by more than 5% in the first year post-transplant.
Female gender and lower pre-transplant body weight were independently associated with weight gain by more than 5% in the first year after kidney transplantation; lower rates of hospitalization and donation from living donors were also risk factors for this outcome. |
| doi_str_mv | 10.1371/journal.pone.0243394 |
| format | Article |
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The objective of this study was to identify the risk factors of one-year weight gain after renal transplantation.
A retrospective cohort study was conducted with 374 patients that underwent kidney transplantation between January 2006 and July 2013. Clinical and laboratory variables were collected from electronic records, and the outcome of interest was weight gain during the first year after renal transplantation. The data were reported as mean ± standard deviation, median (interquartile range) or number of subjects (%). The association between variables were assessed via chi-square test and ANOVA. For analysis of risk factors related to the outcomes of interest, multivariable logistic regression models were used.
There were 181 (48.4%) female patients, 334 (89.3%) with white ethnicity and the mean age was 44.4 ± 12.8 years. The mean BMI pre-transplant was 24.7 ± 4.1 kg/m2, and 35 (9.9%) patients were classified as obese; 119 (33.6%) as overweight; 187 (52.8%) as normal weight; and 13 (3.7%) as malnourished. After one year of follow-up, the mean BMI was 26.2 ± 5.0 kg/m2, and 61 (17.3%) patients were classified as obese; 133 (37.8%) as overweight; 148 (42.0%) as normal weight; and 10 (2.8%) as malnourished. Weight gain was observed in 72.7% patients, and the average increase was 7.12 ± 5.9 kg. The female gender, lower pre-transplant body weight, lower number of hospitalizations, and a kidney received from a living donor were associated with weight gain by more than 5% in the first year post-transplant.
Female gender and lower pre-transplant body weight were independently associated with weight gain by more than 5% in the first year after kidney transplantation; lower rates of hospitalization and donation from living donors were also risk factors for this outcome.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0243394</identifier><identifier>PMID: 33370293</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Adult ; Age ; Biology and Life Sciences ; Body Mass Index ; Body weight ; Body weight gain ; Care and treatment ; Chi-square test ; Chronic kidney failure ; Cohort analysis ; Cohort Studies ; Diabetes ; Donors (electronic) ; Drug dosages ; End-stage renal disease ; Endocrinology ; Ethnicity ; Female ; Gender ; Health aspects ; Health risks ; Hospitals ; Humans ; Hypertension ; Kidney diseases ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - therapy ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Kidney transplants ; Kidneys ; Male ; Mean ; Medical research ; Medicine ; Medicine and Health Sciences ; Metabolism ; Middle Aged ; Minority & ethnic groups ; Mortality ; Nephrology ; Nutrition ; Obesity ; Obesity - etiology ; Obesity - physiopathology ; Overweight ; Overweight - etiology ; Overweight - physiopathology ; Patient outcomes ; Patients ; Peritoneal dialysis ; Quality of life ; Regression analysis ; Regression models ; Retrospective Studies ; Risk analysis ; Risk Factors ; Statistical tests ; Transplantation ; Transplants & implants ; Variables ; Variance analysis ; Weight gain ; Weight Gain - physiology ; White People</subject><ispartof>PloS one, 2020-12, Vol.15 (12), p.e0243394-e0243394</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Forte et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Forte et al 2020 Forte et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-beda696d8144b39abe8db50c80e4f54fa730e30527ad8d9d3ec68b64e240b0fd3</citedby><cites>FETCH-LOGICAL-c692t-beda696d8144b39abe8db50c80e4f54fa730e30527ad8d9d3ec68b64e240b0fd3</cites><orcidid>0000-0002-9706-2173</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769456/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769456/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33370293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lombardo, Mauro</contributor><creatorcontrib>Forte, Cristina Carra</creatorcontrib><creatorcontrib>Pedrollo, Elis Forcellini</creatorcontrib><creatorcontrib>Nicoletto, Bruna Bellincanta</creatorcontrib><creatorcontrib>Lopes, Jéssica Blatt</creatorcontrib><creatorcontrib>Manfro, Roberto Ceratti</creatorcontrib><creatorcontrib>Souza, Gabriela Corrêa</creatorcontrib><creatorcontrib>Leitão, Cristiane Bauermann</creatorcontrib><title>Risk factors associated with weight gain after kidney transplantation: A cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Renal transplantation is the best modality of renal replacement therapy for patients with end-stage renal disease. However, it is associated with weight gain and metabolic abnormalities, which adversely impact transplant outcomes.
The objective of this study was to identify the risk factors of one-year weight gain after renal transplantation.
A retrospective cohort study was conducted with 374 patients that underwent kidney transplantation between January 2006 and July 2013. Clinical and laboratory variables were collected from electronic records, and the outcome of interest was weight gain during the first year after renal transplantation. The data were reported as mean ± standard deviation, median (interquartile range) or number of subjects (%). The association between variables were assessed via chi-square test and ANOVA. For analysis of risk factors related to the outcomes of interest, multivariable logistic regression models were used.
There were 181 (48.4%) female patients, 334 (89.3%) with white ethnicity and the mean age was 44.4 ± 12.8 years. The mean BMI pre-transplant was 24.7 ± 4.1 kg/m2, and 35 (9.9%) patients were classified as obese; 119 (33.6%) as overweight; 187 (52.8%) as normal weight; and 13 (3.7%) as malnourished. After one year of follow-up, the mean BMI was 26.2 ± 5.0 kg/m2, and 61 (17.3%) patients were classified as obese; 133 (37.8%) as overweight; 148 (42.0%) as normal weight; and 10 (2.8%) as malnourished. Weight gain was observed in 72.7% patients, and the average increase was 7.12 ± 5.9 kg. The female gender, lower pre-transplant body weight, lower number of hospitalizations, and a kidney received from a living donor were associated with weight gain by more than 5% in the first year post-transplant.
Female gender and lower pre-transplant body weight were independently associated with weight gain by more than 5% in the first year after kidney transplantation; lower rates of hospitalization and donation from living donors were also risk factors for this outcome.</description><subject>Abnormalities</subject><subject>Adult</subject><subject>Age</subject><subject>Biology and Life Sciences</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Care and treatment</subject><subject>Chi-square test</subject><subject>Chronic kidney failure</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Diabetes</subject><subject>Donors (electronic)</subject><subject>Drug dosages</subject><subject>End-stage renal disease</subject><subject>Endocrinology</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Gender</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - epidemiology</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney transplants</subject><subject>Kidneys</subject><subject>Male</subject><subject>Mean</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Obesity - etiology</subject><subject>Obesity - physiopathology</subject><subject>Overweight</subject><subject>Overweight - etiology</subject><subject>Overweight - physiopathology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Peritoneal dialysis</subject><subject>Quality of life</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Statistical tests</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Variables</subject><subject>Variance analysis</subject><subject>Weight gain</subject><subject>Weight Gain - 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complications</topic><topic>Kidney Failure, Chronic - epidemiology</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney transplants</topic><topic>Kidneys</topic><topic>Male</topic><topic>Mean</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Obesity - etiology</topic><topic>Obesity - physiopathology</topic><topic>Overweight</topic><topic>Overweight - etiology</topic><topic>Overweight - physiopathology</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Peritoneal dialysis</topic><topic>Quality of life</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Statistical tests</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Variables</topic><topic>Variance analysis</topic><topic>Weight gain</topic><topic>Weight Gain - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forte, Cristina Carra</au><au>Pedrollo, Elis Forcellini</au><au>Nicoletto, Bruna Bellincanta</au><au>Lopes, Jéssica Blatt</au><au>Manfro, Roberto Ceratti</au><au>Souza, Gabriela Corrêa</au><au>Leitão, Cristiane Bauermann</au><au>Lombardo, Mauro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors associated with weight gain after kidney transplantation: A cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-12-28</date><risdate>2020</risdate><volume>15</volume><issue>12</issue><spage>e0243394</spage><epage>e0243394</epage><pages>e0243394-e0243394</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Renal transplantation is the best modality of renal replacement therapy for patients with end-stage renal disease. However, it is associated with weight gain and metabolic abnormalities, which adversely impact transplant outcomes.
The objective of this study was to identify the risk factors of one-year weight gain after renal transplantation.
A retrospective cohort study was conducted with 374 patients that underwent kidney transplantation between January 2006 and July 2013. Clinical and laboratory variables were collected from electronic records, and the outcome of interest was weight gain during the first year after renal transplantation. The data were reported as mean ± standard deviation, median (interquartile range) or number of subjects (%). The association between variables were assessed via chi-square test and ANOVA. For analysis of risk factors related to the outcomes of interest, multivariable logistic regression models were used.
There were 181 (48.4%) female patients, 334 (89.3%) with white ethnicity and the mean age was 44.4 ± 12.8 years. The mean BMI pre-transplant was 24.7 ± 4.1 kg/m2, and 35 (9.9%) patients were classified as obese; 119 (33.6%) as overweight; 187 (52.8%) as normal weight; and 13 (3.7%) as malnourished. After one year of follow-up, the mean BMI was 26.2 ± 5.0 kg/m2, and 61 (17.3%) patients were classified as obese; 133 (37.8%) as overweight; 148 (42.0%) as normal weight; and 10 (2.8%) as malnourished. Weight gain was observed in 72.7% patients, and the average increase was 7.12 ± 5.9 kg. The female gender, lower pre-transplant body weight, lower number of hospitalizations, and a kidney received from a living donor were associated with weight gain by more than 5% in the first year post-transplant.
Female gender and lower pre-transplant body weight were independently associated with weight gain by more than 5% in the first year after kidney transplantation; lower rates of hospitalization and donation from living donors were also risk factors for this outcome.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33370293</pmid><doi>10.1371/journal.pone.0243394</doi><tpages>e0243394</tpages><orcidid>https://orcid.org/0000-0002-9706-2173</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-12, Vol.15 (12), p.e0243394-e0243394 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2473448756 |
| source | PLoS; MEDLINE; Full-Text Journals in Chemistry (Open access); Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Abnormalities Adult Age Biology and Life Sciences Body Mass Index Body weight Body weight gain Care and treatment Chi-square test Chronic kidney failure Cohort analysis Cohort Studies Diabetes Donors (electronic) Drug dosages End-stage renal disease Endocrinology Ethnicity Female Gender Health aspects Health risks Hospitals Humans Hypertension Kidney diseases Kidney Failure, Chronic - complications Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Kidney transplantation Kidney Transplantation - adverse effects Kidney transplants Kidneys Male Mean Medical research Medicine Medicine and Health Sciences Metabolism Middle Aged Minority & ethnic groups Mortality Nephrology Nutrition Obesity Obesity - etiology Obesity - physiopathology Overweight Overweight - etiology Overweight - physiopathology Patient outcomes Patients Peritoneal dialysis Quality of life Regression analysis Regression models Retrospective Studies Risk analysis Risk Factors Statistical tests Transplantation Transplants & implants Variables Variance analysis Weight gain Weight Gain - physiology White People |
| title | Risk factors associated with weight gain after kidney transplantation: A cohort study |
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