The role of the MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer

Despite the use of front-line anticancer drugs such as paclitaxel for ovarian cancer treatment, mortality rates have remained almost unchanged for the past three decades and the majority of patients will develop recurrent chemoresistant disease which remains largely untreatable. Overcoming chemoresi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0243715-e0243715
Hauptverfasser:	Bates, Mark, Spillane, Cathy D, Gallagher, Michael F, McCann, Amanda, Martin, Cara, Blackshields, Gordon, Keegan, Helen, Gubbins, Luke, Brooks, Robert, Brooks, Doug, Selemidis, Stavros, O'Toole, Sharon, O'Leary, John J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Antineoplastic drugs Antitumor agents Biological activity Biology and life sciences Biomarkers Biomarkers, Tumor - genetics Cancer therapies Care and treatment Cell division Cell Line, Tumor Cellular Senescence - genetics Chemoresistance Chromosomes Coagulation Collagenase 3 Cytokines Cytoskeleton Deoxyribonucleic acid Development and progression DNA DNA microarrays Drug development Drug resistance Drug Resistance, Neoplasm - genetics ErbB protein Extracellular matrix Female Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genotype & phenotype Growth factors Gynecology Health sciences Histopathology Hospitals Humans Insulin Ion transport Laboratories Ligands Mad2 Proteins - genetics Medical prognosis Medical research Medicine and Health Sciences MyD88 protein Myeloid Differentiation Factor 88 - genetics Obstetrics Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Packaging Paclitaxel Paclitaxel - pharmacology Paclitaxel - therapeutic use Pathology Patient outcomes Patients Pharmacy Phenotypes Prevention Research and Analysis Methods RNA, Small Interfering - metabolism Senescence Signaling siRNA Therapeutic targets TLR4 protein Toll-Like Receptor 4 - genetics Toll-like receptors Tumor cell lines Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!