The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death

The spliceosome assembles on pre-mRNA in a stepwise manner through five successive pre-spliceosome complexes. The spliceosome functions to remove introns from pre-mRNAs to generate mature mRNAs that encode functional proteins. Many small molecule inhibitors of the spliceosome have been identified an...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0224953
Hauptverfasser:	Vanzyl, Erin J, Sayed, Hadil, Blackmore, Alex B, Rick, Kayleigh R C, Fernando, Pasan, McKay, Bruce C
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 3 Activating Transcription Factor 3 - genetics Activating Transcription Factor 3 - metabolism Animals Antibiotics Apoptosis Apoptosis - drug effects Apoptosis - physiology Biflavonoids - pharmacology Bioflavonoids Biology Biology and Life Sciences Cell death Cell Death - drug effects Cell Death - physiology Cytotoxicity Drugs Embryo fibroblasts Epoxy Compounds - pharmacology Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Flavones Flavonoids Gene expression Gene Expression - drug effects Gene Knockdown Techniques Genetic aspects Genetic research Health aspects HeLa Cells Humans Immunoglobulin G Inhibitors Introns Macrolides - pharmacology Membranes Mice Null cells Penicillin Proteins Research and analysis methods RNA splicing RNA, Small Interfering Sensitivity Spliceosomes Spliceosomes - metabolism Structure Toxicity Transcription factors Tumor cell lines Tumors
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