The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study
The objective of this study was to elucidate the burden, risk factors, and prognosis of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China. The evaluation of the burden, risk factors and prognosis of serious NADEs was carried out among 1309 cART-naive AIDS patients (me...
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| Veröffentlicht in: | PloS one 2020-12, Vol.15 (12), p.e0243773 |
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| creator | Wang, Yu Liang, Hongyuan Zhang, Ling Zhang, Zhe Wu, Liang Ni, Liang Gao, Guiju Yang, Di Zhao, Hongxin Xiao, Jiang |
| description | The objective of this study was to elucidate the burden, risk factors, and prognosis of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China. The evaluation of the burden, risk factors and prognosis of serious NADEs was carried out among 1309 cART-naive AIDS patients (median age: 38.2 years, range: 18-78 years) admitted in Beijing Ditan Hospital between January 2009 and December 2018. Among 1309 patients, 143 patients (10.9%) had at least one serious NADEs, including 49 (3.8%) with cerebrovascular diseases, 37 (2.8%) with non-AIDS-defining cancers, 28 (2.1%) with chronic kidney diseases, 26 (2.0%) with cardiovascular diseases, and 18 (1.4%) with liver cirrhosis. Serious NADEs distributed in different age and CD4 levels, especially with age ≥50 years and CD4 ≤350 cells/ul. Other traditional risk factors, including cigarette smoking (OR = 1.9, 95%CI = 1.3-2.8, p = 0.002), hypertension (OR = 2.5, 95%CI = 1.7-3.7, p |
| doi_str_mv | 10.1371/journal.pone.0243773 |
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The evaluation of the burden, risk factors and prognosis of serious NADEs was carried out among 1309 cART-naive AIDS patients (median age: 38.2 years, range: 18-78 years) admitted in Beijing Ditan Hospital between January 2009 and December 2018. Among 1309 patients, 143 patients (10.9%) had at least one serious NADEs, including 49 (3.8%) with cerebrovascular diseases, 37 (2.8%) with non-AIDS-defining cancers, 28 (2.1%) with chronic kidney diseases, 26 (2.0%) with cardiovascular diseases, and 18 (1.4%) with liver cirrhosis. Serious NADEs distributed in different age and CD4 levels, especially with age ≥50 years and CD4 ≤350 cells/ul. Other traditional risk factors, including cigarette smoking (OR = 1.9, 95%CI = 1.3-2.8, p = 0.002), hypertension (OR = 2.5, 95%CI = 1.7-3.7, p<0.001), chronic HCV infection (OR = 2.8, 95%CI = 1.4-5.6, p = 0.004), and hypercholesterolemia (OR = 4.1, 95% CI = 1.2-14.1, p = 0.026), were also associated with serious NADEs. Seventeen cases (1.3%) with serious NADEs died among hospitalized cART-naive AIDS patients, and severe pneumonia (HR = 5.5, 95%CI = 1.9-15.9, p<0.001) and AIDS-defining cancers (HR = 3.8, 95%CI = 1.1-13.2, p = 0.038) were identified as risk factors associated with an increased hazard of mortality among these patients with serious NADEs. Serious NADEs also occurred in cART-naive AIDS patients in China with low prevalence. Our results reminded physicians that early screening of serious NADEs, timely intervention of their risk factors, management of severe AIDS-defining events, multi-disciplinary cooperation, and early initiation of cART were essential to reduce the burden of serious NADEs.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0243773</identifier><identifier>PMID: 33351812</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - diagnosis ; Acquired Immunodeficiency Syndrome - drug therapy ; Acquired Immunodeficiency Syndrome - epidemiology ; Acquired Immunodeficiency Syndrome - immunology ; Age ; Age Distribution ; Aged ; AIDS ; Anti-HIV Agents - therapeutic use ; Antiviral agents ; Cancer ; Cardiovascular diseases ; CD4 antigen ; CD4 Lymphocyte Count ; Cerebrovascular diseases ; China - epidemiology ; Chronic infection ; Cigarette smoking ; Cirrhosis ; Cohort analysis ; Cohort Studies ; Cost of Illness ; Drug Interactions ; Drug therapy ; Drug therapy, Combination ; Female ; Health hazards ; HIV ; HIV infection ; Human immunodeficiency virus ; Humans ; Hypercholesterolemia ; Hypertension ; Kidney diseases ; Liver cirrhosis ; Male ; Medical imaging ; Medical prognosis ; Medicine and Health Sciences ; Methods ; Middle Aged ; Mortality ; Observational studies ; Patient outcomes ; Physicians ; Prognosis ; Risk analysis ; Risk factors ; Risk management ; Vascular diseases</subject><ispartof>PloS one, 2020-12, Vol.15 (12), p.e0243773</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Wang et al 2020 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e94a586341d9e72e43cc3234a257978468ab4ffc8b249106af79a329db990e6a3</citedby><cites>FETCH-LOGICAL-c692t-e94a586341d9e72e43cc3234a257978468ab4ffc8b249106af79a329db990e6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755215/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755215/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33351812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Liang, Hongyuan</creatorcontrib><creatorcontrib>Zhang, Ling</creatorcontrib><creatorcontrib>Zhang, Zhe</creatorcontrib><creatorcontrib>Wu, Liang</creatorcontrib><creatorcontrib>Ni, Liang</creatorcontrib><creatorcontrib>Gao, Guiju</creatorcontrib><creatorcontrib>Yang, Di</creatorcontrib><creatorcontrib>Zhao, Hongxin</creatorcontrib><creatorcontrib>Xiao, Jiang</creatorcontrib><title>The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The objective of this study was to elucidate the burden, risk factors, and prognosis of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China. The evaluation of the burden, risk factors and prognosis of serious NADEs was carried out among 1309 cART-naive AIDS patients (median age: 38.2 years, range: 18-78 years) admitted in Beijing Ditan Hospital between January 2009 and December 2018. Among 1309 patients, 143 patients (10.9%) had at least one serious NADEs, including 49 (3.8%) with cerebrovascular diseases, 37 (2.8%) with non-AIDS-defining cancers, 28 (2.1%) with chronic kidney diseases, 26 (2.0%) with cardiovascular diseases, and 18 (1.4%) with liver cirrhosis. Serious NADEs distributed in different age and CD4 levels, especially with age ≥50 years and CD4 ≤350 cells/ul. Other traditional risk factors, including cigarette smoking (OR = 1.9, 95%CI = 1.3-2.8, p = 0.002), hypertension (OR = 2.5, 95%CI = 1.7-3.7, p<0.001), chronic HCV infection (OR = 2.8, 95%CI = 1.4-5.6, p = 0.004), and hypercholesterolemia (OR = 4.1, 95% CI = 1.2-14.1, p = 0.026), were also associated with serious NADEs. Seventeen cases (1.3%) with serious NADEs died among hospitalized cART-naive AIDS patients, and severe pneumonia (HR = 5.5, 95%CI = 1.9-15.9, p<0.001) and AIDS-defining cancers (HR = 3.8, 95%CI = 1.1-13.2, p = 0.038) were identified as risk factors associated with an increased hazard of mortality among these patients with serious NADEs. Serious NADEs also occurred in cART-naive AIDS patients in China with low prevalence. Our results reminded physicians that early screening of serious NADEs, timely intervention of their risk factors, management of severe AIDS-defining events, multi-disciplinary cooperation, and early initiation of cART were essential to reduce the burden of serious NADEs.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - diagnosis</subject><subject>Acquired Immunodeficiency Syndrome - drug therapy</subject><subject>Acquired Immunodeficiency Syndrome - epidemiology</subject><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Age</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>AIDS</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiviral agents</subject><subject>Cancer</subject><subject>Cardiovascular diseases</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>Cerebrovascular diseases</subject><subject>China - epidemiology</subject><subject>Chronic infection</subject><subject>Cigarette smoking</subject><subject>Cirrhosis</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Cost of Illness</subject><subject>Drug Interactions</subject><subject>Drug therapy</subject><subject>Drug therapy, Combination</subject><subject>Female</subject><subject>Health hazards</subject><subject>HIV</subject><subject>HIV infection</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hypercholesterolemia</subject><subject>Hypertension</subject><subject>Kidney diseases</subject><subject>Liver cirrhosis</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Observational studies</subject><subject>Patient outcomes</subject><subject>Physicians</subject><subject>Prognosis</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Risk management</subject><subject>Vascular 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burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study</title><author>Wang, Yu ; Liang, Hongyuan ; Zhang, Ling ; Zhang, Zhe ; Wu, Liang ; Ni, Liang ; Gao, Guiju ; Yang, Di ; Zhao, Hongxin ; Xiao, Jiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-e94a586341d9e72e43cc3234a257978468ab4ffc8b249106af79a329db990e6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - diagnosis</topic><topic>Acquired Immunodeficiency Syndrome - drug therapy</topic><topic>Acquired Immunodeficiency Syndrome - epidemiology</topic><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>Age</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>AIDS</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antiviral 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One</addtitle><date>2020-12-22</date><risdate>2020</risdate><volume>15</volume><issue>12</issue><spage>e0243773</spage><pages>e0243773-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The objective of this study was to elucidate the burden, risk factors, and prognosis of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China. The evaluation of the burden, risk factors and prognosis of serious NADEs was carried out among 1309 cART-naive AIDS patients (median age: 38.2 years, range: 18-78 years) admitted in Beijing Ditan Hospital between January 2009 and December 2018. Among 1309 patients, 143 patients (10.9%) had at least one serious NADEs, including 49 (3.8%) with cerebrovascular diseases, 37 (2.8%) with non-AIDS-defining cancers, 28 (2.1%) with chronic kidney diseases, 26 (2.0%) with cardiovascular diseases, and 18 (1.4%) with liver cirrhosis. Serious NADEs distributed in different age and CD4 levels, especially with age ≥50 years and CD4 ≤350 cells/ul. Other traditional risk factors, including cigarette smoking (OR = 1.9, 95%CI = 1.3-2.8, p = 0.002), hypertension (OR = 2.5, 95%CI = 1.7-3.7, p<0.001), chronic HCV infection (OR = 2.8, 95%CI = 1.4-5.6, p = 0.004), and hypercholesterolemia (OR = 4.1, 95% CI = 1.2-14.1, p = 0.026), were also associated with serious NADEs. Seventeen cases (1.3%) with serious NADEs died among hospitalized cART-naive AIDS patients, and severe pneumonia (HR = 5.5, 95%CI = 1.9-15.9, p<0.001) and AIDS-defining cancers (HR = 3.8, 95%CI = 1.1-13.2, p = 0.038) were identified as risk factors associated with an increased hazard of mortality among these patients with serious NADEs. Serious NADEs also occurred in cART-naive AIDS patients in China with low prevalence. Our results reminded physicians that early screening of serious NADEs, timely intervention of their risk factors, management of severe AIDS-defining events, multi-disciplinary cooperation, and early initiation of cART were essential to reduce the burden of serious NADEs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33351812</pmid><doi>10.1371/journal.pone.0243773</doi><tpages>e0243773</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2472087251 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - diagnosis Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - epidemiology Acquired Immunodeficiency Syndrome - immunology Age Age Distribution Aged AIDS Anti-HIV Agents - therapeutic use Antiviral agents Cancer Cardiovascular diseases CD4 antigen CD4 Lymphocyte Count Cerebrovascular diseases China - epidemiology Chronic infection Cigarette smoking Cirrhosis Cohort analysis Cohort Studies Cost of Illness Drug Interactions Drug therapy Drug therapy, Combination Female Health hazards HIV HIV infection Human immunodeficiency virus Humans Hypercholesterolemia Hypertension Kidney diseases Liver cirrhosis Male Medical imaging Medical prognosis Medicine and Health Sciences Methods Middle Aged Mortality Observational studies Patient outcomes Physicians Prognosis Risk analysis Risk factors Risk management Vascular diseases |
| title | The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T21%3A17%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20burden%20of%20serious%20non-AIDS-defining%20events%20among%20admitted%20cART-naive%20AIDS%20patients%20in%20China:%20An%20observational%20cohort%20study&rft.jtitle=PloS%20one&rft.au=Wang,%20Yu&rft.date=2020-12-22&rft.volume=15&rft.issue=12&rft.spage=e0243773&rft.pages=e0243773-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0243773&rft_dat=%3Cgale_plos_%3EA646267509%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2472087251&rft_id=info:pmid/33351812&rft_galeid=A646267509&rft_doaj_id=oai_doaj_org_article_f300165d03bb4819813bb94174f3e3e3&rfr_iscdi=true |