Acquisition and decay of IgM and IgG responses to merozoite antigens after Plasmodium falciparum malaria in Ghanaian children

Developing a vaccine against Plasmodium falciparum malaria has been challenging, primarily due to high levels of antigen polymorphism and a complex parasite lifecycle. Immunization with the P. falciparum merozoite antigens PfMSRP5, PfSERA9, PfRAMA, PfCyRPA and PfRH5 has been shown to give rise to gr...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0243943-e0243943
Hauptverfasser:	Walker, Melanie R, Knudsen, Anne S, Partey, Frederica D, Bassi, Maria R, Frank, Asger M, Castberg, Filip C, Sarbah, Edem W, Ofori, Michael F, Hviid, Lars, Barfod, Lea
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults Aged Antibodies Antibodies, Protozoan - immunology Antigens Antigens, Protozoan - immunology Antisera Biology and Life Sciences Child Child, Preschool Children Development and progression Erythrocytes Ethics Female Health aspects Hospitals Humans Immune response Immunization Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin M Immunoglobulin M - immunology Immunology Infant Infections Life cycle analysis Malaria Malaria vaccine Malaria Vaccines - immunology Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Male Medical research Medicine and Health Sciences Merozoites - immunology Merozoites - pathogenicity Microscopy Middle Aged Parasite antigens Parasitemia Parasites Parasitology Pediatric research Plasmids Plasmodium falciparum Plasmodium falciparum - immunology Plasmodium falciparum - pathogenicity Polymorphism Prevention Research and Analysis Methods Vaccines Vector-borne diseases Viruses West Nile virus Young Adult
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