The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans

Insulin and insulin-like growth factors are longevity determinants that negatively regulate Forkhead box class O (FoxO) transcription factors. In C. elegans mutations that constitutively activate DAF-16, the ortholog of mammalian FoxO3a, extend lifespan by two-fold. While environmental insults induc...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0229812-e0229812
Hauptverfasser:	Rivard, Rebecca S, Morris, Julia M, Youngman, Matthew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Age Aging Aging - metabolism Animals Bacterial infections Biology Biology and life sciences Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - metabolism Caenorhabditis elegans Proteins - physiology Cell cycle Cell division Constituents Environmental stress Enzymes Forkhead protein Forkhead Transcription Factors - metabolism Forkhead Transcription Factors - physiology FOXO3 protein Gene expression Genetic aspects Genetics Growth factors Infections Innate immunity Insulin Insulin-like growth factors Kinases Life span Ligands Longevity - genetics Medicine and Health Sciences Mutation People and Places Phosphatase Phosphatases Phosphoprotein Phosphatases - metabolism Phosphorylation Physical Sciences Physiological aspects Protein Phosphatase 2 - metabolism Protein Phosphatase 2 - physiology Proteins Research and Analysis Methods Scaffolding Signal Transduction Stress (Physiology) Stress, Physiological - physiology Transcription factors Ultraviolet radiation Worms
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