Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection
Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitaliz...
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creator | Jacobs, Laurie G Gourna Paleoudis, Elli Lesky-Di Bari, Dineen Nyirenda, Themba Friedman, Tamara Gupta, Anjali Rasouli, Lily Zetkulic, Marygrace Balani, Bindu Ogedegbe, Chinwe Bawa, Harinder Berrol, Lauren Qureshi, Nabiha Aschner, Judy L |
description | Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function.
This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p |
doi_str_mv | 10.1371/journal.pone.0243882 |
format | Article |
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This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p <0.0001), mental health (43.7%, OR 0.093 [95% CI: 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI: 0.031, 0.291], p<0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI: 2·216, 33·884], p = 0·0019).
COVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. Early post-acute evaluation of symptoms and their impact on function is necessary to plan community-based services.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0243882</identifier><identifier>PMID: 33306721</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cardiovascular disease ; Care and treatment ; Community planning ; Coronaviruses ; COVID-19 ; COVID-19 - psychology ; COVID-19 - therapy ; Dyspnea ; Female ; Health aspects ; Hospitalization ; Hospitals ; Humans ; Illnesses ; Infections ; Internal medicine ; Male ; Medicine ; Medicine and Health Sciences ; Mental Health ; Middle Aged ; New Jersey ; Pain ; Pandemics ; Parameter identification ; Patient outcomes ; Pediatrics ; Physical Sciences ; Prospective Studies ; Quality of Life ; Quarantine ; Respiration ; Respiratory diseases ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Signs and symptoms ; Time Factors ; Ventilators</subject><ispartof>PloS one, 2020-12, Vol.15 (12), p.e0243882-e0243882</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Jacobs et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Jacobs et al 2020 Jacobs et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-376676d0eb3fee5a292ec09eee6438fda28df6b3a26bdcf56882bd967bfaf523</citedby><cites>FETCH-LOGICAL-c692t-376676d0eb3fee5a292ec09eee6438fda28df6b3a26bdcf56882bd967bfaf523</cites><orcidid>0000-0003-3609-2157</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732078/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732078/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33306721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacobs, Laurie G</creatorcontrib><creatorcontrib>Gourna Paleoudis, Elli</creatorcontrib><creatorcontrib>Lesky-Di Bari, Dineen</creatorcontrib><creatorcontrib>Nyirenda, Themba</creatorcontrib><creatorcontrib>Friedman, Tamara</creatorcontrib><creatorcontrib>Gupta, Anjali</creatorcontrib><creatorcontrib>Rasouli, Lily</creatorcontrib><creatorcontrib>Zetkulic, Marygrace</creatorcontrib><creatorcontrib>Balani, Bindu</creatorcontrib><creatorcontrib>Ogedegbe, Chinwe</creatorcontrib><creatorcontrib>Bawa, Harinder</creatorcontrib><creatorcontrib>Berrol, Lauren</creatorcontrib><creatorcontrib>Qureshi, Nabiha</creatorcontrib><creatorcontrib>Aschner, Judy L</creatorcontrib><title>Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function.
This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p <0.0001), mental health (43.7%, OR 0.093 [95% CI: 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI: 0.031, 0.291], p<0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI: 2·216, 33·884], p = 0·0019).
COVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. Early post-acute evaluation of symptoms and their impact on function is necessary to plan community-based services.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Community planning</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - psychology</subject><subject>COVID-19 - therapy</subject><subject>Dyspnea</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Infections</subject><subject>Internal medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mental Health</subject><subject>Middle Aged</subject><subject>New Jersey</subject><subject>Pain</subject><subject>Pandemics</subject><subject>Parameter identification</subject><subject>Patient outcomes</subject><subject>Pediatrics</subject><subject>Physical Sciences</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Quarantine</subject><subject>Respiration</subject><subject>Respiratory diseases</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Signs and symptoms</subject><subject>Time Factors</subject><subject>Ventilators</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7jr6D0QLgujFjPlo0-ZmYRm_BhZGdNnbkKYnMxnaZjZJxfHXmzrdZSp7Ib1IOXnOm5w35yTJS4wWmBb4w872rpPNYm87WCCS0bIkj5JzzCmZM4Lo45P_s-SZ9zuEcloy9jQ5o5QiVhB8nqhv4LzxAToFqdWpP7T7YFufyq5Ob3vZmHAY4o3RkMqQ0jyt5SFu6wAu3Vq_NyFCv2Uwtku1delyfbP6OMc8NZ0GNYSfJ0-0bDy8GNdZcv350_Xy6_xq_WW1vLyaK8ZJmNOCsYLVCCqqAXJJOAGFOACwWJyuJSlrzSoqCatqpXMWC65qzopKS50TOkteH2X3jfVitMcLkjGe47wgPBKrI1FbuRN7Z1rpDsJKI_4GrNsI6YJRDYjojsRccqhLlulS80yRsqIEAKMMSBG1LsbT-qqFWkEXnGwmotOdzmzFxv4URUEJKsoo8G4UcPa2Bx9Ea7yCppEd2H64d4EQzTFhEX3zD_pwdSO1kbGA6L6N56pBVFyyLHI0i0bOksUDVPxqaI2KvaRNjE8S3k8SIhPgV9jI3nux-vH9_9n1zZR9e8JuQTZh623TDx3jp2B2BJWz3jvQ9yZjJIZRuHNDDKMgxlGIaa9OH-g-6a736R-88wOt</recordid><startdate>20201211</startdate><enddate>20201211</enddate><creator>Jacobs, 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of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection</title><author>Jacobs, Laurie G ; Gourna Paleoudis, Elli ; Lesky-Di Bari, Dineen ; Nyirenda, Themba ; Friedman, Tamara ; Gupta, Anjali ; Rasouli, Lily ; Zetkulic, Marygrace ; Balani, Bindu ; Ogedegbe, Chinwe ; Bawa, Harinder ; Berrol, Lauren ; Qureshi, Nabiha ; Aschner, Judy L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-376676d0eb3fee5a292ec09eee6438fda28df6b3a26bdcf56882bd967bfaf523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Community planning</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - psychology</topic><topic>COVID-19 - therapy</topic><topic>Dyspnea</topic><topic>Female</topic><topic>Health 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One</addtitle><date>2020-12-11</date><risdate>2020</risdate><volume>15</volume><issue>12</issue><spage>e0243882</spage><epage>e0243882</epage><pages>e0243882-e0243882</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function.
This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p <0.0001), mental health (43.7%, OR 0.093 [95% CI: 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI: 0.031, 0.291], p<0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI: 2·216, 33·884], p = 0·0019).
COVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. Early post-acute evaluation of symptoms and their impact on function is necessary to plan community-based services.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33306721</pmid><doi>10.1371/journal.pone.0243882</doi><tpages>e0243882</tpages><orcidid>https://orcid.org/0000-0003-3609-2157</orcidid><oa>free_for_read</oa></addata></record> |
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recordid | cdi_plos_journals_2469515729 |
source | PubMed (Medline); PLoS; MEDLINE; DOAJ Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
subjects | Adult Aged Aged, 80 and over Cardiovascular disease Care and treatment Community planning Coronaviruses COVID-19 COVID-19 - psychology COVID-19 - therapy Dyspnea Female Health aspects Hospitalization Hospitals Humans Illnesses Infections Internal medicine Male Medicine Medicine and Health Sciences Mental Health Middle Aged New Jersey Pain Pandemics Parameter identification Patient outcomes Pediatrics Physical Sciences Prospective Studies Quality of Life Quarantine Respiration Respiratory diseases SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Signs and symptoms Time Factors Ventilators |
title | Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T23%3A46%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Persistence%20of%20symptoms%20and%20quality%20of%20life%20at%2035%20days%20after%20hospitalization%20for%20COVID-19%20infection&rft.jtitle=PloS%20one&rft.au=Jacobs,%20Laurie%20G&rft.date=2020-12-11&rft.volume=15&rft.issue=12&rft.spage=e0243882&rft.epage=e0243882&rft.pages=e0243882-e0243882&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0243882&rft_dat=%3Cgale_plos_%3EA644693464%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2469515729&rft_id=info:pmid/33306721&rft_galeid=A644693464&rft_doaj_id=oai_doaj_org_article_672a19a9ed864f8f94c28b32ee104e27&rfr_iscdi=true |