Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection

Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitaliz...

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Veröffentlicht in:PloS one 2020-12, Vol.15 (12), p.e0243882-e0243882
Hauptverfasser: Jacobs, Laurie G, Gourna Paleoudis, Elli, Lesky-Di Bari, Dineen, Nyirenda, Themba, Friedman, Tamara, Gupta, Anjali, Rasouli, Lily, Zetkulic, Marygrace, Balani, Bindu, Ogedegbe, Chinwe, Bawa, Harinder, Berrol, Lauren, Qureshi, Nabiha, Aschner, Judy L
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container_issue 12
container_start_page e0243882
container_title PloS one
container_volume 15
creator Jacobs, Laurie G
Gourna Paleoudis, Elli
Lesky-Di Bari, Dineen
Nyirenda, Themba
Friedman, Tamara
Gupta, Anjali
Rasouli, Lily
Zetkulic, Marygrace
Balani, Bindu
Ogedegbe, Chinwe
Bawa, Harinder
Berrol, Lauren
Qureshi, Nabiha
Aschner, Judy L
description Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function. This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p
doi_str_mv 10.1371/journal.pone.0243882
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The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p &lt;0.0001), mental health (43.7%, OR 0.093 [95% CI: 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI: 0.031, 0.291], p&lt;0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI: 2·216, 33·884], p = 0·0019). COVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. 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The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p &lt;0.0001), mental health (43.7%, OR 0.093 [95% CI: 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI: 0.031, 0.291], p&lt;0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI: 2·216, 33·884], p = 0·0019). COVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. 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Gourna Paleoudis, Elli ; Lesky-Di Bari, Dineen ; Nyirenda, Themba ; Friedman, Tamara ; Gupta, Anjali ; Rasouli, Lily ; Zetkulic, Marygrace ; Balani, Bindu ; Ogedegbe, Chinwe ; Bawa, Harinder ; Berrol, Lauren ; Qureshi, Nabiha ; Aschner, Judy L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-376676d0eb3fee5a292ec09eee6438fda28df6b3a26bdcf56882bd967bfaf523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Community planning</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - psychology</topic><topic>COVID-19 - therapy</topic><topic>Dyspnea</topic><topic>Female</topic><topic>Health aspects</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Infections</topic><topic>Internal medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Mental Health</topic><topic>Middle Aged</topic><topic>New Jersey</topic><topic>Pain</topic><topic>Pandemics</topic><topic>Parameter identification</topic><topic>Patient outcomes</topic><topic>Pediatrics</topic><topic>Physical Sciences</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Quarantine</topic><topic>Respiration</topic><topic>Respiratory diseases</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Signs and symptoms</topic><topic>Time Factors</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacobs, Laurie G</creatorcontrib><creatorcontrib>Gourna Paleoudis, Elli</creatorcontrib><creatorcontrib>Lesky-Di Bari, Dineen</creatorcontrib><creatorcontrib>Nyirenda, Themba</creatorcontrib><creatorcontrib>Friedman, Tamara</creatorcontrib><creatorcontrib>Gupta, Anjali</creatorcontrib><creatorcontrib>Rasouli, Lily</creatorcontrib><creatorcontrib>Zetkulic, Marygrace</creatorcontrib><creatorcontrib>Balani, Bindu</creatorcontrib><creatorcontrib>Ogedegbe, Chinwe</creatorcontrib><creatorcontrib>Bawa, Harinder</creatorcontrib><creatorcontrib>Berrol, Lauren</creatorcontrib><creatorcontrib>Qureshi, Nabiha</creatorcontrib><creatorcontrib>Aschner, Judy L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints In Context</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; 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This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function. This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p &lt;0.0001), mental health (43.7%, OR 0.093 [95% CI: 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI: 0.031, 0.291], p&lt;0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI: 2·216, 33·884], p = 0·0019). COVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. Early post-acute evaluation of symptoms and their impact on function is necessary to plan community-based services.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33306721</pmid><doi>10.1371/journal.pone.0243882</doi><tpages>e0243882</tpages><orcidid>https://orcid.org/0000-0003-3609-2157</orcidid><oa>free_for_read</oa></addata></record>
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source PubMed (Medline); PLoS; MEDLINE; DOAJ Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library
subjects Adult
Aged
Aged, 80 and over
Cardiovascular disease
Care and treatment
Community planning
Coronaviruses
COVID-19
COVID-19 - psychology
COVID-19 - therapy
Dyspnea
Female
Health aspects
Hospitalization
Hospitals
Humans
Illnesses
Infections
Internal medicine
Male
Medicine
Medicine and Health Sciences
Mental Health
Middle Aged
New Jersey
Pain
Pandemics
Parameter identification
Patient outcomes
Pediatrics
Physical Sciences
Prospective Studies
Quality of Life
Quarantine
Respiration
Respiratory diseases
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Time Factors
Ventilators
title Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection
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