Factors mediating the pressor response to isometric muscle contraction: An experimental study in healthy volunteers during lower body negative pressure
Whilst both cardiac output (CO) and total peripheral resistance (TPR) determine mean arterial blood pressure (MAP), their relative importance in the pressor response to isometric exercise remains unclear. This study aimed to elucidate the relative importance of these two different factors by examini...
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| description | Whilst both cardiac output (CO) and total peripheral resistance (TPR) determine mean arterial blood pressure (MAP), their relative importance in the pressor response to isometric exercise remains unclear. This study aimed to elucidate the relative importance of these two different factors by examining pressor responses during cardiopulmonary unloading leading to step-wise reductions in CO. Hemodynamics were investigated in 11 healthy individuals before, during and after two-minute isometric exercise during lower body negative pressure (LBNP; -20mmHg and -40mmHg). The blood pressure response to isometric exercise was similar during normal and reduced preload, despite a step-wise reduction in CO during LBNP (-20mmHg and -40mmHg). During -20mmHg LBNP, the decreased stroke volume, and consequently CO, was counteracted by an increased TPR, while heart rate (HR) was unaffected. HR was increased during -40 mmHg LBNP, although insufficient to maintain CO; the drop in CO was perfectly compensated by an increased TPR to maintain MAP. Likewise, transient application of LBNP (-20mmHg and -40mmHg) resulted in a short transient drop in MAP, caused by a decrease in CO, which was compensated by an increase in TPR. This study suggests that, in case of reductions of CO, changes in TPR are primarily responsible for maintaining the pressor response during isometric exercise. This highlights the relative importance of TPR compared to CO in mediating the pressor response during isometric exercise. |
| doi_str_mv | 10.1371/journal.pone.0243627 |
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This study aimed to elucidate the relative importance of these two different factors by examining pressor responses during cardiopulmonary unloading leading to step-wise reductions in CO. Hemodynamics were investigated in 11 healthy individuals before, during and after two-minute isometric exercise during lower body negative pressure (LBNP; -20mmHg and -40mmHg). The blood pressure response to isometric exercise was similar during normal and reduced preload, despite a step-wise reduction in CO during LBNP (-20mmHg and -40mmHg). During -20mmHg LBNP, the decreased stroke volume, and consequently CO, was counteracted by an increased TPR, while heart rate (HR) was unaffected. HR was increased during -40 mmHg LBNP, although insufficient to maintain CO; the drop in CO was perfectly compensated by an increased TPR to maintain MAP. Likewise, transient application of LBNP (-20mmHg and -40mmHg) resulted in a short transient drop in MAP, caused by a decrease in CO, which was compensated by an increase in TPR. This study suggests that, in case of reductions of CO, changes in TPR are primarily responsible for maintaining the pressor response during isometric exercise. 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This highlights the relative importance of TPR compared to CO in mediating the pressor response during isometric exercise.</description><subject>Adult</subject><subject>Aerospace medicine</subject><subject>Analysis</subject><subject>Anesthesiology</subject><subject>Biology and Life Sciences</subject><subject>Blood Pressure</subject><subject>Blood pressure regulation</subject><subject>Carbon monoxide</subject><subject>Cardiac Output</subject><subject>Exercise</subject><subject>Experiments</subject><subject>Female</subject><subject>Flow velocity</subject><subject>Force</subject><subject>Hand Strength - physiology</subject><subject>Health sciences</subject><subject>Healthy Volunteers</subject><subject>Heart Rate</subject><subject>Hemodynamics</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Isometric Contraction</subject><subject>Isometric exercise</subject><subject>Lower Body Negative Pressure</subject><subject>Male</subject><subject>Medical 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stens, Niels A</au><au>Hisdal, Jonny</au><au>Bakke, Espen F</au><au>Kaur, Narinder</au><au>Sharma, Archana</au><au>Stranden, Einar</au><au>Thijssen, Dick H J</au><au>Høiseth, Lars Øivind</au><au>Cipriano, Gerson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors mediating the pressor response to isometric muscle contraction: An experimental study in healthy volunteers during lower body negative pressure</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-12-09</date><risdate>2020</risdate><volume>15</volume><issue>12</issue><spage>e0243627</spage><epage>e0243627</epage><pages>e0243627-e0243627</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Whilst both cardiac output (CO) and total peripheral resistance (TPR) determine mean arterial blood pressure (MAP), their relative importance in the pressor response to isometric exercise remains unclear. This study aimed to elucidate the relative importance of these two different factors by examining pressor responses during cardiopulmonary unloading leading to step-wise reductions in CO. Hemodynamics were investigated in 11 healthy individuals before, during and after two-minute isometric exercise during lower body negative pressure (LBNP; -20mmHg and -40mmHg). The blood pressure response to isometric exercise was similar during normal and reduced preload, despite a step-wise reduction in CO during LBNP (-20mmHg and -40mmHg). During -20mmHg LBNP, the decreased stroke volume, and consequently CO, was counteracted by an increased TPR, while heart rate (HR) was unaffected. HR was increased during -40 mmHg LBNP, although insufficient to maintain CO; the drop in CO was perfectly compensated by an increased TPR to maintain MAP. Likewise, transient application of LBNP (-20mmHg and -40mmHg) resulted in a short transient drop in MAP, caused by a decrease in CO, which was compensated by an increase in TPR. This study suggests that, in case of reductions of CO, changes in TPR are primarily responsible for maintaining the pressor response during isometric exercise. This highlights the relative importance of TPR compared to CO in mediating the pressor response during isometric exercise.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33296410</pmid><doi>10.1371/journal.pone.0243627</doi><tpages>e0243627</tpages><orcidid>https://orcid.org/0000-0003-0669-8297</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aerospace medicine Analysis Anesthesiology Biology and Life Sciences Blood Pressure Blood pressure regulation Carbon monoxide Cardiac Output Exercise Experiments Female Flow velocity Force Hand Strength - physiology Health sciences Healthy Volunteers Heart Rate Hemodynamics Hospitals Humans Isometric Contraction Isometric exercise Lower Body Negative Pressure Male Medical research Medicine and Health Sciences Muscle contraction Muscles Muscular function Physical training Physiological aspects Physiology Stroke Stroke Volume Ultrasonic imaging Unloading Vascular Resistance Vascular surgery Young Adult |
| title | Factors mediating the pressor response to isometric muscle contraction: An experimental study in healthy volunteers during lower body negative pressure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T10%3A54%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Factors%20mediating%20the%20pressor%20response%20to%20isometric%20muscle%20contraction:%20An%20experimental%20study%20in%20healthy%20volunteers%20during%20lower%20body%20negative%20pressure&rft.jtitle=PloS%20one&rft.au=Stens,%20Niels%20A&rft.date=2020-12-09&rft.volume=15&rft.issue=12&rft.spage=e0243627&rft.epage=e0243627&rft.pages=e0243627-e0243627&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0243627&rft_dat=%3Cgale_plos_%3EA644395079%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2468643224&rft_id=info:pmid/33296410&rft_galeid=A644395079&rft_doaj_id=oai_doaj_org_article_c7227aee58174f3da816f5f2d194733d&rfr_iscdi=true |