Interferon-gamma promotes iron export in human macrophages to limit intracellular bacterial replication

Salmonellosis and listeriosis together accounted for more than one third of foodborne illnesses in the United States and almost half the hospitalizations for gastrointestinal diseases in 2018 while tuberculosis afflicted over 10 million people worldwide causing almost 2 million deaths. Regardless of...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0240949
Hauptverfasser:	Abreu, Rodrigo, Essler, Lauren, Giri, Pramod, Quinn, Frederick
Format:	Artikel
Sprache:	eng
Schlagworte:	Availability Bacilli Bacteria Bacterial diseases Bacterial infections Biological transport Biological Transport, Active - drug effects Biology and Life Sciences Cation Transport Proteins - metabolism Cytokines Drug therapy Exports Ferritin Ferritins - metabolism Foodborne diseases Gastrointestinal diseases Genes Genetic engineering Health aspects Hepcidin Hepcidins - antagonists & inhibitors Hepcidins - metabolism Host Microbial Interactions - drug effects Host Microbial Interactions - immunology Host Microbial Interactions - physiology Humans Immunity, Innate Infections Infectious diseases Interferon Interferon gamma Interferon-gamma - immunology Interferon-gamma - pharmacology Intracellular Iron Iron (Nutrient) Iron - metabolism Listeria Listeria monocytogenes Listeria monocytogenes - growth & development Listeria monocytogenes - pathogenicity Listeriosis Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - microbiology Medicine and Health Sciences Mycobacterium tuberculosis Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - pathogenicity Pathogens Proteins Recombinant Proteins - pharmacology Replication Salmonella Salmonella enterica Salmonella enterica - growth & development Salmonella enterica - pathogenicity Salmonellosis THP-1 Cells Tuberculosis Virulence γ-Interferon
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