The side effect profile of Clozapine in real world data of three large mental health hospitals

Mining the data contained within Electronic Health Records (EHRs) can potentially generate a greater understanding of medication effects in the real world, complementing what we know from Randomised control trials (RCTs). We Propose a text mining approach to detect adverse events and medication epis...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0243437
Hauptverfasser:	Iqbal, Ehtesham, Govind, Risha, Romero, Alvin, Dzahini, Olubanke, Broadbent, Matthew, Stewart, Robert, Smith, Tanya, Kim, Chi-Hun, Werbeloff, Nomi, MacCabe, James H, Dobson, Richard J B, Ibrahim, Zina M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adverse drug reactions Antipsychotic Agents - adverse effects Antipsychotics Benzodiazepines - administration & dosage Benzodiazepines - adverse effects Biomedical research Cardiomyopathy Clinical trials Clozapine Clozapine - administration & dosage Clozapine - adverse effects Complications and side effects Constipation Data mining Databases, Factual Dementia Diabetes Drug stores Drug therapy Electronic health records Electronic medical records Ethnicity Female Gender Health informatics Health services Hospitals Hospitals, Psychiatric Humans Hypertension Infant Male Medicine and Health Sciences Mental disorders Mental health Middle Aged Minority & ethnic groups Neurosciences Olanzapine - administration & dosage Olanzapine - adverse effects Patient admissions Patients People and Places Piperazines - administration & dosage Piperazines - adverse effects Psychiatry Psychotropic drugs Research and Analysis Methods Risk factors Risperidone - administration & dosage Risperidone - adverse effects Schizophrenia Schizophrenia - complications Schizophrenia - drug therapy Schizophrenia - physiopathology Side effects Smoking Statistics Tachycardia Thiazoles - administration & dosage Thiazoles - adverse effects Weight Gain - drug effects
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