Assessment of antimalarial drug resistant markers in asymptomatic Plasmodium falciparum infections after 4 years of indoor residual spraying in Northern Ghana

Drug resistance remains a concern for malaria control and elimination. The effect of interventions on its prevalence needs to be monitored to pre-empt further selection. We assessed the prevalence of Plasmodium falciparum gene mutations associated with resistance to the antimalarial drugs: sulfadoxi...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0233478-e0233478
Hauptverfasser:	Myers-Hansen, James L, Abuaku, Benjamin, Oyebola, Muyiwa K, Mensah, Benedicta A, Ahorlu, Collins, Wilson, Michael D, Awandare, Gordon, Koram, Kwadwo A, Ngwa, Alfred Amambua, Ghansah, Anita
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amodiaquine Amodiaquine - pharmacology Anemia Antimalarial agents Antimalarials - pharmacology Antimalarials - therapeutic use Antimicrobial agents Artemisinin Asymptomatic Biology and Life Sciences Biomarkers, Pharmacological - analysis Carrier State - epidemiology Child, Preschool Chloroquine Chloroquine - pharmacology Chromosomes Control Dihydrofolate reductase Disease transmission DNA, Protozoan - genetics Drug Combinations Drug resistance Drug Resistance - genetics Female Gene mutation Genes Genetic aspects Genetic markers Genotype Ghana - epidemiology Haplotypes Humans Infant Infections Insecticides Intervention Malaria Malaria - drug therapy Malaria, Falciparum - epidemiology Male Medical research Medicine and Health Sciences Mefloquine Microbial drug resistance Microscopy Mutants Mutation Nucleotides Parasites Pathogens People and Places Physiological aspects Plasmodium falciparum Plasmodium falciparum - genetics Polymerase Chain Reaction Protozoan Proteins - genetics Pyrimethamine Pyrimethamine - pharmacology Seasons Single-nucleotide polymorphism Spraying Sulfadoxine Sulfadoxine - pharmacology Trends Vector-borne diseases
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