TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients

Tuberculosis screening in psoriasis patients is complex due to the immunological alterations associated with psoriasis, the presence of comorbidities, and the effect of immunosuppressive treatment. However, it is not established whether the results of screening tests are affected by these factors in...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0242098
Hauptverfasser:	de Medeiros, Vanessa Lucília Silveira, Santos, Fabiana Cristina Fulco, Montenegro, Lílian Maria Lapa, Silva, Maria da Conceição, Souza, Valdênia Maria Oliveira de, Lima Neto, Reginaldo Gonçalvez de, Moura, Líbia Cristina Rocha Vilela, Magalhães, Vera
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Anemia Biology and Life Sciences Body mass Body mass index Body size C-reactive protein C-Reactive Protein - metabolism Clinics Comorbidity Demographic aspects Dermatology Diabetes Diagnosis Diagnostic systems Dihydrofolate reductase Drug therapy Enzymes Erythrocyte sedimentation rate Erythrocytes Ethics Female Health aspects Health services Hepatitis Humans Immunization Immunology Immunosuppressive Agents - administration & dosage Inflammation Interferon Interferon gamma Interferon-gamma - blood Laboratories Latent Tuberculosis - complications Latent Tuberculosis - drug therapy Latent Tuberculosis - epidemiology Latent Tuberculosis - microbiology Male Mass Screening Medicine Medicine and Health Sciences Methotrexate Methotrexate - administration & dosage Methotrexate - adverse effects Middle Aged Patient outcomes Patients Psoriasis Psoriasis - blood Psoriasis - complications Psoriasis - drug therapy Psoriasis - epidemiology Risk factors Serology Severity of Illness Index Skin tests Substance abuse treatment Tuberculin Tuberculin test Tuberculin Test - adverse effects Tuberculosis Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF Tumor necrosis factor-α Womens health Young Adult γ-Interferon
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