Intraretinal microvascular changes after ERM and ILM peeling using SSOCTA
To prospectively investigate retinal vascular changes in patients undergoing epiretinal membrane (ERM) and internal limiting membrane (ILM) peeling using swept source optical coherence tomography angiography (SSOCTA). Consecutive patients were grouped based on ERM severity and followed using SSOCTA...
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| creator | Told, Reinhard Georgopoulos, Michael Reiter, Gregor Sebastian Wassermann, Lorenz Aliyeva, Leyla Baumann, Lukas Abela-Formanek, Claudette Pollreisz, Andreas Schmidt-Erfurth, Ursula Sacu, Stefan |
| description | To prospectively investigate retinal vascular changes in patients undergoing epiretinal membrane (ERM) and internal limiting membrane (ILM) peeling using swept source optical coherence tomography angiography (SSOCTA).
Consecutive patients were grouped based on ERM severity and followed using SSOCTA up to month 3 after surgical intervention. Superficial and deep foveal avascular zone (s/dFAZ) as well as foveal and parafoveal vessel density (VD) were correlated with ERM severity and visual acuity. Differences between groups were evaluated.
Significant correlations were found between ERM severity and baseline sFAZ, dFAZ and best corrected visual acuity (BCVA), central retinal subfield thickness (CST) and ΔCST (r = -0.52, r = -0.43, r = -0.42, r = 0.58, r = 0.39; all p0.05).
This study clearly shows that ERM severity based on ERM staging has to be taken into account when undertaking studies in patients with idiopathic ERM using SSOCTA. Further, specific changes in the superficial and deep retinal vasculature in eyes undergoing ERM and ILM peeling were found. However, the clinical usefulness and prognostic value for post-surgical treatment BCVA of the SSOCTA-derived variables (sFAZ and dFAZ area, as well as foveal and parafoveal VD) used remains questionable. |
| doi_str_mv | 10.1371/journal.pone.0242667 |
| format | Article |
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Consecutive patients were grouped based on ERM severity and followed using SSOCTA up to month 3 after surgical intervention. Superficial and deep foveal avascular zone (s/dFAZ) as well as foveal and parafoveal vessel density (VD) were correlated with ERM severity and visual acuity. Differences between groups were evaluated.
Significant correlations were found between ERM severity and baseline sFAZ, dFAZ and best corrected visual acuity (BCVA), central retinal subfield thickness (CST) and ΔCST (r = -0.52, r = -0.43, r = -0.42, r = 0.58, r = 0.39; all p<0.05). Vascular flow parameters did not correlate with age, peeling size, pseudophakia or CST, but correlated with intraretinal cysts presence. No associations of BCVA with any of the OCTA parameters across time were found. Significant differences between ERM severity groups 1 and 2 were found for sFAZ at baseline (p = 0.005) and at the 3-month follow-up (p = 0.014), and for dFAZ at baseline (p = 0.017). Superficial foveal and parafoveal VD were not significantly different between groups (all p>0.05).
This study clearly shows that ERM severity based on ERM staging has to be taken into account when undertaking studies in patients with idiopathic ERM using SSOCTA. Further, specific changes in the superficial and deep retinal vasculature in eyes undergoing ERM and ILM peeling were found. However, the clinical usefulness and prognostic value for post-surgical treatment BCVA of the SSOCTA-derived variables (sFAZ and dFAZ area, as well as foveal and parafoveal VD) used remains questionable.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0242667</identifier><identifier>PMID: 33259500</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acuity ; Aged ; Angiography ; Biology and Life Sciences ; Blood vessels ; Blood Vessels - diagnostic imaging ; Blood Vessels - growth & development ; Blood Vessels - physiopathology ; Cataracts ; Computer and Information Sciences ; Correlation ; Cysts ; Demographic aspects ; Development and progression ; Diagnosis ; Disease ; Engineering and Technology ; Epiretinal Membrane - diagnostic imaging ; Epiretinal Membrane - physiopathology ; Eye (anatomy) ; Female ; Fluorescein Angiography ; Fovea Centralis - blood supply ; Fovea Centralis - physiopathology ; Humans ; Macula Lutea - blood supply ; Macula Lutea - diagnostic imaging ; Macula Lutea - physiopathology ; Macular degeneration ; Male ; Medical imaging ; Medicine and Health Sciences ; Membranes ; Microvasculature ; Middle Aged ; Optical tomography ; Optometry ; Parameters ; Patients ; Peeling ; Research and Analysis Methods ; Retina ; Retina - diagnostic imaging ; Retina - physiopathology ; Retinal Vessels - diagnostic imaging ; Retinal Vessels - growth & development ; Retinal Vessels - physiopathology ; Social Sciences ; Tomography, Optical Coherence ; Visual acuity ; Visual Acuity - physiology ; Vitrectomy</subject><ispartof>PloS one, 2020-12, Vol.15 (12), p.e0242667-e0242667</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Told et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Told et al 2020 Told et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b6576c1e20a5e7083b473c253f4fae4e4d4c58b236d34c02ee77a09c601b52c13</citedby><cites>FETCH-LOGICAL-c692t-b6576c1e20a5e7083b473c253f4fae4e4d4c58b236d34c02ee77a09c601b52c13</cites><orcidid>0000-0003-2046-7081 ; 0000-0001-7661-4015 ; 0000-0002-4920-2231</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707569/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707569/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33259500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lewin, Alfred S</contributor><creatorcontrib>Told, Reinhard</creatorcontrib><creatorcontrib>Georgopoulos, Michael</creatorcontrib><creatorcontrib>Reiter, Gregor Sebastian</creatorcontrib><creatorcontrib>Wassermann, Lorenz</creatorcontrib><creatorcontrib>Aliyeva, Leyla</creatorcontrib><creatorcontrib>Baumann, Lukas</creatorcontrib><creatorcontrib>Abela-Formanek, Claudette</creatorcontrib><creatorcontrib>Pollreisz, Andreas</creatorcontrib><creatorcontrib>Schmidt-Erfurth, Ursula</creatorcontrib><creatorcontrib>Sacu, Stefan</creatorcontrib><title>Intraretinal microvascular changes after ERM and ILM peeling using SSOCTA</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To prospectively investigate retinal vascular changes in patients undergoing epiretinal membrane (ERM) and internal limiting membrane (ILM) peeling using swept source optical coherence tomography angiography (SSOCTA).
Consecutive patients were grouped based on ERM severity and followed using SSOCTA up to month 3 after surgical intervention. Superficial and deep foveal avascular zone (s/dFAZ) as well as foveal and parafoveal vessel density (VD) were correlated with ERM severity and visual acuity. Differences between groups were evaluated.
Significant correlations were found between ERM severity and baseline sFAZ, dFAZ and best corrected visual acuity (BCVA), central retinal subfield thickness (CST) and ΔCST (r = -0.52, r = -0.43, r = -0.42, r = 0.58, r = 0.39; all p<0.05). Vascular flow parameters did not correlate with age, peeling size, pseudophakia or CST, but correlated with intraretinal cysts presence. No associations of BCVA with any of the OCTA parameters across time were found. Significant differences between ERM severity groups 1 and 2 were found for sFAZ at baseline (p = 0.005) and at the 3-month follow-up (p = 0.014), and for dFAZ at baseline (p = 0.017). Superficial foveal and parafoveal VD were not significantly different between groups (all p>0.05).
This study clearly shows that ERM severity based on ERM staging has to be taken into account when undertaking studies in patients with idiopathic ERM using SSOCTA. Further, specific changes in the superficial and deep retinal vasculature in eyes undergoing ERM and ILM peeling were found. However, the clinical usefulness and prognostic value for post-surgical treatment BCVA of the SSOCTA-derived variables (sFAZ and dFAZ area, as well as foveal and parafoveal VD) used remains questionable.</description><subject>Acuity</subject><subject>Aged</subject><subject>Angiography</subject><subject>Biology and Life Sciences</subject><subject>Blood vessels</subject><subject>Blood Vessels - diagnostic imaging</subject><subject>Blood Vessels - growth & development</subject><subject>Blood Vessels - physiopathology</subject><subject>Cataracts</subject><subject>Computer and Information Sciences</subject><subject>Correlation</subject><subject>Cysts</subject><subject>Demographic aspects</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Engineering and Technology</subject><subject>Epiretinal Membrane - diagnostic imaging</subject><subject>Epiretinal Membrane - physiopathology</subject><subject>Eye (anatomy)</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Fovea Centralis - blood supply</subject><subject>Fovea Centralis - physiopathology</subject><subject>Humans</subject><subject>Macula Lutea - blood supply</subject><subject>Macula Lutea - diagnostic imaging</subject><subject>Macula Lutea - physiopathology</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Membranes</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>Optical tomography</subject><subject>Optometry</subject><subject>Parameters</subject><subject>Patients</subject><subject>Peeling</subject><subject>Research and Analysis Methods</subject><subject>Retina</subject><subject>Retina - diagnostic imaging</subject><subject>Retina - physiopathology</subject><subject>Retinal Vessels - diagnostic imaging</subject><subject>Retinal Vessels - growth & development</subject><subject>Retinal Vessels - physiopathology</subject><subject>Social Sciences</subject><subject>Tomography, Optical Coherence</subject><subject>Visual acuity</subject><subject>Visual Acuity - 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diagnostic imaging</topic><topic>Blood Vessels - growth & development</topic><topic>Blood Vessels - physiopathology</topic><topic>Cataracts</topic><topic>Computer and Information Sciences</topic><topic>Correlation</topic><topic>Cysts</topic><topic>Demographic aspects</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>Engineering and Technology</topic><topic>Epiretinal Membrane - diagnostic imaging</topic><topic>Epiretinal Membrane - physiopathology</topic><topic>Eye (anatomy)</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Fovea Centralis - blood supply</topic><topic>Fovea Centralis - physiopathology</topic><topic>Humans</topic><topic>Macula Lutea - blood supply</topic><topic>Macula Lutea - diagnostic imaging</topic><topic>Macula Lutea - physiopathology</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Membranes</topic><topic>Microvasculature</topic><topic>Middle Aged</topic><topic>Optical tomography</topic><topic>Optometry</topic><topic>Parameters</topic><topic>Patients</topic><topic>Peeling</topic><topic>Research and Analysis Methods</topic><topic>Retina</topic><topic>Retina - diagnostic imaging</topic><topic>Retina - physiopathology</topic><topic>Retinal Vessels - diagnostic imaging</topic><topic>Retinal Vessels - growth & development</topic><topic>Retinal Vessels - physiopathology</topic><topic>Social Sciences</topic><topic>Tomography, Optical Coherence</topic><topic>Visual acuity</topic><topic>Visual Acuity - physiology</topic><topic>Vitrectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Told, Reinhard</creatorcontrib><creatorcontrib>Georgopoulos, Michael</creatorcontrib><creatorcontrib>Reiter, Gregor Sebastian</creatorcontrib><creatorcontrib>Wassermann, Lorenz</creatorcontrib><creatorcontrib>Aliyeva, Leyla</creatorcontrib><creatorcontrib>Baumann, Lukas</creatorcontrib><creatorcontrib>Abela-Formanek, Claudette</creatorcontrib><creatorcontrib>Pollreisz, Andreas</creatorcontrib><creatorcontrib>Schmidt-Erfurth, Ursula</creatorcontrib><creatorcontrib>Sacu, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Told, Reinhard</au><au>Georgopoulos, Michael</au><au>Reiter, Gregor Sebastian</au><au>Wassermann, Lorenz</au><au>Aliyeva, Leyla</au><au>Baumann, Lukas</au><au>Abela-Formanek, Claudette</au><au>Pollreisz, Andreas</au><au>Schmidt-Erfurth, Ursula</au><au>Sacu, Stefan</au><au>Lewin, Alfred S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraretinal microvascular changes after ERM and ILM peeling using SSOCTA</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>15</volume><issue>12</issue><spage>e0242667</spage><epage>e0242667</epage><pages>e0242667-e0242667</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To prospectively investigate retinal vascular changes in patients undergoing epiretinal membrane (ERM) and internal limiting membrane (ILM) peeling using swept source optical coherence tomography angiography (SSOCTA).
Consecutive patients were grouped based on ERM severity and followed using SSOCTA up to month 3 after surgical intervention. Superficial and deep foveal avascular zone (s/dFAZ) as well as foveal and parafoveal vessel density (VD) were correlated with ERM severity and visual acuity. Differences between groups were evaluated.
Significant correlations were found between ERM severity and baseline sFAZ, dFAZ and best corrected visual acuity (BCVA), central retinal subfield thickness (CST) and ΔCST (r = -0.52, r = -0.43, r = -0.42, r = 0.58, r = 0.39; all p<0.05). Vascular flow parameters did not correlate with age, peeling size, pseudophakia or CST, but correlated with intraretinal cysts presence. No associations of BCVA with any of the OCTA parameters across time were found. Significant differences between ERM severity groups 1 and 2 were found for sFAZ at baseline (p = 0.005) and at the 3-month follow-up (p = 0.014), and for dFAZ at baseline (p = 0.017). Superficial foveal and parafoveal VD were not significantly different between groups (all p>0.05).
This study clearly shows that ERM severity based on ERM staging has to be taken into account when undertaking studies in patients with idiopathic ERM using SSOCTA. Further, specific changes in the superficial and deep retinal vasculature in eyes undergoing ERM and ILM peeling were found. However, the clinical usefulness and prognostic value for post-surgical treatment BCVA of the SSOCTA-derived variables (sFAZ and dFAZ area, as well as foveal and parafoveal VD) used remains questionable.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33259500</pmid><doi>10.1371/journal.pone.0242667</doi><tpages>e0242667</tpages><orcidid>https://orcid.org/0000-0003-2046-7081</orcidid><orcidid>https://orcid.org/0000-0001-7661-4015</orcidid><orcidid>https://orcid.org/0000-0002-4920-2231</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-12, Vol.15 (12), p.e0242667-e0242667 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2466020553 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acuity Aged Angiography Biology and Life Sciences Blood vessels Blood Vessels - diagnostic imaging Blood Vessels - growth & development Blood Vessels - physiopathology Cataracts Computer and Information Sciences Correlation Cysts Demographic aspects Development and progression Diagnosis Disease Engineering and Technology Epiretinal Membrane - diagnostic imaging Epiretinal Membrane - physiopathology Eye (anatomy) Female Fluorescein Angiography Fovea Centralis - blood supply Fovea Centralis - physiopathology Humans Macula Lutea - blood supply Macula Lutea - diagnostic imaging Macula Lutea - physiopathology Macular degeneration Male Medical imaging Medicine and Health Sciences Membranes Microvasculature Middle Aged Optical tomography Optometry Parameters Patients Peeling Research and Analysis Methods Retina Retina - diagnostic imaging Retina - physiopathology Retinal Vessels - diagnostic imaging Retinal Vessels - growth & development Retinal Vessels - physiopathology Social Sciences Tomography, Optical Coherence Visual acuity Visual Acuity - physiology Vitrectomy |
| title | Intraretinal microvascular changes after ERM and ILM peeling using SSOCTA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T10%3A39%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intraretinal%20microvascular%20changes%20after%20ERM%20and%20ILM%20peeling%20using%20SSOCTA&rft.jtitle=PloS%20one&rft.au=Told,%20Reinhard&rft.date=2020-12-01&rft.volume=15&rft.issue=12&rft.spage=e0242667&rft.epage=e0242667&rft.pages=e0242667-e0242667&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0242667&rft_dat=%3Cgale_plos_%3EA643422653%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2466020553&rft_id=info:pmid/33259500&rft_galeid=A643422653&rft_doaj_id=oai_doaj_org_article_4af6277e05f04bf28fcd0f8967510c7a&rfr_iscdi=true |