Genetic and reproductive consequences of consanguineous marriage in Bangladesh
This study aimed to assess the prevalence, sociodemographic factors, reproductive consequences, and heritable disease burdens associated with consanguineous marriage (CM) in Bangladesh. A total of 7,312 families, including 3,694 CM-families, were recruited from 102 locales of 58 districts of Banglad...
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| creator | Anwar, Saeed Taslem Mourosi, Jarin Arafat, Yasir Hosen, Mohammad Jakir |
| description | This study aimed to assess the prevalence, sociodemographic factors, reproductive consequences, and heritable disease burdens associated with consanguineous marriage (CM) in Bangladesh.
A total of 7,312 families, including 3,694 CM-families, were recruited from 102 locales of 58 districts of Bangladesh. Using a standard questionnaire, we collected medical history and background sociodemographic data of these families. Family history was assessed by pedigree analysis. Fertility, mortality, secondary sex ratio, selection intensity, lethal equivalents were measured using standard methods.
The mean prevalence of CM in our studied population was 6.64%. Gross fertility was higher among CM families, as compared to the non-CM families (p < 0.05). The rate of under-5 child (U5) mortality was significantly higher among CM families (16.6%) in comparison with the non-CM families (5.8%) (p < 0.01). We observed a persuasive rise of abortion/miscarriage and U5 mortality rates with the increasing level of inbreeding. The value of lethal equivalents per gamete found elevated for autosomal inheritances as compared to sex-linked inheritance. CM was associated with the incidence of several single-gene and multifactorial diseases, and congenital malformations, including bronchial asthma, hearing defect, heart diseases, sickle cell anemia (p < 0.05). The general attitude and perception toward CM were rather indifferent, and very few people were concerned about its genetic burden.
This study highlights the harmful consequences of CM on reproductive behavior and the incidence of hereditary conditions. It essences the need for genetic counseling from premarital to postnatal levels in Bangladesh. |
| doi_str_mv | 10.1371/journal.pone.0241610 |
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A total of 7,312 families, including 3,694 CM-families, were recruited from 102 locales of 58 districts of Bangladesh. Using a standard questionnaire, we collected medical history and background sociodemographic data of these families. Family history was assessed by pedigree analysis. Fertility, mortality, secondary sex ratio, selection intensity, lethal equivalents were measured using standard methods.
The mean prevalence of CM in our studied population was 6.64%. Gross fertility was higher among CM families, as compared to the non-CM families (p < 0.05). The rate of under-5 child (U5) mortality was significantly higher among CM families (16.6%) in comparison with the non-CM families (5.8%) (p < 0.01). We observed a persuasive rise of abortion/miscarriage and U5 mortality rates with the increasing level of inbreeding. The value of lethal equivalents per gamete found elevated for autosomal inheritances as compared to sex-linked inheritance. CM was associated with the incidence of several single-gene and multifactorial diseases, and congenital malformations, including bronchial asthma, hearing defect, heart diseases, sickle cell anemia (p < 0.05). The general attitude and perception toward CM were rather indifferent, and very few people were concerned about its genetic burden.
This study highlights the harmful consequences of CM on reproductive behavior and the incidence of hereditary conditions. It essences the need for genetic counseling from premarital to postnatal levels in Bangladesh.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0241610</identifier><identifier>PMID: 33253173</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Anemia ; Asthma ; Bangladesh ; Biology and Life Sciences ; Biotechnology ; Cardiovascular diseases ; Child ; Congenital Abnormalities - epidemiology ; Congenital Abnormalities - genetics ; Congenital defects ; Congenital diseases ; Consanguinity ; Coronary artery disease ; Couples ; Equivalence ; Female ; Fertility ; Genetic aspects ; Genetic counseling ; Genetic Diseases, Inborn - epidemiology ; Genetic Diseases, Inborn - genetics ; Genetic disorders ; Genetic engineering ; Genetic research ; Genetic screening ; Genetics ; Health aspects ; Heart diseases ; Humans ; Inbreeding ; Life sciences ; Male ; Marriage ; Marriage customs ; Medicine and Health Sciences ; Mortality ; Mortality - trends ; Multifactorial Inheritance ; Pedigree ; People and Places ; Population ; Population - genetics ; Population studies ; Questionnaires ; Reproductive behavior ; Reproductive Behavior - statistics & numerical data ; Risk factors ; Selection, Genetic ; Sex ; Sex linkage ; Sex ratio ; Sickle cell disease ; Social Sciences ; Variance analysis</subject><ispartof>PloS one, 2020-11, Vol.15 (11), p.e0241610-e0241610</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Anwar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Anwar et al 2020 Anwar et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8a666f06a731acfddb5900108f72eb9be0788ccaca209a0849e22e0a163733a43</citedby><cites>FETCH-LOGICAL-c692t-8a666f06a731acfddb5900108f72eb9be0788ccaca209a0849e22e0a163733a43</cites><orcidid>0000-0001-6444-0214 ; 0000-0003-3688-5923</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703949/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703949/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33253173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cubellis, Maria Vittoria</contributor><creatorcontrib>Anwar, Saeed</creatorcontrib><creatorcontrib>Taslem Mourosi, Jarin</creatorcontrib><creatorcontrib>Arafat, Yasir</creatorcontrib><creatorcontrib>Hosen, Mohammad Jakir</creatorcontrib><title>Genetic and reproductive consequences of consanguineous marriage in Bangladesh</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to assess the prevalence, sociodemographic factors, reproductive consequences, and heritable disease burdens associated with consanguineous marriage (CM) in Bangladesh.
A total of 7,312 families, including 3,694 CM-families, were recruited from 102 locales of 58 districts of Bangladesh. Using a standard questionnaire, we collected medical history and background sociodemographic data of these families. Family history was assessed by pedigree analysis. Fertility, mortality, secondary sex ratio, selection intensity, lethal equivalents were measured using standard methods.
The mean prevalence of CM in our studied population was 6.64%. Gross fertility was higher among CM families, as compared to the non-CM families (p < 0.05). The rate of under-5 child (U5) mortality was significantly higher among CM families (16.6%) in comparison with the non-CM families (5.8%) (p < 0.01). We observed a persuasive rise of abortion/miscarriage and U5 mortality rates with the increasing level of inbreeding. The value of lethal equivalents per gamete found elevated for autosomal inheritances as compared to sex-linked inheritance. CM was associated with the incidence of several single-gene and multifactorial diseases, and congenital malformations, including bronchial asthma, hearing defect, heart diseases, sickle cell anemia (p < 0.05). The general attitude and perception toward CM were rather indifferent, and very few people were concerned about its genetic burden.
This study highlights the harmful consequences of CM on reproductive behavior and the incidence of hereditary conditions. It essences the need for genetic counseling from premarital to postnatal levels in Bangladesh.</description><subject>Adult</subject><subject>Anemia</subject><subject>Asthma</subject><subject>Bangladesh</subject><subject>Biology and Life Sciences</subject><subject>Biotechnology</subject><subject>Cardiovascular diseases</subject><subject>Child</subject><subject>Congenital Abnormalities - epidemiology</subject><subject>Congenital Abnormalities - genetics</subject><subject>Congenital defects</subject><subject>Congenital diseases</subject><subject>Consanguinity</subject><subject>Coronary artery disease</subject><subject>Couples</subject><subject>Equivalence</subject><subject>Female</subject><subject>Fertility</subject><subject>Genetic aspects</subject><subject>Genetic counseling</subject><subject>Genetic Diseases, Inborn - epidemiology</subject><subject>Genetic Diseases, Inborn - genetics</subject><subject>Genetic disorders</subject><subject>Genetic engineering</subject><subject>Genetic research</subject><subject>Genetic screening</subject><subject>Genetics</subject><subject>Health aspects</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Inbreeding</subject><subject>Life sciences</subject><subject>Male</subject><subject>Marriage</subject><subject>Marriage customs</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Mortality - trends</subject><subject>Multifactorial Inheritance</subject><subject>Pedigree</subject><subject>People and Places</subject><subject>Population</subject><subject>Population - genetics</subject><subject>Population studies</subject><subject>Questionnaires</subject><subject>Reproductive behavior</subject><subject>Reproductive Behavior - statistics & numerical data</subject><subject>Risk factors</subject><subject>Selection, Genetic</subject><subject>Sex</subject><subject>Sex linkage</subject><subject>Sex ratio</subject><subject>Sickle cell disease</subject><subject>Social Sciences</subject><subject>Variance analysis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1v1DAQhiMEoqXwDxBEQkJw2MUfiZNckEoFZaWKSnxdrYk9yXqVtRc7qeDf4-ym1Qb1gHJwPH7mHc_4TZLnlCwpL-i7jRu8hW65cxaXhGVUUPIgOaUVZwvBCH949H-SPAlhQ0jOSyEeJyecs5zTgp8mXy7RYm9UClanHnfe6UH15gZT5WzAXwNahSF1zX4Pth2MRTeEdAveG2gxNTb9EOMdaAzrp8mjBrqAz6b1LPnx6eP3i8-Lq-vL1cX51UKJivWLEoQQDRFQcAqq0brOK0IoKZuCYV3VSIqyVAoUMFIBKbMKGUMCVPCCc8j4WfLyoLvrXJDTKIJkmcgLllPOIrE6ENrBRu68iRf-Ix0YuQ8430rwsfEOJdQZ1XWslmckY1VeNYVmOWhaE82rbNR6P1Ub6i1qhbb30M1E5yfWrGXrbmRRkChQRYE3k4B3caShl1sTFHYd7Ic53lsQnrMyj-irf9D7u5uoFmIDxjYu1lWjqDwXGeeU51URqeU9VPw0bk18T2xMjM8S3s4SItPj776FIQS5-vb1_9nrn3P29RG7Ruj6dXDd0JtoqjmYHUDlXQgem7shUyJH299OQ462l5PtY9qL4we6S7r1Of8Lz4D8xg</recordid><startdate>20201130</startdate><enddate>20201130</enddate><creator>Anwar, Saeed</creator><creator>Taslem Mourosi, Jarin</creator><creator>Arafat, Yasir</creator><creator>Hosen, Mohammad Jakir</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6444-0214</orcidid><orcidid>https://orcid.org/0000-0003-3688-5923</orcidid></search><sort><creationdate>20201130</creationdate><title>Genetic and reproductive consequences of consanguineous marriage in Bangladesh</title><author>Anwar, Saeed ; Taslem Mourosi, Jarin ; Arafat, Yasir ; Hosen, Mohammad Jakir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8a666f06a731acfddb5900108f72eb9be0788ccaca209a0849e22e0a163733a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Anemia</topic><topic>Asthma</topic><topic>Bangladesh</topic><topic>Biology and Life Sciences</topic><topic>Biotechnology</topic><topic>Cardiovascular diseases</topic><topic>Child</topic><topic>Congenital Abnormalities - epidemiology</topic><topic>Congenital Abnormalities - genetics</topic><topic>Congenital defects</topic><topic>Congenital diseases</topic><topic>Consanguinity</topic><topic>Coronary artery disease</topic><topic>Couples</topic><topic>Equivalence</topic><topic>Female</topic><topic>Fertility</topic><topic>Genetic aspects</topic><topic>Genetic counseling</topic><topic>Genetic Diseases, Inborn - epidemiology</topic><topic>Genetic Diseases, Inborn - genetics</topic><topic>Genetic disorders</topic><topic>Genetic engineering</topic><topic>Genetic research</topic><topic>Genetic screening</topic><topic>Genetics</topic><topic>Health aspects</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Inbreeding</topic><topic>Life sciences</topic><topic>Male</topic><topic>Marriage</topic><topic>Marriage customs</topic><topic>Medicine and Health Sciences</topic><topic>Mortality</topic><topic>Mortality - trends</topic><topic>Multifactorial Inheritance</topic><topic>Pedigree</topic><topic>People and Places</topic><topic>Population</topic><topic>Population - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anwar, Saeed</au><au>Taslem Mourosi, Jarin</au><au>Arafat, Yasir</au><au>Hosen, Mohammad Jakir</au><au>Cubellis, Maria Vittoria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic and reproductive consequences of consanguineous marriage in Bangladesh</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-11-30</date><risdate>2020</risdate><volume>15</volume><issue>11</issue><spage>e0241610</spage><epage>e0241610</epage><pages>e0241610-e0241610</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to assess the prevalence, sociodemographic factors, reproductive consequences, and heritable disease burdens associated with consanguineous marriage (CM) in Bangladesh.
A total of 7,312 families, including 3,694 CM-families, were recruited from 102 locales of 58 districts of Bangladesh. Using a standard questionnaire, we collected medical history and background sociodemographic data of these families. Family history was assessed by pedigree analysis. Fertility, mortality, secondary sex ratio, selection intensity, lethal equivalents were measured using standard methods.
The mean prevalence of CM in our studied population was 6.64%. Gross fertility was higher among CM families, as compared to the non-CM families (p < 0.05). The rate of under-5 child (U5) mortality was significantly higher among CM families (16.6%) in comparison with the non-CM families (5.8%) (p < 0.01). We observed a persuasive rise of abortion/miscarriage and U5 mortality rates with the increasing level of inbreeding. The value of lethal equivalents per gamete found elevated for autosomal inheritances as compared to sex-linked inheritance. CM was associated with the incidence of several single-gene and multifactorial diseases, and congenital malformations, including bronchial asthma, hearing defect, heart diseases, sickle cell anemia (p < 0.05). The general attitude and perception toward CM were rather indifferent, and very few people were concerned about its genetic burden.
This study highlights the harmful consequences of CM on reproductive behavior and the incidence of hereditary conditions. It essences the need for genetic counseling from premarital to postnatal levels in Bangladesh.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33253173</pmid><doi>10.1371/journal.pone.0241610</doi><tpages>e0241610</tpages><orcidid>https://orcid.org/0000-0001-6444-0214</orcidid><orcidid>https://orcid.org/0000-0003-3688-5923</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Anemia Asthma Bangladesh Biology and Life Sciences Biotechnology Cardiovascular diseases Child Congenital Abnormalities - epidemiology Congenital Abnormalities - genetics Congenital defects Congenital diseases Consanguinity Coronary artery disease Couples Equivalence Female Fertility Genetic aspects Genetic counseling Genetic Diseases, Inborn - epidemiology Genetic Diseases, Inborn - genetics Genetic disorders Genetic engineering Genetic research Genetic screening Genetics Health aspects Heart diseases Humans Inbreeding Life sciences Male Marriage Marriage customs Medicine and Health Sciences Mortality Mortality - trends Multifactorial Inheritance Pedigree People and Places Population Population - genetics Population studies Questionnaires Reproductive behavior Reproductive Behavior - statistics & numerical data Risk factors Selection, Genetic Sex Sex linkage Sex ratio Sickle cell disease Social Sciences Variance analysis |
| title | Genetic and reproductive consequences of consanguineous marriage in Bangladesh |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T09%3A41%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20and%20reproductive%20consequences%20of%20consanguineous%20marriage%20in%20Bangladesh&rft.jtitle=PloS%20one&rft.au=Anwar,%20Saeed&rft.date=2020-11-30&rft.volume=15&rft.issue=11&rft.spage=e0241610&rft.epage=e0241610&rft.pages=e0241610-e0241610&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0241610&rft_dat=%3Cgale_plos_%3EA643313597%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2465725132&rft_id=info:pmid/33253173&rft_galeid=A643313597&rft_doaj_id=oai_doaj_org_article_ab41dbcac54042959f7d25ad1b0d3942&rfr_iscdi=true |