C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19
Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease progression. We conducted a retrospective cohort analysis of the medical records of 268 adult patients, who were admitted to one of the six cohorted COVID ICUs a...
Gespeichert in:
| Veröffentlicht in: | PloS one 2020-11, Vol.15 (11), p.e0242400 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 11 |
| container_start_page | e0242400 |
| container_title | PloS one |
| container_volume | 15 |
| creator | Sharifpour, Milad Rangaraju, Srikant Liu, Michael Alabyad, Darwish Nahab, Fadi B Creel-Bulos, Christina M Jabaley, Craig S |
| description | Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease progression. We conducted a retrospective cohort analysis of the medical records of 268 adult patients, who were admitted to one of the six cohorted COVID ICUs across Emory Healthcare System and had at least two CRP values within the first seven days of admission to study the temporal progression of CRP and its association with all-cause in-hospital mortality. The median CRP during hospitalization for the entire cohort was 130 mg/L (IQR 82-191 mg/L), and the median CRP on ICU admission was 169 (IQR 111-234). The hospitalization-wide median CRP was significantly higher amongst the patients who died, compared to those who survived [206 mg/L (157-288 mg/L) vs 114 mg/L (72-160 mg/L), p |
| doi_str_mv | 10.1371/journal.pone.0242400 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2462635131</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A642356651</galeid><doaj_id>oai_doaj_org_article_b40d5e49d92e46b9ab4816fe59e00682</doaj_id><sourcerecordid>A642356651</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-a6ea848592512a68510ce47feac92b0917d11b98f601a84198d371ba70fbd5813</originalsourceid><addsrcrecordid>eNqNkktv1DAUhSMEoqXwDxBEQkKwyOB34g1SNbxGqjRSC91aTnIz4yoTp7ZTHr8ep5NWE9QFysKv7x773JwkeYnRAtMcf7iyg-t0u-htBwtEGGEIPUqOsaQkEwTRxwfzo-SZ91cIcVoI8TQ5opRgkefsOLlYZuegq2BuIO2dDWC6VPtUj4tNZ30wVWq62lQ6WBdn6db63gTdmj9Qp70OBrrg058mbNPl-nL1KcPyefKk0a2HF9N4kvz48vn78lt2tv66Wp6eZZWQJGRagC5YwSXhmGhRcIwqYHkTnyNJiSTOa4xLWTQC4QhiWdTRd6lz1JQ1LzA9SV7vdfvWejX1wyvCBBGUYzoSqz1RW32lemd22v1WVht1u2HdRmkXLbagSoZqDkzWkgATpdQlK7BogEtASBQkan2cbhvKHdRV9O10OxOdn3Rmqzb2RuUil5ijKPBuEnD2egAf1M74CtpWd2CH23dTJAvGZETf_IM-7G6iNjoaMF1j473VKKpOBSOUC8FHavEAFb8adqaK4WlM3J8VvJ8VRCbAr7DRg_dqdXH-_-z6cs6-PWC3oNuw9bYdgrGdn4NsD1bOeu-guW8yRmrM_l031Jh9NWU_lr06_EH3RXdhp38BteP8Tg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2462635131</pqid></control><display><type>article</type><title>C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19</title><source>MEDLINE</source><source>Public Library of Science</source><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>Free Full-Text Journals in Chemistry</source><source>EZB Electronic Journals Library</source><creator>Sharifpour, Milad ; Rangaraju, Srikant ; Liu, Michael ; Alabyad, Darwish ; Nahab, Fadi B ; Creel-Bulos, Christina M ; Jabaley, Craig S</creator><contributor>Loukides, Stelios</contributor><creatorcontrib>Sharifpour, Milad ; Rangaraju, Srikant ; Liu, Michael ; Alabyad, Darwish ; Nahab, Fadi B ; Creel-Bulos, Christina M ; Jabaley, Craig S ; Emory COVID-19 Quality & Clinical Research Collaborative ; on behalf of the Emory COVID-19 Quality & Clinical Research Collaborative ; Loukides, Stelios</creatorcontrib><description>Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease progression. We conducted a retrospective cohort analysis of the medical records of 268 adult patients, who were admitted to one of the six cohorted COVID ICUs across Emory Healthcare System and had at least two CRP values within the first seven days of admission to study the temporal progression of CRP and its association with all-cause in-hospital mortality. The median CRP during hospitalization for the entire cohort was 130 mg/L (IQR 82-191 mg/L), and the median CRP on ICU admission was 169 (IQR 111-234). The hospitalization-wide median CRP was significantly higher amongst the patients who died, compared to those who survived [206 mg/L (157-288 mg/L) vs 114 mg/L (72-160 mg/L), p<0.001]. CRP levels increased in a linear fashion during the first week of hospitalization and peaked on day 5. Compared to patients who died, those who survived had lower peak CRP levels and earlier declines. CRP levels were significantly higher in patients who died compared to those who survived (p<0.001). Our findings support the utility of daily CRP values in hospitalized COVID-19 patients and provide early thresholds during hospitalization that may facilitate risk stratification and prognostication.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0242400</identifier><identifier>PMID: 33216774</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Anesthesiology ; Betacoronavirus ; Biology and Life Sciences ; Biomarkers - analysis ; Body mass index ; C-reactive protein ; C-Reactive Protein - analysis ; Collaboration ; Comorbidity ; Coronavirus Infections - diagnosis ; Coronavirus Infections - epidemiology ; Coronaviruses ; COVID-19 ; Critical care ; Diagnosis ; Disease ; Female ; Health aspects ; Hospital Mortality ; Hospital patients ; Hospitalization ; Hospitals ; Humans ; Intensive care ; Intubation ; Male ; Medical examination ; Medical prognosis ; Medical records ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Pandemics ; Patients ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - epidemiology ; Prognosis ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Survival ; Trends ; Ventilators</subject><ispartof>PloS one, 2020-11, Vol.15 (11), p.e0242400</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Sharifpour et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Sharifpour et al 2020 Sharifpour et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a6ea848592512a68510ce47feac92b0917d11b98f601a84198d371ba70fbd5813</citedby><cites>FETCH-LOGICAL-c692t-a6ea848592512a68510ce47feac92b0917d11b98f601a84198d371ba70fbd5813</cites><orcidid>0000-0002-4585-6334 ; 0000-0003-4507-0849 ; 0000-0001-6687-3953</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679150/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679150/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2919,23857,27915,27916,53782,53784,79361,79362</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33216774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Loukides, Stelios</contributor><creatorcontrib>Sharifpour, Milad</creatorcontrib><creatorcontrib>Rangaraju, Srikant</creatorcontrib><creatorcontrib>Liu, Michael</creatorcontrib><creatorcontrib>Alabyad, Darwish</creatorcontrib><creatorcontrib>Nahab, Fadi B</creatorcontrib><creatorcontrib>Creel-Bulos, Christina M</creatorcontrib><creatorcontrib>Jabaley, Craig S</creatorcontrib><creatorcontrib>Emory COVID-19 Quality & Clinical Research Collaborative</creatorcontrib><creatorcontrib>on behalf of the Emory COVID-19 Quality & Clinical Research Collaborative</creatorcontrib><title>C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease progression. We conducted a retrospective cohort analysis of the medical records of 268 adult patients, who were admitted to one of the six cohorted COVID ICUs across Emory Healthcare System and had at least two CRP values within the first seven days of admission to study the temporal progression of CRP and its association with all-cause in-hospital mortality. The median CRP during hospitalization for the entire cohort was 130 mg/L (IQR 82-191 mg/L), and the median CRP on ICU admission was 169 (IQR 111-234). The hospitalization-wide median CRP was significantly higher amongst the patients who died, compared to those who survived [206 mg/L (157-288 mg/L) vs 114 mg/L (72-160 mg/L), p<0.001]. CRP levels increased in a linear fashion during the first week of hospitalization and peaked on day 5. Compared to patients who died, those who survived had lower peak CRP levels and earlier declines. CRP levels were significantly higher in patients who died compared to those who survived (p<0.001). Our findings support the utility of daily CRP values in hospitalized COVID-19 patients and provide early thresholds during hospitalization that may facilitate risk stratification and prognostication.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesiology</subject><subject>Betacoronavirus</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - analysis</subject><subject>Body mass index</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Collaboration</subject><subject>Comorbidity</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Critical care</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hospital Mortality</subject><subject>Hospital patients</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intensive care</subject><subject>Intubation</subject><subject>Male</subject><subject>Medical examination</subject><subject>Medical prognosis</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Survival</subject><subject>Trends</subject><subject>Ventilators</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkktv1DAUhSMEoqXwDxBEQkKwyOB34g1SNbxGqjRSC91aTnIz4yoTp7ZTHr8ep5NWE9QFysKv7x773JwkeYnRAtMcf7iyg-t0u-htBwtEGGEIPUqOsaQkEwTRxwfzo-SZ91cIcVoI8TQ5opRgkefsOLlYZuegq2BuIO2dDWC6VPtUj4tNZ30wVWq62lQ6WBdn6db63gTdmj9Qp70OBrrg058mbNPl-nL1KcPyefKk0a2HF9N4kvz48vn78lt2tv66Wp6eZZWQJGRagC5YwSXhmGhRcIwqYHkTnyNJiSTOa4xLWTQC4QhiWdTRd6lz1JQ1LzA9SV7vdfvWejX1wyvCBBGUYzoSqz1RW32lemd22v1WVht1u2HdRmkXLbagSoZqDkzWkgATpdQlK7BogEtASBQkan2cbhvKHdRV9O10OxOdn3Rmqzb2RuUil5ijKPBuEnD2egAf1M74CtpWd2CH23dTJAvGZETf_IM-7G6iNjoaMF1j473VKKpOBSOUC8FHavEAFb8adqaK4WlM3J8VvJ8VRCbAr7DRg_dqdXH-_-z6cs6-PWC3oNuw9bYdgrGdn4NsD1bOeu-guW8yRmrM_l031Jh9NWU_lr06_EH3RXdhp38BteP8Tg</recordid><startdate>20201120</startdate><enddate>20201120</enddate><creator>Sharifpour, Milad</creator><creator>Rangaraju, Srikant</creator><creator>Liu, Michael</creator><creator>Alabyad, Darwish</creator><creator>Nahab, Fadi B</creator><creator>Creel-Bulos, Christina M</creator><creator>Jabaley, Craig S</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>COVID</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4585-6334</orcidid><orcidid>https://orcid.org/0000-0003-4507-0849</orcidid><orcidid>https://orcid.org/0000-0001-6687-3953</orcidid></search><sort><creationdate>20201120</creationdate><title>C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19</title><author>Sharifpour, Milad ; Rangaraju, Srikant ; Liu, Michael ; Alabyad, Darwish ; Nahab, Fadi B ; Creel-Bulos, Christina M ; Jabaley, Craig S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a6ea848592512a68510ce47feac92b0917d11b98f601a84198d371ba70fbd5813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesiology</topic><topic>Betacoronavirus</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers - analysis</topic><topic>Body mass index</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Collaboration</topic><topic>Comorbidity</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Critical care</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>Female</topic><topic>Health aspects</topic><topic>Hospital Mortality</topic><topic>Hospital patients</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Intensive care</topic><topic>Intubation</topic><topic>Male</topic><topic>Medical examination</topic><topic>Medical prognosis</topic><topic>Medical records</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - epidemiology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Survival</topic><topic>Trends</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharifpour, Milad</creatorcontrib><creatorcontrib>Rangaraju, Srikant</creatorcontrib><creatorcontrib>Liu, Michael</creatorcontrib><creatorcontrib>Alabyad, Darwish</creatorcontrib><creatorcontrib>Nahab, Fadi B</creatorcontrib><creatorcontrib>Creel-Bulos, Christina M</creatorcontrib><creatorcontrib>Jabaley, Craig S</creatorcontrib><creatorcontrib>Emory COVID-19 Quality & Clinical Research Collaborative</creatorcontrib><creatorcontrib>on behalf of the Emory COVID-19 Quality & Clinical Research Collaborative</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharifpour, Milad</au><au>Rangaraju, Srikant</au><au>Liu, Michael</au><au>Alabyad, Darwish</au><au>Nahab, Fadi B</au><au>Creel-Bulos, Christina M</au><au>Jabaley, Craig S</au><au>Loukides, Stelios</au><aucorp>Emory COVID-19 Quality & Clinical Research Collaborative</aucorp><aucorp>on behalf of the Emory COVID-19 Quality & Clinical Research Collaborative</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-11-20</date><risdate>2020</risdate><volume>15</volume><issue>11</issue><spage>e0242400</spage><pages>e0242400-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease progression. We conducted a retrospective cohort analysis of the medical records of 268 adult patients, who were admitted to one of the six cohorted COVID ICUs across Emory Healthcare System and had at least two CRP values within the first seven days of admission to study the temporal progression of CRP and its association with all-cause in-hospital mortality. The median CRP during hospitalization for the entire cohort was 130 mg/L (IQR 82-191 mg/L), and the median CRP on ICU admission was 169 (IQR 111-234). The hospitalization-wide median CRP was significantly higher amongst the patients who died, compared to those who survived [206 mg/L (157-288 mg/L) vs 114 mg/L (72-160 mg/L), p<0.001]. CRP levels increased in a linear fashion during the first week of hospitalization and peaked on day 5. Compared to patients who died, those who survived had lower peak CRP levels and earlier declines. CRP levels were significantly higher in patients who died compared to those who survived (p<0.001). Our findings support the utility of daily CRP values in hospitalized COVID-19 patients and provide early thresholds during hospitalization that may facilitate risk stratification and prognostication.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33216774</pmid><doi>10.1371/journal.pone.0242400</doi><orcidid>https://orcid.org/0000-0002-4585-6334</orcidid><orcidid>https://orcid.org/0000-0003-4507-0849</orcidid><orcidid>https://orcid.org/0000-0001-6687-3953</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-11, Vol.15 (11), p.e0242400 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2462635131 |
| source | MEDLINE; Public Library of Science; PubMed Central; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adult Aged Anesthesiology Betacoronavirus Biology and Life Sciences Biomarkers - analysis Body mass index C-reactive protein C-Reactive Protein - analysis Collaboration Comorbidity Coronavirus Infections - diagnosis Coronavirus Infections - epidemiology Coronaviruses COVID-19 Critical care Diagnosis Disease Female Health aspects Hospital Mortality Hospital patients Hospitalization Hospitals Humans Intensive care Intubation Male Medical examination Medical prognosis Medical records Medicine and Health Sciences Middle Aged Mortality Pandemics Patients Pneumonia, Viral - diagnosis Pneumonia, Viral - epidemiology Prognosis Retrospective Studies Risk Factors SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Survival Trends Ventilators |
| title | C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T18%3A02%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=C-Reactive%20protein%20as%20a%20prognostic%20indicator%20in%20hospitalized%20patients%20with%20COVID-19&rft.jtitle=PloS%20one&rft.au=Sharifpour,%20Milad&rft.aucorp=Emory%20COVID-19%20Quality%20&%20Clinical%20Research%20Collaborative&rft.date=2020-11-20&rft.volume=15&rft.issue=11&rft.spage=e0242400&rft.pages=e0242400-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0242400&rft_dat=%3Cgale_plos_%3EA642356651%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2462635131&rft_id=info:pmid/33216774&rft_galeid=A642356651&rft_doaj_id=oai_doaj_org_article_b40d5e49d92e46b9ab4816fe59e00682&rfr_iscdi=true |