In utero exposure to protease inhibitor-based antiretroviral regimens delays growth and developmental milestones in mice

Antiretroviral therapy (ART) in pregnancy has dramatically reduced HIV vertical transmission rates. Consequently, there is a growing number of children that are HIV exposed uninfected (CHEUs). Studies suggest that CHEUs exposed in utero to ART may experience developmental delays compared to their pe...

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Veröffentlicht in:	PloS one 2020-11, Vol.15 (11), p.e0242513
Hauptverfasser:	Sarkar, Ambalika, Balogun, Kayode, Guzman Lenis, Monica S, Acosta, Sebastian, Mount, Howard T, Serghides, Lena
Format:	Artikel
Sprache:	eng
Schlagworte:	Abacavir Age Animal cognition Animals Anti-HIV Agents - administration & dosage Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Atazanavir Sulfate - administration & dosage Atazanavir Sulfate - toxicity Aversion Biology and Life Sciences Child development Cliffs Complications and side effects Developmental delay Developmental Disabilities - chemically induced Dideoxynucleosides - administration & dosage Dideoxynucleosides - toxicity Disease transmission Ear Emtricitabine Emtricitabine - administration & dosage Emtricitabine - toxicity Enzyme inhibitors Exploratory Behavior - drug effects Exposure Female Females Fetal Growth Retardation - chemically induced Field tests Geotaxis Growth Disorders - chemically induced Hand Strength Health aspects Health care networks Highly active antiretroviral therapy HIV HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - toxicity Homing Behavior - drug effects Hospitals Human immunodeficiency virus Infants Intrauterine exposure Juveniles Laboratories Lamivudine Lamivudine - administration & dosage Lamivudine - toxicity Male Males Medicine and Health Sciences Mice Mice, Inbred C57BL Neonates Offspring Open-field behavior Pediatric research Performance assessment Perinatal exposure Physiological aspects Pregnancy Prenatal drug exposure Prenatal Exposure Delayed Effects Protease inhibitors Proteinase inhibitors Random Allocation Reflex, Abnormal Reflex, Righting - drug effects Reflexes Risk factors Rooting Sensation Disorders - chemically induced Social Sciences Taxis Response - drug effects Tenofovir Tenofovir - administration & dosage Tenofovir - toxicity Vestibular system
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