Declining antibody levels to Trypanosoma cruzi correlate with polymerase chain reaction positivity and electrocardiographic changes in a retrospective cohort of untreated Brazilian blood donors

Although infection with Trypanosoma cruzi is thought to be lifelong, less than half of those infected develop cardiomyopathy, suggesting greater parasite control or even clearance. Antibody levels appear to correlate with T. cruzi (antigen) load. We test the association between a downwards antibody...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-10, Vol.14 (10), p.e0008787-e0008787
Hauptverfasser:	Buss, Lewis F, Campos de Oliveira-da Silva, Léa, Moreira, Carlos H V, Manuli, Erika R, Sales, Flavia C, Morales, Ingra, Di Germanio, Clara, de Almeida-Neto, Cesar, Bakkour, Sonia, Constable, Paul, Pinto-Filho, Marcelo M, Ribeiro, Antonio L, Busch, Michael, Sabino, Ester C
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adult Aged Antibodies Antibodies, Protozoan - blood Antigens Asymptomatic Biology and Life Sciences Blood Blood & organ donations Blood donors Blood Donors - statistics & numerical data Brazil Carbon monoxide Cardiomyopathy Care and treatment Chagas disease Chagas Disease - blood Chagas Disease - parasitology Cohorts Diagnosis DNA DNA, Protozoan - blood DNA, Protozoan - genetics EKG Electrocardiography Falling Female Follow-Up Studies Humans Immune response Internal medicine Levels Male Malformations Medicine Medicine and Health Sciences Middle Aged Nucleotide sequence Parasite control Parasites PCR Phenotypes Polymerase Chain Reaction Research and Analysis Methods Retrospective Studies Serology Telemedicine Testing Thermal cycling Tropical diseases Trypanosoma cruzi Trypanosoma cruzi - genetics Trypanosoma cruzi - immunology Trypanosoma cruzi - isolation & purification Vector-borne diseases Viral antibodies
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