Urine-based antigen detection assay for diagnosis of visceral leishmaniasis using monoclonal antibodies specific for six protein biomarkers of Leishmania infantum / Leishmania donovani

The development of an accurate protein-based antigen detection assay for diagnosis of active visceral leishmaniasis (VL) would represent a major clinical advance. VL is a serious and fatal disease caused by the parasites Leishmania infantum and Leishmania donovani. The gold standard confirmatory dia...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-04, Vol.14 (4), p.e0008246-e0008246
Hauptverfasser:	Abeijon, Claudia, Alves, Fabiana, Monnerat, Séverine, Mbui, Jane, Viana, Agostinho G, Almeida, Raquel M, Bueno, Lilian L, Fujiwara, Ricardo T, Campos-Neto, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Agglutination tests Antibodies Antibodies, Monoclonal - immunology Antibodies, Protozoan - immunology Antigens Antigens, Protozoan - immunology Antigens, Protozoan - urine Biological markers Biology and Life Sciences Biomarkers Biomarkers - urine Bone marrow Buffy coat Chagas disease Child Child, Preschool Chromatography Cloning Cutaneous leishmaniasis Data analysis Deoxyribonucleic acid Detection Diagnosis Diagnostic systems Diseases DNA ELISA Enzyme-linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - methods Ethics Female Humans Identification and classification Laboratories Leishmania donovani Leishmania donovani - chemistry Leishmania infantum Leishmania infantum - chemistry Leishmaniasis, Visceral - diagnosis Lymph Lymph nodes Male Medical treatment Medicine and Health Sciences Methods Middle Aged Monoclonal antibodies Multiplexing Parasites Parasitic diseases Peptides Proteins Research and Analysis Methods Schistosomiasis Sensitivity and Specificity Serology Spleen Supervision Tropical climate Tropical diseases Tuberculosis Urinalysis Urinalysis - methods Urine Urine - chemistry Vector-borne diseases Visceral leishmaniasis Young Adult
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