Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population

Leprosy is a chronic infectious disease, caused by Mycobacterium leprae, which affects skin and peripheral nerves. Polymorphisms in genes associated with autophagy, metabolism, innate and adaptive immunity confer susceptibility to leprosy. However, these associations need to be confirmed through ind...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-05, Vol.14 (5), p.e0008247-e0008247
Hauptverfasser:	Leturiondo, André Luiz, Noronha, Ariani Batista, Mendonça, Carla Yael Ribeiro, Ferreira, Cynthia de Oliveira, Alvarado-Arnez, Lucia Elena, Manta, Fernanda Saloum de Neves, Bezerra, Ohanna Cavalcanti de Lima, Carvalho, Elizeu Fagundes de, Moraes, Milton Ozório, Rodrigues, Fabíola da Costa, Talhari, Carolina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adult Age Aged Autophagy Biology and Life Sciences Brazil Case-Control Studies Cell receptors Defence mechanisms Demographic aspects Deoxyribonucleic acid Design Disease resistance DNA Ethnic factors Ethnic groups Female Gender Gene polymorphism Genes Genetic aspects Genetic Predisposition to Disease Genotypes Genotyping Genotyping Techniques Health aspects Humans Immune response Immune system Immunity Infectious diseases Interferon gamma Interferon-gamma - genetics Interleukin 1 Interleukin 10 Interleukin 6 Leprosy Leprosy - genetics LRRK2 protein Male Medicine and Health Sciences Metabolism Middle Aged Minority & ethnic groups Nerves NOD2 protein Nod2 Signaling Adaptor Protein - genetics Nucleotides People and places Peripheral nerves Phagocytosis Physiological aspects Polymorphism Polymorphism, Single Nucleotide Population Regression analysis Single nucleotide polymorphisms Single-nucleotide polymorphism Skin Software Statistical analysis TLR1 protein Toll-like receptors Tropical diseases Tumor necrosis factor Tyk2 protein Young Adult
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