$High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches$

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

Snakebite is a neglected tropical disease that results in a variety of systemic and local pathologies in envenomed victims and is responsible for around 138,000 deaths every year. Many snake venoms cause severe coagulopathy that makes victims vulnerable to suffering life-threating haemorrhage. The m...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-04, Vol.14 (4), p.e0007802-e0007802
Hauptverfasser:	Slagboom, Julien, Mladić, Marija, Xie, Chunfang, Kazandjian, Taline D, Vonk, Freek, Somsen, Govert W, Casewell, Nicholas R, Kool, Jeroen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Anticoagulants Anticoagulants - analysis Bioassays Biological activity Biological assays Biological Factors - analysis Biology and Life Sciences Blood Coagulation - drug effects Chemical Fractionation Chemical properties Chromatography, Liquid Coagulants - analysis Coagulation Column chromatography Drug dosages Fatalities Fractionation Freeze drying Haemorrhage Hemorrhage High-throughput screening High-throughput screening (Biochemical assaying) Humans Identification Identification and classification Identification methods Liquid chromatography Mass spectrometry Mass spectroscopy Medicine and Health Sciences Metalloproteinase Methods Monoclonal antibodies Peptides Peptides - analysis Phospholipase Phospholipase A2 Physiological aspects Plasma - drug effects Proteins Proteins - analysis Proteomics Research and Analysis Methods Screening Serine Serine proteinase Snake bites Snake Venoms - chemistry Snakes Software Species diversity Spectroscopy Supervision Tandem Mass Spectrometry Taxonomy Toxins Tropical climate Tropical diseases Venom Venom toxins Venoms Vulnerability
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