Molecular characterization of a Trichinella spiralis aspartic protease and its facilitation role in larval invasion of host intestinal epithelial cells

T. spiralis aspartic protease has been identified in excretion/secretion (ES) proteins, but its roles in larval invasion are unclear. The aim of this study was to characterize T. spiralis aspartic protease-2 (TsASP2) and assess its roles in T. spiralis invasion into intestinal epithelial cells (IECs...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-04, Vol.14 (4), p.e0008269-e0008269
Hauptverfasser:	Xu, Jia, Liu, Ruo Dan, Bai, Sheng Jie, Hao, Hui Nan, Yue, Wen Wen, Xu, Yang Xiu Yue, Long, Shao Rong, Cui, Jing, Wang, Zhong Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal embryos Antigens Aspartic endopeptidase Biology and life sciences Cells Collagen Embryos Enzymatic activity Enzyme activity Enzymes Epithelial cells Excretion Fecundity Females Gene expression Genes Genetic aspects Health aspects Hemoglobin Hindgut Host-parasite relationships Immunoglobulin M Intestine Intestines Invasive species Larvae Medical research Medical schools Medicine and Health Sciences Midgut Muscles Observations Parasites Parasitology Pathogens Physiological aspects Protease Proteases Proteins Proteolysis Recombinants Research and Analysis Methods RNA-mediated interference Secretion Serum siRNA Transcription Transfection Trichina worm Tropical diseases Vaccines
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