Identification of prognostic genes in uveal melanoma microenvironment

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Many previous studies have demonstrated that the infiltrating of immune and stromal cells in the tumor microenvironment contributes significantly to prognosis. Dataset TCGA-UVM, download from TCGA portal, was taken as t...

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Veröffentlicht in:	PloS one 2020-11, Vol.15 (11), p.e0242263-e0242263
Hauptverfasser:	Luo, Huan, Ma, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biology and Life Sciences Cancer CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Chromosome 3 Chromosome 8 Chromosomes Chromosomes, Human, Pair 3 - genetics Chromosomes, Human, Pair 8 - genetics Colorectal cancer Correlation analysis Databases, Genetic Development and progression Eye cancer Eye Neoplasms - genetics Eye Neoplasms - mortality Eye Neoplasms - pathology Female Gene expression Gene Expression Regulation, Neoplastic Gene mutation Genes Genetic aspects Genomes Health aspects Humans Identification and classification Immune system Infiltration Infiltration analysis Interleukin 1 Lymphocytes T Lymphocytes, Tumor-Infiltrating - cytology Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Male Malignancy Medical prognosis Medicine and Health Sciences Melanoma Melanoma - genetics Melanoma - pathology Metastases Metastasis Middle Aged Mutation Neoplasm Metastasis Neutrophils - cytology Neutrophils - immunology Neutrophils - metabolism Ontology Pathogenesis Prognosis Proportional Hazards Models Regression analysis Regression models Serpins - genetics Stromal cells Survival analysis Training Tumor Microenvironment Tumor-infiltrating lymphocytes Tumors Ubiquitin-Protein Ligases - genetics Uveal Neoplasms - genetics Uveal Neoplasms - pathology
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