Chaperone-tip adhesin complex is vital for synergistic activation of CFA/I fimbriae biogenesis

Colonization factor CFA/I defines the major adhesive fimbriae of enterotoxigenic Escherichia coli and mediates bacterial attachment to host intestinal epithelial cells. The CFA/I fimbria consists of a tip-localized minor adhesive subunit, CfaE, and thousands of copies of the major subunit CfaB polym...

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Veröffentlicht in:	PLoS pathogens 2020-10, Vol.16 (10), p.e1008848-e1008848
Hauptverfasser:	He, Li-Hui, Wang, Hao, Liu, Yang, Kang, Mei, Li, Tao, Li, Chang-Cheng, Tong, Ai-Ping, Zhu, Yi-Bo, Song, Ying-Jie, Savarino, Stephen J, Prouty, Michael G, Xia, Di, Bao, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesins Adhesins, Bacterial - metabolism Adhesion adhesives Amino Acid Sequence Assembly Bacteria Bacterial proteins BASIC BIOLOGICAL SCIENCES Biology and Life Sciences Biosynthesis Cell adhesion Colonization Colonization factor Crystal structure Cytoplasm E coli Enterotoxigenic Escherichia coli - physiology Epithelial cells Escherichia coli Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fimbriae Proteins - genetics Fimbriae Proteins - metabolism Fimbriae, Bacterial - physiology glycerol imidazole Intestine Medicine and Health Sciences Microbiological synthesis Molecular chaperones Molecular Chaperones - genetics Molecular Chaperones - metabolism Physical Sciences Physiological aspects Pili Pili and fimbirae Polymerization Polymers Protein Conformation Proteins Research and Analysis Methods sequence alignment Sequence Homology, Amino Acid Structure
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