Crystal structures of Triosephosphate Isomerases from Taenia solium and Schistosoma mansoni provide insights for vaccine rationale and drug design against helminth parasites

Triosephosphate isomerases (TPIs) from Taenia solium (TsTPI) and Schistosoma mansoni (SmTPI) are potential vaccine and drug targets against cysticercosis and schistosomiasis, respectively. This is due to the dependence of parasitic helminths on glycolysis and because those proteins elicit an immune...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-01, Vol.14 (1), p.e0007815-e0007815
Hauptverfasser:	Jimenez-Sandoval, Pedro, Castro-Torres, Eduardo, González-González, Rogelio, Díaz-Quezada, Corina, Gurrola, Misraim, Camacho-Manriquez, Laura D, Leyva-Navarro, Lucia, Brieba, Luis G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Biology and Life Sciences Catalysis Catalysts Cell adhesion & migration Crystal structure Crystallography, X-Ray Cysticercosis Defence mechanisms Dimers Disease control Drug Design Drug development Drugs E coli Enzyme kinetics Epitopes Epitopes - chemistry Glycolysis Helices Helminth Proteins - chemistry Immune response Immune system Immunity Immunology Infections Inserts Isomerases Localization Medicine and Health Sciences Metabolism Nematodes Parasites Physical Sciences Proteins Schistosoma mansoni Schistosoma mansoni - enzymology Schistosomiasis Solvents Structures Taenia solium Taenia solium - enzymology Therapeutic targets Triose-Phosphate Isomerase - chemistry Tropical diseases Vaccine development Vaccines
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