Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis
Preventive chemotherapy is a useful tool for the control of Taenia solium taeniasis and cysticercosis. The aim of this systematic review is to assess the scientific evidence concerning the effectiveness and safety of different drugs in preventive chemotherapy for T. solium taeniasis in endemic popul...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2020-01, Vol.14 (1), p.e0007873 |
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| creator | Haby, Michelle M Sosa Leon, Leopoldo A Luciañez, Ana Nicholls, Ruben Santiago Reveiz, Ludovic Donadeu, Meritxell |
| description | Preventive chemotherapy is a useful tool for the control of Taenia solium taeniasis and cysticercosis. The aim of this systematic review is to assess the scientific evidence concerning the effectiveness and safety of different drugs in preventive chemotherapy for T. solium taeniasis in endemic populations.
A systematic review was conducted of controlled and uncontrolled studies, assessing the efficacy and adverse effects (among other outcomes) of albendazole, niclosamide and/or praziquantel for preventive chemotherapy of T. solium taeniasis. A comprehensive search was conducted for published and unpublished studies. Two reviewers screened articles, completed the data extraction and assessment of risk of bias. A meta-analysis of cure rate and relative reduction in prevalence was performed. The protocol for this review was registered on the International prospective register of systematic reviews (PROSPERO), number CRD42018112533.
We identified 3555 records, of which we included 20 primary studies reported across 33 articles. Meta-analyses of drug and dose showed that a single dose of praziquantel 10mg/kg, albendazole 400mg per day for three consecutive days, or niclosamide 2g, resulted in better cure rates for T. solium taeniasis (99.5%, 96.4% and 84.3%, respectively) than praziquantel 5mg/kg or single dose albendazole 400mg (89.0% and 52.0%, respectively). These findings have a low certainty of evidence due to high risk of bias in individual studies and heterogeneity in combined estimates. In relation to side-effects, most studies reported either no or only mild and transient side-effects within the first three days following drug administration for all drugs and doses.
Evidence indicated that praziquantel 10mg/kg, niclosamide 2g, and triple dose albendazole 400mg were effective as taenicides and could be considered for use in mass drug administration programs for the control of T. solium taeniasis. Evidence was not found that any of these drugs caused severe side effects at the indicated doses, although the extent of the available evidence was limited. |
| doi_str_mv | 10.1371/journal.pntd.0007873 |
| format | Article |
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A systematic review was conducted of controlled and uncontrolled studies, assessing the efficacy and adverse effects (among other outcomes) of albendazole, niclosamide and/or praziquantel for preventive chemotherapy of T. solium taeniasis. A comprehensive search was conducted for published and unpublished studies. Two reviewers screened articles, completed the data extraction and assessment of risk of bias. A meta-analysis of cure rate and relative reduction in prevalence was performed. The protocol for this review was registered on the International prospective register of systematic reviews (PROSPERO), number CRD42018112533.
We identified 3555 records, of which we included 20 primary studies reported across 33 articles. Meta-analyses of drug and dose showed that a single dose of praziquantel 10mg/kg, albendazole 400mg per day for three consecutive days, or niclosamide 2g, resulted in better cure rates for T. solium taeniasis (99.5%, 96.4% and 84.3%, respectively) than praziquantel 5mg/kg or single dose albendazole 400mg (89.0% and 52.0%, respectively). These findings have a low certainty of evidence due to high risk of bias in individual studies and heterogeneity in combined estimates. In relation to side-effects, most studies reported either no or only mild and transient side-effects within the first three days following drug administration for all drugs and doses.
Evidence indicated that praziquantel 10mg/kg, niclosamide 2g, and triple dose albendazole 400mg were effective as taenicides and could be considered for use in mass drug administration programs for the control of T. solium taeniasis. Evidence was not found that any of these drugs caused severe side effects at the indicated doses, although the extent of the available evidence was limited.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0007873</identifier><identifier>PMID: 31945055</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Albendazole ; Albendazole - therapeutic use ; Animals ; Anticestodal Agents - therapeutic use ; Bias ; Blood-brain barrier ; Chemoprevention - methods ; Chemotherapy ; Cysticercosis ; Cysticercosis - drug therapy ; Cysticercosis - prevention & control ; Cysts ; Disease prevention ; Dosage ; Drug dosages ; Drugs ; Heterogeneity ; Hogs ; Humans ; Infections ; Infectious diseases ; Literature reviews ; Medicine and Health Sciences ; Nervous system ; Niclosamide ; Niclosamide - therapeutic use ; Parasites ; Population ; Praziquantel ; Praziquantel - therapeutic use ; Protocols ; Research and Analysis Methods ; Reviews ; Risk assessment ; Side effects ; Systematic review ; Taenia solium ; Taenia solium - drug effects ; Taeniasis - drug therapy ; Taeniasis - prevention & control ; Tropical diseases ; Womens health ; Worms</subject><ispartof>PLoS neglected tropical diseases, 2020-01, Vol.14 (1), p.e0007873</ispartof><rights>2020 Pan American Health Organization, Regional Office for the Americas of the World Health Organization. This is an open access article distributed under the terms of the Creative Commons Attribution IGO License (http://creativecommons.org/license: http://creativecommons.org/licenses/by/3.0/igo/legalcode (the “License”)s/by/3.0/igo/legalcode), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any reproduction of this article there should not be any suggestion that PAHO or this article endorse any specific organization or products. The use of the PAHO logo is not permitted. This notice should be preserved along with the article's original URL. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Pan American Health Organization, Regional Office for the Americas of the World Health Organization 2020 Pan American Health Organization, Regional Office for the Americas of the World Health Organization</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-e580a13e025bece382d1e8c3784956743b60e8eb866e18c42493bd46822a59533</citedby><cites>FETCH-LOGICAL-c526t-e580a13e025bece382d1e8c3784956743b60e8eb866e18c42493bd46822a59533</cites><orcidid>0000-0002-2444-914X ; 0000-0001-6203-9195</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964831/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964831/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31945055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Taylan Ozkan, Aysegul</contributor><creatorcontrib>Haby, Michelle M</creatorcontrib><creatorcontrib>Sosa Leon, Leopoldo A</creatorcontrib><creatorcontrib>Luciañez, Ana</creatorcontrib><creatorcontrib>Nicholls, Ruben Santiago</creatorcontrib><creatorcontrib>Reveiz, Ludovic</creatorcontrib><creatorcontrib>Donadeu, Meritxell</creatorcontrib><title>Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Preventive chemotherapy is a useful tool for the control of Taenia solium taeniasis and cysticercosis. The aim of this systematic review is to assess the scientific evidence concerning the effectiveness and safety of different drugs in preventive chemotherapy for T. solium taeniasis in endemic populations.
A systematic review was conducted of controlled and uncontrolled studies, assessing the efficacy and adverse effects (among other outcomes) of albendazole, niclosamide and/or praziquantel for preventive chemotherapy of T. solium taeniasis. A comprehensive search was conducted for published and unpublished studies. Two reviewers screened articles, completed the data extraction and assessment of risk of bias. A meta-analysis of cure rate and relative reduction in prevalence was performed. The protocol for this review was registered on the International prospective register of systematic reviews (PROSPERO), number CRD42018112533.
We identified 3555 records, of which we included 20 primary studies reported across 33 articles. Meta-analyses of drug and dose showed that a single dose of praziquantel 10mg/kg, albendazole 400mg per day for three consecutive days, or niclosamide 2g, resulted in better cure rates for T. solium taeniasis (99.5%, 96.4% and 84.3%, respectively) than praziquantel 5mg/kg or single dose albendazole 400mg (89.0% and 52.0%, respectively). These findings have a low certainty of evidence due to high risk of bias in individual studies and heterogeneity in combined estimates. In relation to side-effects, most studies reported either no or only mild and transient side-effects within the first three days following drug administration for all drugs and doses.
Evidence indicated that praziquantel 10mg/kg, niclosamide 2g, and triple dose albendazole 400mg were effective as taenicides and could be considered for use in mass drug administration programs for the control of T. solium taeniasis. Evidence was not found that any of these drugs caused severe side effects at the indicated doses, although the extent of the available evidence was limited.</description><subject>Albendazole</subject><subject>Albendazole - therapeutic use</subject><subject>Animals</subject><subject>Anticestodal Agents - therapeutic use</subject><subject>Bias</subject><subject>Blood-brain barrier</subject><subject>Chemoprevention - methods</subject><subject>Chemotherapy</subject><subject>Cysticercosis</subject><subject>Cysticercosis - drug therapy</subject><subject>Cysticercosis - prevention & control</subject><subject>Cysts</subject><subject>Disease prevention</subject><subject>Dosage</subject><subject>Drug dosages</subject><subject>Drugs</subject><subject>Heterogeneity</subject><subject>Hogs</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Literature reviews</subject><subject>Medicine and Health Sciences</subject><subject>Nervous system</subject><subject>Niclosamide</subject><subject>Niclosamide - therapeutic use</subject><subject>Parasites</subject><subject>Population</subject><subject>Praziquantel</subject><subject>Praziquantel - therapeutic use</subject><subject>Protocols</subject><subject>Research and Analysis Methods</subject><subject>Reviews</subject><subject>Risk assessment</subject><subject>Side effects</subject><subject>Systematic review</subject><subject>Taenia solium</subject><subject>Taenia solium - drug effects</subject><subject>Taeniasis - drug therapy</subject><subject>Taeniasis - prevention & control</subject><subject>Tropical diseases</subject><subject>Womens health</subject><subject>Worms</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp1Uk1r3DAUFKElSdP8g9AKet6tvi1dCiX0IxDooelZyPLzrhbbciV7w_772rtOSA49SZo3M-_pMQjdULKmvKCfd3FMnWvWfTdUa0JIoQt-hi6p4XLFCi7fvLhfoHc57wiRRmp6ji44NUISKS9R__uQB2jdEDxOsA_wiGONhy1gqGvwQ9hDBznPYIZmAqDCVRo3Gdcx4X6SQDeTsN9CGyddcv3hWHtw0AWHc2zC2OLh-Mohv0dva9dkuF7OK_Tn-7eH25-r-18_7m6_3q-8ZGpYgdTEUQ6EyRI8cM0qCtrzQgsjVSF4qQhoKLVSQLUXTBheVkJpxtz0S86v0MeTb9_EbJdlZcuEIkZzYmbG3YlRRbezfQqtSwcbXbBHIKaNdWnaSwPWCKCO0UIx5UXJCye5Ko2ujaicLvXs9WXpNpYtVH5aSnLNK9PXlS5s7SburTJKaE4ng0-LQYp_R8jDf0YWJ5ZPMecE9XMHSuyciieVnVNhl1RMsg8vp3sWPcWA_wNmIbeI</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Haby, Michelle M</creator><creator>Sosa Leon, Leopoldo A</creator><creator>Luciañez, Ana</creator><creator>Nicholls, Ruben Santiago</creator><creator>Reveiz, Ludovic</creator><creator>Donadeu, Meritxell</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2444-914X</orcidid><orcidid>https://orcid.org/0000-0001-6203-9195</orcidid></search><sort><creationdate>20200101</creationdate><title>Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis</title><author>Haby, Michelle M ; Sosa Leon, Leopoldo A ; Luciañez, Ana ; Nicholls, Ruben Santiago ; Reveiz, Ludovic ; Donadeu, Meritxell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-e580a13e025bece382d1e8c3784956743b60e8eb866e18c42493bd46822a59533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Albendazole</topic><topic>Albendazole - therapeutic use</topic><topic>Animals</topic><topic>Anticestodal Agents - therapeutic use</topic><topic>Bias</topic><topic>Blood-brain barrier</topic><topic>Chemoprevention - methods</topic><topic>Chemotherapy</topic><topic>Cysticercosis</topic><topic>Cysticercosis - drug therapy</topic><topic>Cysticercosis - prevention & control</topic><topic>Cysts</topic><topic>Disease prevention</topic><topic>Dosage</topic><topic>Drug dosages</topic><topic>Drugs</topic><topic>Heterogeneity</topic><topic>Hogs</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Literature reviews</topic><topic>Medicine and Health Sciences</topic><topic>Nervous system</topic><topic>Niclosamide</topic><topic>Niclosamide - therapeutic use</topic><topic>Parasites</topic><topic>Population</topic><topic>Praziquantel</topic><topic>Praziquantel - therapeutic use</topic><topic>Protocols</topic><topic>Research and Analysis Methods</topic><topic>Reviews</topic><topic>Risk assessment</topic><topic>Side effects</topic><topic>Systematic review</topic><topic>Taenia solium</topic><topic>Taenia solium - 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The aim of this systematic review is to assess the scientific evidence concerning the effectiveness and safety of different drugs in preventive chemotherapy for T. solium taeniasis in endemic populations.
A systematic review was conducted of controlled and uncontrolled studies, assessing the efficacy and adverse effects (among other outcomes) of albendazole, niclosamide and/or praziquantel for preventive chemotherapy of T. solium taeniasis. A comprehensive search was conducted for published and unpublished studies. Two reviewers screened articles, completed the data extraction and assessment of risk of bias. A meta-analysis of cure rate and relative reduction in prevalence was performed. The protocol for this review was registered on the International prospective register of systematic reviews (PROSPERO), number CRD42018112533.
We identified 3555 records, of which we included 20 primary studies reported across 33 articles. Meta-analyses of drug and dose showed that a single dose of praziquantel 10mg/kg, albendazole 400mg per day for three consecutive days, or niclosamide 2g, resulted in better cure rates for T. solium taeniasis (99.5%, 96.4% and 84.3%, respectively) than praziquantel 5mg/kg or single dose albendazole 400mg (89.0% and 52.0%, respectively). These findings have a low certainty of evidence due to high risk of bias in individual studies and heterogeneity in combined estimates. In relation to side-effects, most studies reported either no or only mild and transient side-effects within the first three days following drug administration for all drugs and doses.
Evidence indicated that praziquantel 10mg/kg, niclosamide 2g, and triple dose albendazole 400mg were effective as taenicides and could be considered for use in mass drug administration programs for the control of T. solium taeniasis. Evidence was not found that any of these drugs caused severe side effects at the indicated doses, although the extent of the available evidence was limited.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31945055</pmid><doi>10.1371/journal.pntd.0007873</doi><orcidid>https://orcid.org/0000-0002-2444-914X</orcidid><orcidid>https://orcid.org/0000-0001-6203-9195</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PLoS neglected tropical diseases, 2020-01, Vol.14 (1), p.e0007873 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Albendazole Albendazole - therapeutic use Animals Anticestodal Agents - therapeutic use Bias Blood-brain barrier Chemoprevention - methods Chemotherapy Cysticercosis Cysticercosis - drug therapy Cysticercosis - prevention & control Cysts Disease prevention Dosage Drug dosages Drugs Heterogeneity Hogs Humans Infections Infectious diseases Literature reviews Medicine and Health Sciences Nervous system Niclosamide Niclosamide - therapeutic use Parasites Population Praziquantel Praziquantel - therapeutic use Protocols Research and Analysis Methods Reviews Risk assessment Side effects Systematic review Taenia solium Taenia solium - drug effects Taeniasis - drug therapy Taeniasis - prevention & control Tropical diseases Womens health Worms |
| title | Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis |
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