Bacteria under antibiotic attack: Different strategies for evolutionary adaptation
Bacteria are well known for their extremely high adaptability in stressful environments. The clinical relevance of this property is clearly illustrated by the ever-decreasing efficacy of antibiotic therapies. Frequent exposures to antibiotics favor bacterial strains that have acquired mechanisms to...
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| Veröffentlicht in: | PLoS pathogens 2020-05, Vol.16 (5), p.e1008431-e1008431 |
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| creator | Windels, Etthel M Van den Bergh, Bram Michiels, Jan |
| description | Bacteria are well known for their extremely high adaptability in stressful environments. The clinical relevance of this property is clearly illustrated by the ever-decreasing efficacy of antibiotic therapies. Frequent exposures to antibiotics favor bacterial strains that have acquired mechanisms to overcome drug inhibition and lethality. Many strains, including life-threatening pathogens, exhibit increased antibiotic resistance or tolerance, which considerably complicates clinical practice. Alarmingly, recent studies show that in addition to resistance, tolerance levels of bacterial populations are extremely flexible in an evolutionary context. Here, we summarize laboratory studies providing insight in the evolution of resistance and tolerance and shed light on how the treatment conditions could affect the direction of bacterial evolution under antibiotic stress. |
| doi_str_mv | 10.1371/journal.ppat.1008431 |
| format | Article |
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| subjects | Adaptability Adaptation Antibiotic resistance Antibiotics Bacteria Biology and Life Sciences Biotechnology Clinical medicine Computer and Information Sciences Drug dosages Drug resistance Evolution Experiments Genetics Host-bacteria relationships Laboratories Lethality Medicine and Health Sciences Mutation Observations Pathogens Pearls Population Strains (organisms) |
| title | Bacteria under antibiotic attack: Different strategies for evolutionary adaptation |
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