Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C

Lyme disease, caused by Borrelia burgdorferi, B. afzelii and B. garinii, is a chronic, multi-systemic infection and the spectrum of tissues affected can vary with the Lyme disease strain. For example, whereas B. garinii infection is associated with neurologic manifestations, B. burgdorferi infection...

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Veröffentlicht in:	PLoS pathogens 2020-05, Vol.16 (5), p.e1008516-e1008516
Hauptverfasser:	Lin, Yi-Pin, Tan, Xi, Caine, Jennifer A, Castellanos, Mildred, Chaconas, George, Coburn, Jenifer, Leong, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial Arthritis Bacterial Adhesion Bacterial Outer Membrane Proteins Binding Biochemistry Biology and Life Sciences Bladder Borrelia burgdorferi - genetics Borrelia burgdorferi - metabolism Borrelia burgdorferi - pathogenicity Chronic illnesses Chronic infection Coding Colonization Departments Dermatan Sulfate - genetics Dermatan Sulfate - metabolism Disseminated infection Extracellular matrix Extracellular Matrix - genetics Extracellular Matrix - metabolism Extracellular Matrix - microbiology Extracellular Matrix - pathology Female Fibronectin Fibronectins - genetics Fibronectins - metabolism Funding Health aspects Heparan sulfate Immunology Infections Infectious diseases Infectivity Invasiveness Joint diseases Joint Diseases - genetics Joint Diseases - metabolism Joint Diseases - microbiology Joint Diseases - pathology Joints (anatomy) Joints - metabolism Joints - microbiology Joints - pathology Lyme disease Lyme Disease - genetics Lyme Disease - metabolism Lyme Disease - microbiology Lyme Disease - pathology Medicine and Health Sciences Mice Mice, SCID Molecular biology Mutation Organ Specificity Outer surface protein C Physical Sciences Physiological aspects Protein C Proteins Research and analysis methods Spirochetes Sulfates Supervision Tissues Tropism Vector-borne diseases
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