Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection

Yersinia suppress neutrophil responses by using a type 3 secretion system (T3SS) to inject 6-7 Yersinia effector proteins (Yops) effectors into their cytoplasm. YopH is a tyrosine phosphatase that causes dephosphorylation of the adaptor protein SKAP2, among other targets in neutrophils. SKAP2 functi...

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Veröffentlicht in:	PLoS pathogens 2020-05, Vol.16 (5), p.e1008576-e1008576
Hauptverfasser:	Shaban, Lamyaa, Nguyen, Giang T, Mecsas-Faxon, Benjamin D, Swanson, Kenneth D, Tan, Shumin, Mecsas, Joan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiinfectives and antibacterials Antimicrobial agents Bacterial Outer Membrane Proteins - immunology Biology and Life Sciences Cytokines Cytoplasm Degranulation Dephosphorylation Extracellular signal-regulated kinase G protein-coupled receptors Health aspects Immunology Infections Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - immunology Leukocyte migration Leukocytes (neutrophilic) MAP Kinase Signaling System - genetics MAP Kinase Signaling System - immunology Medical research Medicine and Health Sciences Mice Mice, Inbred BALB C Mice, Knockout Molecular biology Mutants NAD(P)H oxidase Neutropenia Neutrophils Neutrophils - immunology Neutrophils - pathology Phagocytosis Phosphorylation Protein Tyrosine Phosphatases - immunology Protein-tyrosine-phosphatase Proteins Pseudotuberculosis Reactive oxygen species Reactive Oxygen Species - immunology Receptor mechanisms Receptors Signal transduction Signal Transduction - genetics Signal Transduction - immunology Signaling SLP-76 protein Syk protein Tyrosine Virulence Yersinia Yersinia pseudotuberculosis Yersinia pseudotuberculosis - immunology Yersinia pseudotuberculosis - pathogenicity Yersinia pseudotuberculosis Infections - genetics Yersinia pseudotuberculosis Infections - immunology Yersinia pseudotuberculosis Infections - pathology
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