Biophysically detailed mathematical models of multiscale cardiac active mechanics

We propose four novel mathematical models, describing the microscopic mechanisms of force generation in the cardiac muscle tissue, which are suitable for multiscale numerical simulations of cardiac electromechanics. Such models are based on a biophysically accurate representation of the regulatory a...

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Veröffentlicht in:	PLoS computational biology 2020-10, Vol.16 (10), p.e1008294-e1008294
Hauptverfasser:	Regazzoni, Francesco, Dedè, Luca, Quarteroni, Alfio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Animal models Animals Approximation Biology and Life Sciences Biophysical Phenomena - physiology Biophysics Body temperature Calcium Cardiac muscle Computational Biology Computer applications Computer simulation Electromechanics Heart - physiology Heart muscle Humans Leonardo Da Vinci (1452-1519) Male Mathematical models Mechanical properties Medicine and Health Sciences Models, Cardiovascular Monte Carlo simulation Muscle contraction Muscles Myocardium - chemistry Myocardium - cytology Myocardium - metabolism Myocytes, Cardiac - chemistry Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Myocytes, Cardiac - physiology Parameter identification Physical Sciences Physiological aspects Prolongation Proteins Rats Regulation Research and Analysis Methods Room temperature Sarcomeres Sarcomeres - chemistry Sarcomeres - metabolism Sarcomeres - physiology Simulation Temperature Young Adult
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