Nuclear plasticity increases susceptibility to damage during confined migration

Large nuclear deformations during migration through confined spaces have been associated with nuclear membrane rupture and DNA damage. However, the stresses associated with nuclear damage remain unclear. Here, using a quasi-static plane strain finite element model, we map evolution of nuclear shape...

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Veröffentlicht in:	PLoS computational biology 2020-10, Vol.16 (10), p.e1008300-e1008300
Hauptverfasser:	Mukherjee, Abhishek, Barai, Amlan, Singh, Ramesh K, Yan, Wenyi, Sen, Shamik
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerospace engineering Bioengineering Biology and Life Sciences Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement - physiology Cell Nucleus - physiology Confined spaces Cytoskeleton Damage Deformation Deoxyribonucleic acid DNA DNA Damage Fibrosarcoma Finite Element Analysis Finite element method Formability Health aspects Humans Invasiveness Kinking Mathematical models Mechanical engineering Mechanical properties Membranes Models, Biological Nuclear Envelope - physiology Nuclei (cytology) Physical properties Physical Sciences Plane strain Plastic deformation Plasticity Plastics Softening Software Stiffening Stresses Viscoelasticity
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