Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged...
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| Veröffentlicht in: | PLoS genetics 2020-10, Vol.16 (10), p.e1008718 |
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| creator | Vogelezang, Suzanne Bradfield, Jonathan P Ahluwalia, Tarunveer S Curtin, John A Lakka, Timo A Grarup, Niels Scholz, Markus van der Most, Peter J Monnereau, Claire Stergiakouli, Evie Heiskala, Anni Horikoshi, Momoko Fedko, Iryna O Vilor-Tejedor, Natalia Cousminer, Diana L Standl, Marie Wang, Carol A Viikari, Jorma Geller, Frank Íñiguez, Carmen Pitkänen, Niina Chesi, Alessandra Bacelis, Jonas Yengo, Loic Torrent, Maties Ntalla, Ioanna Helgeland, Øyvind Selzam, Saskia Vonk, Judith M Zafarmand, Mohammed H Heude, Barbara Farooqi, Ismaa Sadaf Alyass, Akram Beaumont, Robin N Have, Christian T Rzehak, Peter Bilbao, Jose Ramon Schnurr, Theresia M Barroso, Inês Bønnelykke, Klaus Beilin, Lawrence J Carstensen, Lisbeth Charles, Marie-Aline Chawes, Bo Clément, Karine Closa-Monasterolo, Ricardo Custovic, Adnan Eriksson, Johan G Escribano, Joaquin Groen-Blokhuis, Maria Grote, Veit Gruszfeld, Dariusz Hakonarson, Hakon Hansen, Torben Hattersley, Andrew T Hollensted, Mette Hottenga, Jouke-Jan Hyppönen, Elina Johansson, Stefan Joro, Raimo Kähönen, Mika Karhunen, Ville Kiess, Wieland Knight, Bridget A Koletzko, Berthold Kühnapfel, Andreas Landgraf, Kathrin Langhendries, Jean-Paul Lehtimäki, Terho Leinonen, Jaakko T Li, Aihuali Lindi, Virpi Lowry, Estelle Bustamante, Mariona Medina-Gomez, Carolina Melbye, Mads Michaelsen, Kim F Morgen, Camilla S Mori, Trevor A Nielsen, Tenna R H Niinikoski, Harri Oldehinkel, Albertine J Pahkala, Katja Panoutsopoulou, Kalliope Pedersen, Oluf Pennell, Craig E Power, Christine Reijneveld, Sijmen A Rivadeneira, Fernando Simpson, Angela Sly, Peter D Stokholm, Jakob Teo, Kook K Thiering, Elisabeth Timpson, Nicholas J Uitterlinden, André G van Beijsterveldt, Catharina E M van Schaik, Barbera D C Vaudel, Marc Verduci, Elvira |
| description | The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values |
| doi_str_mv | 10.1371/journal.pgen.1008718 |
| format | Article |
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Bradfield, Jonathan P ; Ahluwalia, Tarunveer S ; Curtin, John A ; Lakka, Timo A ; Grarup, Niels ; Scholz, Markus ; van der Most, Peter J ; Monnereau, Claire ; Stergiakouli, Evie ; Heiskala, Anni ; Horikoshi, Momoko ; Fedko, Iryna O ; Vilor-Tejedor, Natalia ; Cousminer, Diana L ; Standl, Marie ; Wang, Carol A ; Viikari, Jorma ; Geller, Frank ; Íñiguez, Carmen ; Pitkänen, Niina ; Chesi, Alessandra ; Bacelis, Jonas ; Yengo, Loic ; Torrent, Maties ; Ntalla, Ioanna ; Helgeland, Øyvind ; Selzam, Saskia ; Vonk, Judith M ; Zafarmand, Mohammed H ; Heude, Barbara ; Farooqi, Ismaa Sadaf ; Alyass, Akram ; Beaumont, Robin N ; Have, Christian T ; Rzehak, Peter ; Bilbao, Jose Ramon ; Schnurr, Theresia M ; Barroso, Inês ; Bønnelykke, Klaus ; Beilin, Lawrence J ; Carstensen, Lisbeth ; Charles, Marie-Aline ; Chawes, Bo ; Clément, Karine ; Closa-Monasterolo, Ricardo ; Custovic, Adnan ; Eriksson, Johan G ; Escribano, Joaquin ; Groen-Blokhuis, Maria ; Grote, Veit ; Gruszfeld, Dariusz ; Hakonarson, Hakon ; Hansen, Torben ; Hattersley, Andrew T ; Hollensted, Mette ; Hottenga, Jouke-Jan ; Hyppönen, Elina ; Johansson, Stefan ; Joro, Raimo ; Kähönen, Mika ; Karhunen, Ville ; Kiess, Wieland ; Knight, Bridget A ; Koletzko, Berthold ; Kühnapfel, Andreas ; Landgraf, Kathrin ; Langhendries, Jean-Paul ; Lehtimäki, Terho ; Leinonen, Jaakko T ; Li, Aihuali ; Lindi, Virpi ; Lowry, Estelle ; Bustamante, Mariona ; Medina-Gomez, Carolina ; Melbye, Mads ; Michaelsen, Kim F ; Morgen, Camilla S ; Mori, Trevor A ; Nielsen, Tenna R H ; Niinikoski, Harri ; Oldehinkel, Albertine J ; Pahkala, Katja ; Panoutsopoulou, Kalliope ; Pedersen, Oluf ; Pennell, Craig E ; Power, Christine ; Reijneveld, Sijmen A ; Rivadeneira, Fernando ; Simpson, Angela ; Sly, Peter D ; Stokholm, Jakob ; Teo, Kook K ; Thiering, Elisabeth ; Timpson, Nicholas J ; Uitterlinden, André G ; van Beijsterveldt, Catharina E M ; van Schaik, Barbera D C ; Vaudel, Marc ; Verduci, Elvira</creator><contributor>Copenhaver, Gregory P.</contributor><creatorcontrib>Vogelezang, Suzanne ; Bradfield, Jonathan P ; Ahluwalia, Tarunveer S ; Curtin, John A ; Lakka, Timo A ; Grarup, Niels ; Scholz, Markus ; van der Most, Peter J ; Monnereau, Claire ; Stergiakouli, Evie ; Heiskala, Anni ; Horikoshi, Momoko ; Fedko, Iryna O ; Vilor-Tejedor, Natalia ; Cousminer, Diana L ; Standl, Marie ; Wang, Carol A ; Viikari, Jorma ; Geller, Frank ; Íñiguez, Carmen ; Pitkänen, Niina ; Chesi, Alessandra ; Bacelis, Jonas ; Yengo, Loic ; Torrent, Maties ; Ntalla, Ioanna ; Helgeland, Øyvind ; Selzam, Saskia ; Vonk, Judith M ; Zafarmand, Mohammed H ; Heude, Barbara ; Farooqi, Ismaa Sadaf ; Alyass, Akram ; Beaumont, Robin N ; Have, Christian T ; Rzehak, Peter ; Bilbao, Jose Ramon ; Schnurr, Theresia M ; Barroso, Inês ; Bønnelykke, Klaus ; Beilin, Lawrence J ; Carstensen, Lisbeth ; Charles, Marie-Aline ; Chawes, Bo ; Clément, Karine ; Closa-Monasterolo, Ricardo ; Custovic, Adnan ; Eriksson, Johan G ; Escribano, Joaquin ; Groen-Blokhuis, Maria ; Grote, Veit ; Gruszfeld, Dariusz ; Hakonarson, Hakon ; Hansen, Torben ; Hattersley, Andrew T ; Hollensted, Mette ; Hottenga, Jouke-Jan ; Hyppönen, Elina ; Johansson, Stefan ; Joro, Raimo ; Kähönen, Mika ; Karhunen, Ville ; Kiess, Wieland ; Knight, Bridget A ; Koletzko, Berthold ; Kühnapfel, Andreas ; Landgraf, Kathrin ; Langhendries, Jean-Paul ; Lehtimäki, Terho ; Leinonen, Jaakko T ; Li, Aihuali ; Lindi, Virpi ; Lowry, Estelle ; Bustamante, Mariona ; Medina-Gomez, Carolina ; Melbye, Mads ; Michaelsen, Kim F ; Morgen, Camilla S ; Mori, Trevor A ; Nielsen, Tenna R H ; Niinikoski, Harri ; Oldehinkel, Albertine J ; Pahkala, Katja ; Panoutsopoulou, Kalliope ; Pedersen, Oluf ; Pennell, Craig E ; Power, Christine ; Reijneveld, Sijmen A ; Rivadeneira, Fernando ; Simpson, Angela ; Sly, Peter D ; Stokholm, Jakob ; Teo, Kook K ; Thiering, Elisabeth ; Timpson, Nicholas J ; Uitterlinden, André G ; van Beijsterveldt, Catharina E M ; van Schaik, Barbera D C ; Vaudel, Marc ; Verduci, Elvira ; Early Growth Genetics Consortium ; Early Growth Genetics Consortium ; Copenhaver, Gregory P.</creatorcontrib><description>The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.1008718</identifier><identifier>PMID: 33045005</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Analysis ; Asthma ; Bioinformatics ; Biology and Life Sciences ; Birth weight ; Blood Pressure ; Body Mass Index ; Cardiometabolic Risk Factors ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - pathology ; Child ; Child, Preschool ; Childhood ; Children ; Comparative analysis ; Demographic aspects ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - pathology ; Diagnosis ; Environmental health ; Epidemiology ; Female ; Funding ; Genetic factors ; Genetic Predisposition to Disease ; Genetics ; Genome-wide association studies ; Genome-Wide Association Study - methods ; Genomes ; Gynecology ; Heritability ; Hospitals ; Humans ; Life Sciences ; Male ; Medical research ; Medicine ; Medicine and Health Sciences ; Menarche ; Menarche - genetics ; Mendelian Randomization Analysis ; Metabolic diseases ; Metabolic disorders ; Metabolism ; Monosaccharide Transport Proteins - genetics ; Nedd4 Ubiquitin Protein Ligases - genetics ; Obstetrics ; Obstetrics, Gynecology and Reproductive Medicine ; Pediatrics ; Physical Sciences ; Physiology ; Public health ; Quantitative trait loci ; Reproduktionsmedicin och gynekologi ; Research and Analysis Methods ; Waist-Hip Ratio</subject><ispartof>PLoS genetics, 2020-10, Vol.16 (10), p.e1008718</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Vogelezang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Suzanne</creatorcontrib><creatorcontrib>Bradfield, Jonathan P</creatorcontrib><creatorcontrib>Ahluwalia, Tarunveer S</creatorcontrib><creatorcontrib>Curtin, John A</creatorcontrib><creatorcontrib>Lakka, Timo A</creatorcontrib><creatorcontrib>Grarup, Niels</creatorcontrib><creatorcontrib>Scholz, Markus</creatorcontrib><creatorcontrib>van der Most, Peter J</creatorcontrib><creatorcontrib>Monnereau, Claire</creatorcontrib><creatorcontrib>Stergiakouli, Evie</creatorcontrib><creatorcontrib>Heiskala, Anni</creatorcontrib><creatorcontrib>Horikoshi, Momoko</creatorcontrib><creatorcontrib>Fedko, Iryna O</creatorcontrib><creatorcontrib>Vilor-Tejedor, Natalia</creatorcontrib><creatorcontrib>Cousminer, Diana L</creatorcontrib><creatorcontrib>Standl, Marie</creatorcontrib><creatorcontrib>Wang, Carol A</creatorcontrib><creatorcontrib>Viikari, Jorma</creatorcontrib><creatorcontrib>Geller, Frank</creatorcontrib><creatorcontrib>Íñiguez, Carmen</creatorcontrib><creatorcontrib>Pitkänen, 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J</creatorcontrib><creatorcontrib>Carstensen, Lisbeth</creatorcontrib><creatorcontrib>Charles, Marie-Aline</creatorcontrib><creatorcontrib>Chawes, Bo</creatorcontrib><creatorcontrib>Clément, Karine</creatorcontrib><creatorcontrib>Closa-Monasterolo, Ricardo</creatorcontrib><creatorcontrib>Custovic, Adnan</creatorcontrib><creatorcontrib>Eriksson, Johan G</creatorcontrib><creatorcontrib>Escribano, Joaquin</creatorcontrib><creatorcontrib>Groen-Blokhuis, Maria</creatorcontrib><creatorcontrib>Grote, Veit</creatorcontrib><creatorcontrib>Gruszfeld, Dariusz</creatorcontrib><creatorcontrib>Hakonarson, Hakon</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><creatorcontrib>Hattersley, Andrew T</creatorcontrib><creatorcontrib>Hollensted, Mette</creatorcontrib><creatorcontrib>Hottenga, Jouke-Jan</creatorcontrib><creatorcontrib>Hyppönen, Elina</creatorcontrib><creatorcontrib>Johansson, Stefan</creatorcontrib><creatorcontrib>Joro, Raimo</creatorcontrib><creatorcontrib>Kähönen, Mika</creatorcontrib><creatorcontrib>Karhunen, Ville</creatorcontrib><creatorcontrib>Kiess, Wieland</creatorcontrib><creatorcontrib>Knight, Bridget A</creatorcontrib><creatorcontrib>Koletzko, Berthold</creatorcontrib><creatorcontrib>Kühnapfel, Andreas</creatorcontrib><creatorcontrib>Landgraf, Kathrin</creatorcontrib><creatorcontrib>Langhendries, Jean-Paul</creatorcontrib><creatorcontrib>Lehtimäki, Terho</creatorcontrib><creatorcontrib>Leinonen, Jaakko T</creatorcontrib><creatorcontrib>Li, Aihuali</creatorcontrib><creatorcontrib>Lindi, Virpi</creatorcontrib><creatorcontrib>Lowry, Estelle</creatorcontrib><creatorcontrib>Bustamante, Mariona</creatorcontrib><creatorcontrib>Medina-Gomez, Carolina</creatorcontrib><creatorcontrib>Melbye, Mads</creatorcontrib><creatorcontrib>Michaelsen, Kim F</creatorcontrib><creatorcontrib>Morgen, Camilla S</creatorcontrib><creatorcontrib>Mori, Trevor A</creatorcontrib><creatorcontrib>Nielsen, Tenna R H</creatorcontrib><creatorcontrib>Niinikoski, Harri</creatorcontrib><creatorcontrib>Oldehinkel, Albertine J</creatorcontrib><creatorcontrib>Pahkala, Katja</creatorcontrib><creatorcontrib>Panoutsopoulou, Kalliope</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><creatorcontrib>Pennell, Craig E</creatorcontrib><creatorcontrib>Power, Christine</creatorcontrib><creatorcontrib>Reijneveld, Sijmen A</creatorcontrib><creatorcontrib>Rivadeneira, Fernando</creatorcontrib><creatorcontrib>Simpson, Angela</creatorcontrib><creatorcontrib>Sly, Peter D</creatorcontrib><creatorcontrib>Stokholm, Jakob</creatorcontrib><creatorcontrib>Teo, Kook K</creatorcontrib><creatorcontrib>Thiering, Elisabeth</creatorcontrib><creatorcontrib>Timpson, Nicholas J</creatorcontrib><creatorcontrib>Uitterlinden, André G</creatorcontrib><creatorcontrib>van Beijsterveldt, Catharina E M</creatorcontrib><creatorcontrib>van Schaik, Barbera D C</creatorcontrib><creatorcontrib>Vaudel, Marc</creatorcontrib><creatorcontrib>Verduci, Elvira</creatorcontrib><creatorcontrib>Early Growth Genetics Consortium</creatorcontrib><creatorcontrib>Early Growth Genetics Consortium</creatorcontrib><title>Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits</title><title>PLoS genetics</title><addtitle>PLoS Genet</addtitle><description>The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Asthma</subject><subject>Bioinformatics</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cardiometabolic Risk Factors</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Comparative analysis</subject><subject>Demographic aspects</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diagnosis</subject><subject>Environmental health</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Funding</subject><subject>Genetic factors</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Genome-wide association studies</subject><subject>Genome-Wide Association Study - methods</subject><subject>Genomes</subject><subject>Gynecology</subject><subject>Heritability</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Menarche</subject><subject>Menarche - genetics</subject><subject>Mendelian Randomization Analysis</subject><subject>Metabolic diseases</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Monosaccharide Transport Proteins - genetics</subject><subject>Nedd4 Ubiquitin Protein Ligases - genetics</subject><subject>Obstetrics</subject><subject>Obstetrics, Gynecology and Reproductive Medicine</subject><subject>Pediatrics</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Public health</subject><subject>Quantitative trait loci</subject><subject>Reproduktionsmedicin och gynekologi</subject><subject>Research and Analysis Methods</subject><subject>Waist-Hip 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loci for childhood body mass index and shared heritability with adult cardiometabolic traits</title><author>Vogelezang, Suzanne ; Bradfield, Jonathan P ; Ahluwalia, Tarunveer S ; Curtin, John A ; Lakka, Timo A ; Grarup, Niels ; Scholz, Markus ; van der Most, Peter J ; Monnereau, Claire ; Stergiakouli, Evie ; Heiskala, Anni ; Horikoshi, Momoko ; Fedko, Iryna O ; Vilor-Tejedor, Natalia ; Cousminer, Diana L ; Standl, Marie ; Wang, Carol A ; Viikari, Jorma ; Geller, Frank ; Íñiguez, Carmen ; Pitkänen, Niina ; Chesi, Alessandra ; Bacelis, Jonas ; Yengo, Loic ; Torrent, Maties ; Ntalla, Ioanna ; Helgeland, Øyvind ; Selzam, Saskia ; Vonk, Judith M ; Zafarmand, Mohammed H ; Heude, Barbara ; Farooqi, Ismaa Sadaf ; Alyass, Akram ; Beaumont, Robin N ; Have, Christian T ; Rzehak, Peter ; Bilbao, Jose Ramon ; Schnurr, Theresia M ; Barroso, Inês ; Bønnelykke, Klaus ; Beilin, Lawrence J ; Carstensen, Lisbeth ; Charles, Marie-Aline ; Chawes, Bo ; Clément, Karine ; Closa-Monasterolo, Ricardo ; Custovic, Adnan ; Eriksson, Johan G ; Escribano, Joaquin ; Groen-Blokhuis, Maria ; Grote, Veit ; Gruszfeld, Dariusz ; Hakonarson, Hakon ; Hansen, Torben ; Hattersley, Andrew T ; Hollensted, Mette ; Hottenga, Jouke-Jan ; Hyppönen, Elina ; Johansson, Stefan ; Joro, Raimo ; Kähönen, Mika ; Karhunen, Ville ; Kiess, Wieland ; Knight, Bridget A ; Koletzko, Berthold ; Kühnapfel, Andreas ; Landgraf, Kathrin ; Langhendries, Jean-Paul ; Lehtimäki, Terho ; Leinonen, Jaakko T ; Li, Aihuali ; Lindi, Virpi ; Lowry, Estelle ; Bustamante, Mariona ; Medina-Gomez, Carolina ; Melbye, Mads ; Michaelsen, Kim F ; Morgen, Camilla S ; Mori, Trevor A ; Nielsen, Tenna R H ; Niinikoski, Harri ; Oldehinkel, Albertine J ; Pahkala, Katja ; Panoutsopoulou, Kalliope ; Pedersen, Oluf ; Pennell, Craig E ; Power, Christine ; Reijneveld, Sijmen A ; Rivadeneira, Fernando ; Simpson, Angela ; Sly, Peter D ; Stokholm, Jakob ; Teo, Kook K ; Thiering, Elisabeth ; Timpson, Nicholas J ; Uitterlinden, André G ; van Beijsterveldt, Catharina E M ; van Schaik, Barbera D C ; Vaudel, Marc ; Verduci, Elvira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c798t-dbb9c8efe53251e8cd700db036b3ceea7781ae20fc2b0e96495886b2f3af9f973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Asthma</topic><topic>Bioinformatics</topic><topic>Biology and Life Sciences</topic><topic>Birth weight</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cardiometabolic Risk Factors</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cardiovascular Diseases - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Comparative analysis</topic><topic>Demographic aspects</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Diagnosis</topic><topic>Environmental health</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Funding</topic><topic>Genetic factors</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Genome-wide association studies</topic><topic>Genome-Wide Association Study - methods</topic><topic>Genomes</topic><topic>Gynecology</topic><topic>Heritability</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Menarche</topic><topic>Menarche - genetics</topic><topic>Mendelian Randomization Analysis</topic><topic>Metabolic diseases</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>Monosaccharide Transport Proteins - genetics</topic><topic>Nedd4 Ubiquitin Protein Ligases - genetics</topic><topic>Obstetrics</topic><topic>Obstetrics, Gynecology and Reproductive Medicine</topic><topic>Pediatrics</topic><topic>Physical Sciences</topic><topic>Physiology</topic><topic>Public health</topic><topic>Quantitative trait loci</topic><topic>Reproduktionsmedicin och gynekologi</topic><topic>Research and Analysis Methods</topic><topic>Waist-Hip Ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vogelezang, Suzanne</creatorcontrib><creatorcontrib>Bradfield, Jonathan P</creatorcontrib><creatorcontrib>Ahluwalia, Tarunveer S</creatorcontrib><creatorcontrib>Curtin, John A</creatorcontrib><creatorcontrib>Lakka, Timo A</creatorcontrib><creatorcontrib>Grarup, Niels</creatorcontrib><creatorcontrib>Scholz, Markus</creatorcontrib><creatorcontrib>van der Most, Peter J</creatorcontrib><creatorcontrib>Monnereau, Claire</creatorcontrib><creatorcontrib>Stergiakouli, Evie</creatorcontrib><creatorcontrib>Heiskala, 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P</au><au>Ahluwalia, Tarunveer S</au><au>Curtin, John A</au><au>Lakka, Timo A</au><au>Grarup, Niels</au><au>Scholz, Markus</au><au>van der Most, Peter J</au><au>Monnereau, Claire</au><au>Stergiakouli, Evie</au><au>Heiskala, Anni</au><au>Horikoshi, Momoko</au><au>Fedko, Iryna O</au><au>Vilor-Tejedor, Natalia</au><au>Cousminer, Diana L</au><au>Standl, Marie</au><au>Wang, Carol A</au><au>Viikari, Jorma</au><au>Geller, Frank</au><au>Íñiguez, Carmen</au><au>Pitkänen, Niina</au><au>Chesi, Alessandra</au><au>Bacelis, Jonas</au><au>Yengo, Loic</au><au>Torrent, Maties</au><au>Ntalla, Ioanna</au><au>Helgeland, Øyvind</au><au>Selzam, Saskia</au><au>Vonk, Judith M</au><au>Zafarmand, Mohammed H</au><au>Heude, Barbara</au><au>Farooqi, Ismaa Sadaf</au><au>Alyass, Akram</au><au>Beaumont, Robin N</au><au>Have, Christian T</au><au>Rzehak, Peter</au><au>Bilbao, Jose Ramon</au><au>Schnurr, Theresia M</au><au>Barroso, Inês</au><au>Bønnelykke, Klaus</au><au>Beilin, Lawrence J</au><au>Carstensen, Lisbeth</au><au>Charles, Marie-Aline</au><au>Chawes, Bo</au><au>Clément, Karine</au><au>Closa-Monasterolo, Ricardo</au><au>Custovic, Adnan</au><au>Eriksson, Johan G</au><au>Escribano, Joaquin</au><au>Groen-Blokhuis, Maria</au><au>Grote, Veit</au><au>Gruszfeld, Dariusz</au><au>Hakonarson, Hakon</au><au>Hansen, Torben</au><au>Hattersley, Andrew T</au><au>Hollensted, Mette</au><au>Hottenga, Jouke-Jan</au><au>Hyppönen, Elina</au><au>Johansson, Stefan</au><au>Joro, Raimo</au><au>Kähönen, Mika</au><au>Karhunen, Ville</au><au>Kiess, Wieland</au><au>Knight, Bridget A</au><au>Koletzko, Berthold</au><au>Kühnapfel, Andreas</au><au>Landgraf, Kathrin</au><au>Langhendries, Jean-Paul</au><au>Lehtimäki, Terho</au><au>Leinonen, Jaakko T</au><au>Li, Aihuali</au><au>Lindi, Virpi</au><au>Lowry, Estelle</au><au>Bustamante, Mariona</au><au>Medina-Gomez, Carolina</au><au>Melbye, Mads</au><au>Michaelsen, Kim F</au><au>Morgen, Camilla S</au><au>Mori, Trevor A</au><au>Nielsen, Tenna R H</au><au>Niinikoski, Harri</au><au>Oldehinkel, Albertine J</au><au>Pahkala, Katja</au><au>Panoutsopoulou, Kalliope</au><au>Pedersen, Oluf</au><au>Pennell, Craig E</au><au>Power, Christine</au><au>Reijneveld, Sijmen A</au><au>Rivadeneira, Fernando</au><au>Simpson, Angela</au><au>Sly, Peter D</au><au>Stokholm, Jakob</au><au>Teo, Kook K</au><au>Thiering, Elisabeth</au><au>Timpson, Nicholas J</au><au>Uitterlinden, André G</au><au>van Beijsterveldt, Catharina E M</au><au>van Schaik, Barbera D C</au><au>Vaudel, Marc</au><au>Verduci, Elvira</au><au>Copenhaver, Gregory P.</au><aucorp>Early Growth Genetics Consortium</aucorp><aucorp>Early Growth Genetics Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits</atitle><jtitle>PLoS genetics</jtitle><addtitle>PLoS Genet</addtitle><date>2020-10-12</date><risdate>2020</risdate><volume>16</volume><issue>10</issue><spage>e1008718</spage><pages>e1008718-</pages><issn>1553-7404</issn><issn>1553-7390</issn><eissn>1553-7404</eissn><abstract>The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33045005</pmid><doi>10.1371/journal.pgen.1008718</doi><orcidid>https://orcid.org/0000-0003-4850-7444</orcidid><orcidid>https://orcid.org/0000-0002-2414-4928</orcidid><orcidid>https://orcid.org/0000-0002-2489-3355</orcidid><orcidid>https://orcid.org/0000-0001-7168-2385</orcidid><orcidid>https://orcid.org/0000-0002-4510-7341</orcidid><orcidid>https://orcid.org/0000-0001-5079-2374</orcidid><orcidid>https://orcid.org/0000-0003-4619-6785</orcidid><orcidid>https://orcid.org/0000-0002-7090-1758</orcidid><orcidid>https://orcid.org/0000-0002-3321-3972</orcidid><orcidid>https://orcid.org/0000-0003-2111-3111</orcidid><orcidid>https://orcid.org/0000-0003-0127-2860</orcidid><orcidid>https://orcid.org/0000-0002-5345-2049</orcidid><orcidid>https://orcid.org/0000-0001-8748-3831</orcidid><orcidid>https://orcid.org/0000-0002-9801-5774</orcidid><orcidid>https://orcid.org/0000-0002-1565-1629</orcidid><orcidid>https://orcid.org/0000-0003-4025-4390</orcidid><orcidid>https://orcid.org/0000-0002-7798-6221</orcidid><orcidid>https://orcid.org/0000-0003-2814-7461</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1553-7404 |
| ispartof | PLoS genetics, 2020-10, Vol.16 (10), p.e1008718 |
| issn | 1553-7404 1553-7390 1553-7404 |
| language | eng |
| recordid | cdi_plos_journals_2460112751 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adolescent Adult Analysis Asthma Bioinformatics Biology and Life Sciences Birth weight Blood Pressure Body Mass Index Cardiometabolic Risk Factors Cardiovascular Diseases - genetics Cardiovascular Diseases - pathology Child Child, Preschool Childhood Children Comparative analysis Demographic aspects Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Diagnosis Environmental health Epidemiology Female Funding Genetic factors Genetic Predisposition to Disease Genetics Genome-wide association studies Genome-Wide Association Study - methods Genomes Gynecology Heritability Hospitals Humans Life Sciences Male Medical research Medicine Medicine and Health Sciences Menarche Menarche - genetics Mendelian Randomization Analysis Metabolic diseases Metabolic disorders Metabolism Monosaccharide Transport Proteins - genetics Nedd4 Ubiquitin Protein Ligases - genetics Obstetrics Obstetrics, Gynecology and Reproductive Medicine Pediatrics Physical Sciences Physiology Public health Quantitative trait loci Reproduktionsmedicin och gynekologi Research and Analysis Methods Waist-Hip Ratio |
| title | Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits |
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