Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for "polygenic epistasis"

The majority of quantitative genetic models used to map complex traits assume that alleles have similar effects across all individuals. Significant evidence suggests, however, that epistatic interactions modulate the impact of many alleles. Nevertheless, identifying epistatic interactions remains co...

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Veröffentlicht in:	PLoS genetics 2020-10, Vol.16 (10), p.e1009165-e1009165
Hauptverfasser:	Rau, Christoph D, Gonzales, Natalia M, Bloom, Joshua S, Park, Danny, Ayroles, Julien, Palmer, Abraham A, Lusis, Aldons J, Zaitlen, Noah
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biology and Life Sciences Divergence Epistasis Epistasis, Genetic Evolution, Molecular Gene expression Genealogy Genetic aspects Genetic epistasis Genetics Genomes Genotype Humans Methods Mice Models, Genetic Multifactorial Inheritance - genetics Organisms Phenotype Phenotypes Polygenic inheritance Polymorphism Population Quantitative Trait Loci - genetics Random variables Research and Analysis Methods Saccharomyces cerevisiae - genetics Selection, Genetic - genetics Single-nucleotide polymorphism Yeast Yeast fungi
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