Sex-based differences and aging in tactile function loss in persons with type 2 diabetes
Recent evidence of significant sex-based differences in the presentation of Type 2 Diabetes Mellitus (DM) and its complications has been found in humans, which may contribute to sex-based differences in reduced functionality and quality of life. Some functionality, such as tactile function of the ha...
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| creator | Gorniak, Stacey L Ochoa, Nereyda Cox, Lauren I Gulley Khan, Aisha Ansari, Sahifah Thames, Beatriz Ray, Haley Lu, Yoshimi F Hibino, Hidetaka Watson, Nikita Dougherty, Patrick M |
| description | Recent evidence of significant sex-based differences in the presentation of Type 2 Diabetes Mellitus (DM) and its complications has been found in humans, which may contribute to sex-based differences in reduced functionality and quality of life. Some functionality, such as tactile function of the hands, has significant direct impact on quality of life. The purpose of the current study was to explore the impact of DM and sex on tactile function, with consideration of variability in health state measures.
A case-control single time point observational study from 2012-2020 in an ethnically diverse population-based community setting. The sample consists of 132 adult individuals: 70 independent community dwelling persons with DM (PwDM) and 62 age- and sex-matched controls (42 males and 90 females in total). The Semmes-Weinstein monofilament test was used to evaluate tactile sensation of the hands.
Tactile sensation thresholds were adversely impacted by sex, age, degree of handedness, high A1c, diagnosis of DM, and neuropathy. Overall, strongly right-handed older adult males with poorly controlled DM and neuropathy possessed the poorest tactile discrimination thresholds. When self-identified minority status was included in a secondary analysis, DM diagnosis was no longer significant; negative impacts of age, neuropathy, degree of handedness, and high A1c remained significant.
The data indicate significant impacts of male sex, age, degree of handedness, self-identified minority status, and metabolic health on the development of poor tactile sensation. This combination of modifiable and non-modifiable factors are important considerations in the monitoring and treatment of DM complications. |
| doi_str_mv | 10.1371/journal.pone.0242199 |
| format | Article |
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A case-control single time point observational study from 2012-2020 in an ethnically diverse population-based community setting. The sample consists of 132 adult individuals: 70 independent community dwelling persons with DM (PwDM) and 62 age- and sex-matched controls (42 males and 90 females in total). The Semmes-Weinstein monofilament test was used to evaluate tactile sensation of the hands.
Tactile sensation thresholds were adversely impacted by sex, age, degree of handedness, high A1c, diagnosis of DM, and neuropathy. Overall, strongly right-handed older adult males with poorly controlled DM and neuropathy possessed the poorest tactile discrimination thresholds. When self-identified minority status was included in a secondary analysis, DM diagnosis was no longer significant; negative impacts of age, neuropathy, degree of handedness, and high A1c remained significant.
The data indicate significant impacts of male sex, age, degree of handedness, self-identified minority status, and metabolic health on the development of poor tactile sensation. This combination of modifiable and non-modifiable factors are important considerations in the monitoring and treatment of DM complications.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0242199</identifier><identifier>PMID: 33180801</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Aging ; Aging - physiology ; Biology and Life Sciences ; Blood pressure ; Care and treatment ; Case-Control Studies ; Complications ; Complications and side effects ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic neuropathy ; Diagnosis ; Disease age factors ; Disease sex factors ; Female ; Females ; Glucose ; Handedness ; Hemoglobin ; Human performance ; Humans ; Male ; Males ; Medicine and Health Sciences ; Metabolism ; Middle Aged ; Neuropathy ; Observational studies ; Observations ; Older people ; Peripheral neuropathy ; Quality of life ; Research design ; Risk factors ; Secondary analysis ; Sensory disorders ; Sensory Thresholds ; Sex ; Sex Factors ; Sexes ; Social Sciences ; Tactile discrimination ; Testosterone ; Thresholds ; Touch ; Touch Perception ; Type 2 diabetes</subject><ispartof>PloS one, 2020-11, Vol.15 (11), p.e0242199-e0242199</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Gorniak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Gorniak et al 2020 Gorniak et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e7bd2b512c56a29cee3b4cfb36139881dd4a78af1a8547ddfb7c7fb5b847bad3</citedby><cites>FETCH-LOGICAL-c692t-e7bd2b512c56a29cee3b4cfb36139881dd4a78af1a8547ddfb7c7fb5b847bad3</cites><orcidid>0000-0002-8192-850X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660517/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660517/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33180801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorniak, Stacey L</creatorcontrib><creatorcontrib>Ochoa, Nereyda</creatorcontrib><creatorcontrib>Cox, Lauren I Gulley</creatorcontrib><creatorcontrib>Khan, Aisha</creatorcontrib><creatorcontrib>Ansari, Sahifah</creatorcontrib><creatorcontrib>Thames, Beatriz</creatorcontrib><creatorcontrib>Ray, Haley</creatorcontrib><creatorcontrib>Lu, Yoshimi F</creatorcontrib><creatorcontrib>Hibino, Hidetaka</creatorcontrib><creatorcontrib>Watson, Nikita</creatorcontrib><creatorcontrib>Dougherty, Patrick M</creatorcontrib><title>Sex-based differences and aging in tactile function loss in persons with type 2 diabetes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Recent evidence of significant sex-based differences in the presentation of Type 2 Diabetes Mellitus (DM) and its complications has been found in humans, which may contribute to sex-based differences in reduced functionality and quality of life. Some functionality, such as tactile function of the hands, has significant direct impact on quality of life. The purpose of the current study was to explore the impact of DM and sex on tactile function, with consideration of variability in health state measures.
A case-control single time point observational study from 2012-2020 in an ethnically diverse population-based community setting. The sample consists of 132 adult individuals: 70 independent community dwelling persons with DM (PwDM) and 62 age- and sex-matched controls (42 males and 90 females in total). The Semmes-Weinstein monofilament test was used to evaluate tactile sensation of the hands.
Tactile sensation thresholds were adversely impacted by sex, age, degree of handedness, high A1c, diagnosis of DM, and neuropathy. Overall, strongly right-handed older adult males with poorly controlled DM and neuropathy possessed the poorest tactile discrimination thresholds. When self-identified minority status was included in a secondary analysis, DM diagnosis was no longer significant; negative impacts of age, neuropathy, degree of handedness, and high A1c remained significant.
The data indicate significant impacts of male sex, age, degree of handedness, self-identified minority status, and metabolic health on the development of poor tactile sensation. This combination of modifiable and non-modifiable factors are important considerations in the monitoring and treatment of DM complications.</description><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic neuropathy</subject><subject>Diagnosis</subject><subject>Disease age factors</subject><subject>Disease sex factors</subject><subject>Female</subject><subject>Females</subject><subject>Glucose</subject><subject>Handedness</subject><subject>Hemoglobin</subject><subject>Human performance</subject><subject>Humans</subject><subject>Male</subject><subject>Males</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Neuropathy</subject><subject>Observational studies</subject><subject>Observations</subject><subject>Older people</subject><subject>Peripheral neuropathy</subject><subject>Quality of life</subject><subject>Research design</subject><subject>Risk factors</subject><subject>Secondary analysis</subject><subject>Sensory disorders</subject><subject>Sensory Thresholds</subject><subject>Sex</subject><subject>Sex Factors</subject><subject>Sexes</subject><subject>Social Sciences</subject><subject>Tactile discrimination</subject><subject>Testosterone</subject><subject>Thresholds</subject><subject>Touch</subject><subject>Touch Perception</subject><subject>Type 2 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Nikita</au><au>Dougherty, Patrick M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-based differences and aging in tactile function loss in persons with type 2 diabetes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-11-12</date><risdate>2020</risdate><volume>15</volume><issue>11</issue><spage>e0242199</spage><epage>e0242199</epage><pages>e0242199-e0242199</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Recent evidence of significant sex-based differences in the presentation of Type 2 Diabetes Mellitus (DM) and its complications has been found in humans, which may contribute to sex-based differences in reduced functionality and quality of life. Some functionality, such as tactile function of the hands, has significant direct impact on quality of life. The purpose of the current study was to explore the impact of DM and sex on tactile function, with consideration of variability in health state measures.
A case-control single time point observational study from 2012-2020 in an ethnically diverse population-based community setting. The sample consists of 132 adult individuals: 70 independent community dwelling persons with DM (PwDM) and 62 age- and sex-matched controls (42 males and 90 females in total). The Semmes-Weinstein monofilament test was used to evaluate tactile sensation of the hands.
Tactile sensation thresholds were adversely impacted by sex, age, degree of handedness, high A1c, diagnosis of DM, and neuropathy. Overall, strongly right-handed older adult males with poorly controlled DM and neuropathy possessed the poorest tactile discrimination thresholds. When self-identified minority status was included in a secondary analysis, DM diagnosis was no longer significant; negative impacts of age, neuropathy, degree of handedness, and high A1c remained significant.
The data indicate significant impacts of male sex, age, degree of handedness, self-identified minority status, and metabolic health on the development of poor tactile sensation. This combination of modifiable and non-modifiable factors are important considerations in the monitoring and treatment of DM complications.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33180801</pmid><doi>10.1371/journal.pone.0242199</doi><tpages>e0242199</tpages><orcidid>https://orcid.org/0000-0002-8192-850X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-11, Vol.15 (11), p.e0242199-e0242199 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2460089499 |
| source | MEDLINE; Public Library of Science; PubMed Central (PMC); Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Age Aged Aging Aging - physiology Biology and Life Sciences Blood pressure Care and treatment Case-Control Studies Complications Complications and side effects Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - physiopathology Diabetic neuropathy Diagnosis Disease age factors Disease sex factors Female Females Glucose Handedness Hemoglobin Human performance Humans Male Males Medicine and Health Sciences Metabolism Middle Aged Neuropathy Observational studies Observations Older people Peripheral neuropathy Quality of life Research design Risk factors Secondary analysis Sensory disorders Sensory Thresholds Sex Sex Factors Sexes Social Sciences Tactile discrimination Testosterone Thresholds Touch Touch Perception Type 2 diabetes |
| title | Sex-based differences and aging in tactile function loss in persons with type 2 diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T15%3A27%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex-based%20differences%20and%20aging%20in%20tactile%20function%20loss%20in%20persons%20with%20type%202%20diabetes&rft.jtitle=PloS%20one&rft.au=Gorniak,%20Stacey%20L&rft.date=2020-11-12&rft.volume=15&rft.issue=11&rft.spage=e0242199&rft.epage=e0242199&rft.pages=e0242199-e0242199&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0242199&rft_dat=%3Cgale_plos_%3EA641342788%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2460089499&rft_id=info:pmid/33180801&rft_galeid=A641342788&rft_doaj_id=oai_doaj_org_article_b953f78a89e746c8bff7d399a78f9cd1&rfr_iscdi=true |