On the treatment effect heterogeneity of antidepressants in major depression: A Bayesian meta-analysis and simulation study

The average treatment effect of antidepressants in major depression was found to be about 2 points on the 17-item Hamilton Depression Rating Scale, which lies below clinical relevance. Here, we searched for evidence of a relevant treatment effect heterogeneity that could justify the usage of antidep...

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Veröffentlicht in:	PloS one 2020-11, Vol.15 (11), p.e0241497-e0241497
Hauptverfasser:	Volkmann, Constantin, Volkmann, Alexander, Müller, Christian A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressants Antidepressive Agents - therapeutic use Bayes Theorem Bayesian analysis Clinical trials Coefficient of variation Computer and Information Sciences Computer Simulation Datasets Depressive Disorder, Major - drug therapy Dosage and administration Drug therapy Engineering and Technology Heterogeneity Humans Intervention Linear Models Major depressive disorder Mathematical models Medicine and Health Sciences Mental depression Meta-analysis Normal distribution Patient outcomes Physical Sciences Psychotherapy Psychotropic drugs Regression analysis Regression models Research and Analysis Methods Standard deviation Treatment Outcome Variability
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