Novel measurement tool and model for aberrant urinary stream in 3D printed urethras derived from human tissue
An estimated 10% of male adults have split or dribbled stream leading to poor hygiene, embarrassment, and inconvenience. There is no current metric that measures male stream deviation. To develop a novel method to measure spray in normal and abnormal anatomical conformations. We developed a novel pl...
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| creator | Cohen, Andrew J Patino, German Mirramezani, Mehran Srirangapatanam, Sudarshan Tresh, Anas Cheema, Bhagat Tai, Jenny Romero, Dylan Enriquez, Anthony Baskin, Laurence S Shadden, Shawn C Breyer, Benjamin N |
| description | An estimated 10% of male adults have split or dribbled stream leading to poor hygiene, embarrassment, and inconvenience. There is no current metric that measures male stream deviation.
To develop a novel method to measure spray in normal and abnormal anatomical conformations.
We developed a novel platform to reliably describe spray. We used cadaveric tissues and 3D Printed models to study the impact of meatal shape on the urinary stream. Cadaveric penile tissue and 3D printed models were affixed to a fluid pump and used to simulate micturition. Dye captured on fabric allowed for spray detection.
Spray pattern area, deviation from normal location, and flowrates were recorded. Computational fluid dynamic models were created to study fluid vorticity.
Obstructions at the penile tip worsened spray dynamics and reduced flow. Ventral meatotomy improved flowrate (p |
| doi_str_mv | 10.1371/journal.pone.0241507 |
| format | Article |
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To develop a novel method to measure spray in normal and abnormal anatomical conformations.
We developed a novel platform to reliably describe spray. We used cadaveric tissues and 3D Printed models to study the impact of meatal shape on the urinary stream. Cadaveric penile tissue and 3D printed models were affixed to a fluid pump and used to simulate micturition. Dye captured on fabric allowed for spray detection.
Spray pattern area, deviation from normal location, and flowrates were recorded. Computational fluid dynamic models were created to study fluid vorticity.
Obstructions at the penile tip worsened spray dynamics and reduced flow. Ventral meatotomy improved flowrate (p<0.05) and reduced spray (p<0.05) compared to tips obstructed ventrally, dorsally or in the fossa navicularis. 3D models do not fully reproduce parameters of their parent cadaver material. The average flowrate from 3D model was 10ml/sec less than that of the penis from which it was derived (p = 0.03). Nonetheless, as in cadavers, increasing obstruction in 3D models leads to the same pattern of reduced flowrate and worse spray. Dynamic modeling revealed increasing distal obstruction was correlated to higher relative vorticity observed at the urethral tip.
We developed a robust method to measure urine spray in a research setting. Dynamic 3D printed models hold promise as a methodology to study common pathologies in the urethra and corrective surgeries on the urine stream that would not be feasible in patients. These novel methods require further validation, but offer promise as a research and clinical tool.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0241507</identifier><identifier>PMID: 33175862</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Artificial organs ; Biology and Life Sciences ; Cadaver ; Cadavers ; Computer applications ; Deviation ; Dynamic models ; Engineering and technology ; Experiments ; Flow (Dynamics) ; Human tissues ; Humans ; Hydrodynamics ; Hygiene ; Measurement ; Mechanical engineering ; Medical research ; Medicine and Health Sciences ; Models, Biological ; Obstructions ; Pattern analysis ; Penis ; Physical Sciences ; Physiological aspects ; Printing, Three-Dimensional ; Quality of life ; Relative vorticity ; Statistical analysis ; Surgery ; Three dimensional flow ; Three dimensional models ; Three dimensional printing ; Tissues ; Urethra ; Urethra - physiology ; Urination ; Urination - physiology ; Urine ; Urology ; Vorticity</subject><ispartof>PloS one, 2020-11, Vol.15 (11), p.e0241507</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Cohen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Cohen et al 2020 Cohen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-27ff0b9960f7bc2c314af5e38f592f3ed1e5d3b86cc47b2129763dbb202be62a3</citedby><cites>FETCH-LOGICAL-c552t-27ff0b9960f7bc2c314af5e38f592f3ed1e5d3b86cc47b2129763dbb202be62a3</cites><orcidid>0000-0002-9179-3573 ; 0000-0002-0638-4100</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657556/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657556/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33175862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, Andrew J</creatorcontrib><creatorcontrib>Patino, German</creatorcontrib><creatorcontrib>Mirramezani, Mehran</creatorcontrib><creatorcontrib>Srirangapatanam, Sudarshan</creatorcontrib><creatorcontrib>Tresh, Anas</creatorcontrib><creatorcontrib>Cheema, Bhagat</creatorcontrib><creatorcontrib>Tai, Jenny</creatorcontrib><creatorcontrib>Romero, Dylan</creatorcontrib><creatorcontrib>Enriquez, Anthony</creatorcontrib><creatorcontrib>Baskin, Laurence S</creatorcontrib><creatorcontrib>Shadden, Shawn C</creatorcontrib><creatorcontrib>Breyer, Benjamin N</creatorcontrib><title>Novel measurement tool and model for aberrant urinary stream in 3D printed urethras derived from human tissue</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>An estimated 10% of male adults have split or dribbled stream leading to poor hygiene, embarrassment, and inconvenience. There is no current metric that measures male stream deviation.
To develop a novel method to measure spray in normal and abnormal anatomical conformations.
We developed a novel platform to reliably describe spray. We used cadaveric tissues and 3D Printed models to study the impact of meatal shape on the urinary stream. Cadaveric penile tissue and 3D printed models were affixed to a fluid pump and used to simulate micturition. Dye captured on fabric allowed for spray detection.
Spray pattern area, deviation from normal location, and flowrates were recorded. Computational fluid dynamic models were created to study fluid vorticity.
Obstructions at the penile tip worsened spray dynamics and reduced flow. Ventral meatotomy improved flowrate (p<0.05) and reduced spray (p<0.05) compared to tips obstructed ventrally, dorsally or in the fossa navicularis. 3D models do not fully reproduce parameters of their parent cadaver material. The average flowrate from 3D model was 10ml/sec less than that of the penis from which it was derived (p = 0.03). Nonetheless, as in cadavers, increasing obstruction in 3D models leads to the same pattern of reduced flowrate and worse spray. Dynamic modeling revealed increasing distal obstruction was correlated to higher relative vorticity observed at the urethral tip.
We developed a robust method to measure urine spray in a research setting. Dynamic 3D printed models hold promise as a methodology to study common pathologies in the urethra and corrective surgeries on the urine stream that would not be feasible in patients. These novel methods require further validation, but offer promise as a research and clinical tool.</description><subject>Artificial organs</subject><subject>Biology and Life Sciences</subject><subject>Cadaver</subject><subject>Cadavers</subject><subject>Computer applications</subject><subject>Deviation</subject><subject>Dynamic models</subject><subject>Engineering and technology</subject><subject>Experiments</subject><subject>Flow (Dynamics)</subject><subject>Human tissues</subject><subject>Humans</subject><subject>Hydrodynamics</subject><subject>Hygiene</subject><subject>Measurement</subject><subject>Mechanical engineering</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Models, Biological</subject><subject>Obstructions</subject><subject>Pattern analysis</subject><subject>Penis</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Printing, Three-Dimensional</subject><subject>Quality of life</subject><subject>Relative vorticity</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Three dimensional flow</subject><subject>Three dimensional models</subject><subject>Three dimensional printing</subject><subject>Tissues</subject><subject>Urethra</subject><subject>Urethra - physiology</subject><subject>Urination</subject><subject>Urination - physiology</subject><subject>Urine</subject><subject>Urology</subject><subject>Vorticity</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp1Uk2LFDEQbURx19V_IBoQvM2Y73QuwrJ-LSx60XNIJ5WZHro7Y5Ie8N-bcXqXnYOnhHqvXr0qXtO8JnhNmCIfdnFOkx3W-zjBGlNOBFZPmkuiGV1JitnTR_-L5kXOO4wFa6V83lwwRpRoJb1sxu_xAAMaweY5wQhTQSXGAdnJozH6CoWYkO0gJVuxOfWTTX9QLgnsiPoJsU9oX4sFfAWhbJPNyEPqD7UQUhzRdh7thEqf8wwvm2fBDhleLe9V8-vL558331Z3P77e3lzfrZwQtKyoCgF3WkscVOeoY4TbIIC1QWgaGHgCwrOulc5x1VFCtZLMdx3FtANJLbtq3p5090PMZrlUNpQLLYkQmlXG7Ynho92ZusFY1zLR9uZfIaaNsan0bgDDnfRSt1Th1vKguBUAoqXaBeKV1sdpH5dpczeCd_WIyQ5noufI1G_NJh6MkkIJIavAu0Ugxd8z5PIfywtrY6urfgqxirmxz85cS04oZ1Txynr_iLUFO5RtjsNc-jjlcyI_EV2KOScID4YJNseE3Zswx4SZJWG17c3jZR-a7iPF_gIFqs8s</recordid><startdate>20201111</startdate><enddate>20201111</enddate><creator>Cohen, 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measurement tool and model for aberrant urinary stream in 3D printed urethras derived from human tissue</title><author>Cohen, Andrew J ; Patino, German ; Mirramezani, Mehran ; Srirangapatanam, Sudarshan ; Tresh, Anas ; Cheema, Bhagat ; Tai, Jenny ; Romero, Dylan ; Enriquez, Anthony ; Baskin, Laurence S ; Shadden, Shawn C ; Breyer, Benjamin N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-27ff0b9960f7bc2c314af5e38f592f3ed1e5d3b86cc47b2129763dbb202be62a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Artificial organs</topic><topic>Biology and Life Sciences</topic><topic>Cadaver</topic><topic>Cadavers</topic><topic>Computer applications</topic><topic>Deviation</topic><topic>Dynamic models</topic><topic>Engineering and technology</topic><topic>Experiments</topic><topic>Flow (Dynamics)</topic><topic>Human 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tissue</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-11-11</date><risdate>2020</risdate><volume>15</volume><issue>11</issue><spage>e0241507</spage><pages>e0241507-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>An estimated 10% of male adults have split or dribbled stream leading to poor hygiene, embarrassment, and inconvenience. There is no current metric that measures male stream deviation.
To develop a novel method to measure spray in normal and abnormal anatomical conformations.
We developed a novel platform to reliably describe spray. We used cadaveric tissues and 3D Printed models to study the impact of meatal shape on the urinary stream. Cadaveric penile tissue and 3D printed models were affixed to a fluid pump and used to simulate micturition. Dye captured on fabric allowed for spray detection.
Spray pattern area, deviation from normal location, and flowrates were recorded. Computational fluid dynamic models were created to study fluid vorticity.
Obstructions at the penile tip worsened spray dynamics and reduced flow. Ventral meatotomy improved flowrate (p<0.05) and reduced spray (p<0.05) compared to tips obstructed ventrally, dorsally or in the fossa navicularis. 3D models do not fully reproduce parameters of their parent cadaver material. The average flowrate from 3D model was 10ml/sec less than that of the penis from which it was derived (p = 0.03). Nonetheless, as in cadavers, increasing obstruction in 3D models leads to the same pattern of reduced flowrate and worse spray. Dynamic modeling revealed increasing distal obstruction was correlated to higher relative vorticity observed at the urethral tip.
We developed a robust method to measure urine spray in a research setting. Dynamic 3D printed models hold promise as a methodology to study common pathologies in the urethra and corrective surgeries on the urine stream that would not be feasible in patients. These novel methods require further validation, but offer promise as a research and clinical tool.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33175862</pmid><doi>10.1371/journal.pone.0241507</doi><orcidid>https://orcid.org/0000-0002-9179-3573</orcidid><orcidid>https://orcid.org/0000-0002-0638-4100</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2020-11, Vol.15 (11), p.e0241507 |
| issn | 1932-6203 1932-6203 |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Artificial organs Biology and Life Sciences Cadaver Cadavers Computer applications Deviation Dynamic models Engineering and technology Experiments Flow (Dynamics) Human tissues Humans Hydrodynamics Hygiene Measurement Mechanical engineering Medical research Medicine and Health Sciences Models, Biological Obstructions Pattern analysis Penis Physical Sciences Physiological aspects Printing, Three-Dimensional Quality of life Relative vorticity Statistical analysis Surgery Three dimensional flow Three dimensional models Three dimensional printing Tissues Urethra Urethra - physiology Urination Urination - physiology Urine Urology Vorticity |
| title | Novel measurement tool and model for aberrant urinary stream in 3D printed urethras derived from human tissue |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T19%3A58%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Novel%20measurement%20tool%20and%20model%20for%20aberrant%20urinary%20stream%20in%203D%20printed%20urethras%20derived%20from%20human%20tissue&rft.jtitle=PloS%20one&rft.au=Cohen,%20Andrew%20J&rft.date=2020-11-11&rft.volume=15&rft.issue=11&rft.spage=e0241507&rft.pages=e0241507-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0241507&rft_dat=%3Cgale_plos_%3EA641243274%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2459615593&rft_id=info:pmid/33175862&rft_galeid=A641243274&rft_doaj_id=oai_doaj_org_article_4c6d6982708a4f74a5ee5829cf1d799a&rfr_iscdi=true |