The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu)

Glaucoma represents the second main cause of irreversible loss of eyesight worldwide. Progression of the disease is due to changes around the optic nerve, eye structure and optic nerve environment. Focusing on primary congenital glaucoma, which is not completely understood, we report an evaluation o...

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Veröffentlicht in:	PloS one 2020-11, Vol.15 (11), p.e0241902
Hauptverfasser:	Alghamdi, Amani, Aldossary, Wadha, Albahkali, Sarah, Alotaibi, Batoul, Alrfaei, Bahauddeen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Amino Acid Substitution Animals Antibiotics Apoptosis Astrocytes Astrocytes - cytology Astrocytes - metabolism Biochemistry Biology and Life Sciences Brain research Care and treatment Cell Proliferation Cell survival Cells, Cultured Complications CRISPR CRISPR-Cas Systems CYP1B1 gene Cytochrome P-450 Cytochrome P-450 CYP1B1 - genetics Cytokines Cytokines - metabolism Development and progression Enzymes Evaluation Eye Ganglion cells Gene mutation Genetic aspects Glaucoma Glaucoma - congenital Glaucoma - genetics Glial cells Health aspects Homeostasis Humans Inflammation Kinases Male Medical research Medicine and Health Sciences Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Microglia Microglia - cytology Microglia - metabolism Models, Animal Mutation NADP NADP - metabolism NADPH-diaphorase Nicotinamide Nicotinamide adenine dinucleotide Optic nerve Point Mutation Rats Reagents Stem cells Surgery
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