Impact of diabetes mellitus on postoperative outcomes in individuals with non-small-cell lung cancer: A retrospective cohort study
Studies showing that individuals with non-small cell lung cancer (NSCLC) and diabetes mellitus (DM) have reported poor outcomes after pulmonary resection with varying results. Therefore, we investigated the clinical impact of preoperative DM on postoperative morbidity and survival in individuals wit...
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| creator | Komatsu, Teruya Chen-Yoshikawa, Toyofumi F Ikeda, Masaki Takahashi, Koji Nishimura, Akiko Harashima, Shin-Ichi Date, Hiroshi |
| description | Studies showing that individuals with non-small cell lung cancer (NSCLC) and diabetes mellitus (DM) have reported poor outcomes after pulmonary resection with varying results. Therefore, we investigated the clinical impact of preoperative DM on postoperative morbidity and survival in individuals with resectable NSCLC.
Data of individuals who underwent pulmonary resection for NSCLC from 2000 to 2015 were extracted from the database of Kyoto University Hospital. The primary endpoint was the incidence of postoperative complications, and secondary endpoints were postoperative length of hospital stay and overall survival. The survival rate was analyzed using the Kaplan-Meier method.
A total of 2,219 patients were eligible for the study. The median age of participants was 67 years. Among them, 39.5% were women, and 259 (11.7%) presented with DM. The effect of DM on the incidence of postoperative complications and postoperative length of hospital stay was not significant. Although the 5-year survival rates were similar in both patients with and without DM (80.2% versus 79.4%; p = 0.158), those with DM who had a hemoglobin A1c level ≥ 8.0% had the worst survival.
In individuals with resectable NSCLC, preoperative DM does not influence the acute phase postoperative recovery. However, poorly controlled preoperative DM could lead to low postoperative survival rates. |
| doi_str_mv | 10.1371/journal.pone.0241930 |
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Data of individuals who underwent pulmonary resection for NSCLC from 2000 to 2015 were extracted from the database of Kyoto University Hospital. The primary endpoint was the incidence of postoperative complications, and secondary endpoints were postoperative length of hospital stay and overall survival. The survival rate was analyzed using the Kaplan-Meier method.
A total of 2,219 patients were eligible for the study. The median age of participants was 67 years. Among them, 39.5% were women, and 259 (11.7%) presented with DM. The effect of DM on the incidence of postoperative complications and postoperative length of hospital stay was not significant. Although the 5-year survival rates were similar in both patients with and without DM (80.2% versus 79.4%; p = 0.158), those with DM who had a hemoglobin A1c level ≥ 8.0% had the worst survival.
In individuals with resectable NSCLC, preoperative DM does not influence the acute phase postoperative recovery. However, poorly controlled preoperative DM could lead to low postoperative survival rates.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0241930</identifier><identifier>PMID: 33166327</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Biology and life sciences ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - surgery ; Cardiovascular disease ; Care and treatment ; Case-Control Studies ; Classification ; Cohort analysis ; Complications ; Complications and side effects ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - mortality ; Female ; Glucose ; Glycated Hemoglobin A - metabolism ; Health sciences ; Hemoglobin ; Hospitals ; Humans ; Incidence ; Japan - epidemiology ; Kaplan-Meier Estimate ; Length of Stay ; Lung cancer ; Lung diseases ; Lung Neoplasms - metabolism ; Lung Neoplasms - mortality ; Lung Neoplasms - surgery ; Male ; Medical prognosis ; Medicine ; Medicine and Health Sciences ; Methods ; Middle Aged ; Morbidity ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Patient outcomes ; Patients ; Postoperative care ; Postoperative Period ; Pulmonary Surgical Procedures ; Retrospective Studies ; Small cell lung carcinoma ; Surgery ; Surgical outcomes ; Survival ; Survival Rate ; Thoracic surgery</subject><ispartof>PloS one, 2020-11, Vol.15 (11), p.e0241930-e0241930</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Komatsu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Komatsu et al 2020 Komatsu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-5aaf38f8206797d25fafbeaf19bbdfa658cc6eb1d6763b7e06c78086aad47913</citedby><cites>FETCH-LOGICAL-c692t-5aaf38f8206797d25fafbeaf19bbdfa658cc6eb1d6763b7e06c78086aad47913</cites><orcidid>0000-0001-6321-2973</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652320/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652320/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23853,27911,27912,53778,53780,79355,79356</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33166327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Taniyama, Yoshiaki</contributor><creatorcontrib>Komatsu, Teruya</creatorcontrib><creatorcontrib>Chen-Yoshikawa, Toyofumi F</creatorcontrib><creatorcontrib>Ikeda, Masaki</creatorcontrib><creatorcontrib>Takahashi, Koji</creatorcontrib><creatorcontrib>Nishimura, Akiko</creatorcontrib><creatorcontrib>Harashima, Shin-Ichi</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><title>Impact of diabetes mellitus on postoperative outcomes in individuals with non-small-cell lung cancer: A retrospective cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Studies showing that individuals with non-small cell lung cancer (NSCLC) and diabetes mellitus (DM) have reported poor outcomes after pulmonary resection with varying results. Therefore, we investigated the clinical impact of preoperative DM on postoperative morbidity and survival in individuals with resectable NSCLC.
Data of individuals who underwent pulmonary resection for NSCLC from 2000 to 2015 were extracted from the database of Kyoto University Hospital. The primary endpoint was the incidence of postoperative complications, and secondary endpoints were postoperative length of hospital stay and overall survival. The survival rate was analyzed using the Kaplan-Meier method.
A total of 2,219 patients were eligible for the study. The median age of participants was 67 years. Among them, 39.5% were women, and 259 (11.7%) presented with DM. The effect of DM on the incidence of postoperative complications and postoperative length of hospital stay was not significant. Although the 5-year survival rates were similar in both patients with and without DM (80.2% versus 79.4%; p = 0.158), those with DM who had a hemoglobin A1c level ≥ 8.0% had the worst survival.
In individuals with resectable NSCLC, preoperative DM does not influence the acute phase postoperative recovery. However, poorly controlled preoperative DM could lead to low postoperative survival rates.</description><subject>Aged</subject><subject>Biology and life sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Classification</subject><subject>Cohort analysis</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - mortality</subject><subject>Female</subject><subject>Glucose</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Health sciences</subject><subject>Hemoglobin</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - 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metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Classification</topic><topic>Cohort analysis</topic><topic>Complications</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus - mortality</topic><topic>Female</topic><topic>Glucose</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Health sciences</topic><topic>Hemoglobin</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Kaplan-Meier Estimate</topic><topic>Length of Stay</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Komatsu, Teruya</au><au>Chen-Yoshikawa, Toyofumi F</au><au>Ikeda, Masaki</au><au>Takahashi, Koji</au><au>Nishimura, Akiko</au><au>Harashima, Shin-Ichi</au><au>Date, Hiroshi</au><au>Taniyama, Yoshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of diabetes mellitus on postoperative outcomes in individuals with non-small-cell lung cancer: A retrospective cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-11-09</date><risdate>2020</risdate><volume>15</volume><issue>11</issue><spage>e0241930</spage><epage>e0241930</epage><pages>e0241930-e0241930</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Studies showing that individuals with non-small cell lung cancer (NSCLC) and diabetes mellitus (DM) have reported poor outcomes after pulmonary resection with varying results. Therefore, we investigated the clinical impact of preoperative DM on postoperative morbidity and survival in individuals with resectable NSCLC.
Data of individuals who underwent pulmonary resection for NSCLC from 2000 to 2015 were extracted from the database of Kyoto University Hospital. The primary endpoint was the incidence of postoperative complications, and secondary endpoints were postoperative length of hospital stay and overall survival. The survival rate was analyzed using the Kaplan-Meier method.
A total of 2,219 patients were eligible for the study. The median age of participants was 67 years. Among them, 39.5% were women, and 259 (11.7%) presented with DM. The effect of DM on the incidence of postoperative complications and postoperative length of hospital stay was not significant. Although the 5-year survival rates were similar in both patients with and without DM (80.2% versus 79.4%; p = 0.158), those with DM who had a hemoglobin A1c level ≥ 8.0% had the worst survival.
In individuals with resectable NSCLC, preoperative DM does not influence the acute phase postoperative recovery. However, poorly controlled preoperative DM could lead to low postoperative survival rates.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33166327</pmid><doi>10.1371/journal.pone.0241930</doi><tpages>e0241930</tpages><orcidid>https://orcid.org/0000-0001-6321-2973</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2458949709 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Biology and life sciences Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - surgery Cardiovascular disease Care and treatment Case-Control Studies Classification Cohort analysis Complications Complications and side effects Diabetes Diabetes mellitus Diabetes Mellitus - epidemiology Diabetes Mellitus - metabolism Diabetes Mellitus - mortality Female Glucose Glycated Hemoglobin A - metabolism Health sciences Hemoglobin Hospitals Humans Incidence Japan - epidemiology Kaplan-Meier Estimate Length of Stay Lung cancer Lung diseases Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - surgery Male Medical prognosis Medicine Medicine and Health Sciences Methods Middle Aged Morbidity Non-small cell lung cancer Non-small cell lung carcinoma Patient outcomes Patients Postoperative care Postoperative Period Pulmonary Surgical Procedures Retrospective Studies Small cell lung carcinoma Surgery Surgical outcomes Survival Survival Rate Thoracic surgery |
| title | Impact of diabetes mellitus on postoperative outcomes in individuals with non-small-cell lung cancer: A retrospective cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T17%3A33%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20diabetes%20mellitus%20on%20postoperative%20outcomes%20in%20individuals%20with%20non-small-cell%20lung%20cancer:%20A%20retrospective%20cohort%20study&rft.jtitle=PloS%20one&rft.au=Komatsu,%20Teruya&rft.date=2020-11-09&rft.volume=15&rft.issue=11&rft.spage=e0241930&rft.epage=e0241930&rft.pages=e0241930-e0241930&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0241930&rft_dat=%3Cgale_plos_%3EA641043157%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2458949709&rft_id=info:pmid/33166327&rft_galeid=A641043157&rft_doaj_id=oai_doaj_org_article_a79947491ecc485d91113932c8ccb167&rfr_iscdi=true |