A multivariate, quantitative assay that disentangles key kinetic parameters of primary human T cell function in vitro

Cell therapy is poised to play a larger role in medicine, most notably for immuno-oncology. Despite the recent success of CAR-T therapeutics in the treatment of blood tumors and the rapid progress toward improved versions of both CAR- and TCR-Ts, important analytical aspects of preclinical developme...

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Veröffentlicht in:	PloS one 2020-11, Vol.15 (11), p.e0241421-e0241421
Hauptverfasser:	Huang, Grace L, Nampe, Daniel P, Yi, Jason, Gabrelow, Grant B, Negri, Kathleen R, Kamb, Alexander, Xu, Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Assaying Biochemical assays Biology and Life Sciences Cancer immunotherapy Cell death Cell growth Cell Line Cell Proliferation Cell receptors Cell research Cell therapy Cellular therapy Cytotoxicity Cytotoxicity, Immunologic Effector cells Flow cytometry Health aspects Huang, Daniel Humans Immunoassay - methods Kinetics Lymphocytes Lymphocytes T Major histocompatibility complex Medicine and Health Sciences Multivariate Analysis Oncology Parameters Peptides Physiological aspects Quantitative analysis Receptors, Antigen, T-Cell - metabolism Research and Analysis Methods T cell proliferation T cell receptors T cells T-cell receptor T-Lymphocytes - cytology T-Lymphocytes - immunology Toxicity Tumors
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