Lipopolysaccharide triggers different transcriptional signatures in taurine and indicine cattle macrophages: Reactive oxygen species and potential outcomes to the development of immune response to infections

Macrophages are classified upon activation as classical activated M1 and M2 anti-inflammatory regulatory populations. This macrophage polarization is well characterized in humans and mice, but M1/M2 profile in cattle has been far less explored. Bos primigenius taurus (taurine) and Bos primigenius in...

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Veröffentlicht in:	PloS one 2020-11, Vol.15 (11), p.e0241861
Hauptverfasser:	Daibert, Raquel Morais de Paiva, de Biagi Junior, Carlos Alberto Oliveira, Vieira, Felipe de Oliveira, da Silva, Marcos Vinicius Gualberto Barbosa, Hottz, Eugenio Damaceno, Mendonça Pinheiro, Mariana Brandi, Faza, Daniele Ribeiro de Lima Reis, Pereira, Hyago Passe, Martins, Marta Fonseca, Brandão, Humberto de Mello, Machado, Marco Antônio, Carvalho, Wanessa Araújo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute phase proteins Acute phase substances Amyloid Animal models Animals Biological activity Biology and Life Sciences Bos primigenius Breeding Buffy coat Cattle CCR5 protein Cell adhesion Cell culture Cell cycle Cell Differentiation - drug effects Chemokines Communicable diseases Computer and Information Sciences Cytokines Dairy cattle Engineering and Technology Extracellular matrix Gene expression Gene Expression Profiling - veterinary Gene Expression Regulation - drug effects Gene Regulatory Networks - drug effects Gene sequencing Genes Genetic aspects Health aspects Immune response Immune system Infections Inflammation Inflammatory response Leukocyte migration Leukocytes Lipopolysaccharides Lipopolysaccharides - adverse effects Lipopolysaccharides - pharmacology Macrophage Activation Macrophages Macrophages - chemistry Macrophages - drug effects Medical research Medicine and Health Sciences Monocytes Nitric oxide Nitric-oxide synthase Oxygen Parasites Parasitic diseases Prevention Reactive oxygen species Reactive Oxygen Species - metabolism Receptors Research and analysis methods Ribonucleic acid RNA Sequence Analysis, RNA - veterinary Signatures Species Specificity TLR4 protein Toll-like receptors Transcription
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