A model mimicking catabolic inflammatory disease; a controlled randomized study in humans

Inflammatory disease is catabolic and associated with insulin resistance, increased energy expenditure, lipolysis and muscle protein loss. The main contributors to these metabolic adaptations are inflammation, malnutrition and immobilisation. Controlled experimental models incorporating these centra...

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Veröffentlicht in:	PloS one 2020-11, Vol.15 (11), p.e0241274-e0241274
Hauptverfasser:	Mose, Maike, Rittig, Nikolaj, Mikkelsen, Ulla Ramer, Jessen, Niels, Bengtsen, Mads Bisgaard, Christensen, Brit, Jørgensen, Jens Otto Lunde, Møller, Niels
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adult Bed rest Biological models Biology and Life Sciences Biomarkers - metabolism Biopsy Calorimetry Catabolism Catheters Development and progression Diabetes Disease control Endocrinology Energy expenditure Evaluation Fasting Glucagon Glucose Glucose Clamp Technique Health aspects Hospitals Humans Immobilization Inflammation Inflammation - pathology Inflammatory diseases Insulin Insulin Resistance Internal medicine Kinases Kinetics Lipid peroxidation Lipids Lipids - analysis Lipolysis Lipopolysaccharides Malnutrition Medicine Medicine and Health Sciences Metabolism Mimicry Models, Biological Muscle, Skeletal - metabolism Muscles Oxidation Palmitic acid Phenylalanine Physical Sciences Physiological aspects Proteins Proteins - analysis Research and Analysis Methods Sensitivity Signal Transduction Substrates Tracers Tyrosine Urea Veins & arteries Young Adult
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