The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship

To elucidate how variants in genetic risk loci previously implicated in Alzheimer's Disease (AD) and/or frontotemporal dementia (FTD) contribute to expression of disease phenotypes, a phenome-wide association study was performed in two waves. In the first wave, we explored clinical traits assoc...

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Veröffentlicht in:	PloS one 2020-11, Vol.15 (11), p.e0241552-e0241552
Hauptverfasser:	Li, Qingqin S, Tian, Chao, Hinds, David, Seabrook, Guy R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer's disease Angina Apolipoprotein E Apolipoproteins E - genetics Arteriosclerosis Asthma Atherosclerosis Autoimmune diseases Biobanks Biology and Life Sciences Biomarkers Brain research Cardiovascular diseases Coronary artery disease Dementia Dementia disorders Deoxyribonucleic acid DNA Drb1 protein Frontotemporal dementia Frontotemporal Dementia - genetics Genealogy Genes Genetic aspects Genetic diversity Genetic Loci Genetic Predisposition to Disease Genetic variance Genome-Wide Association Study Genomes Genomics Health aspects Health risk assessment Health risks Heart diseases Hematology Histocompatibility antigen HLA Humans Hypertension Ischemia Leukocytes Loci Medicine and Health Sciences Mendelian Randomization Analysis Metabolism Microglia Monocytes Myopia Neurodegenerative diseases Neuroimaging Phenotype Phenotypes Platelets Pleiotropy Proteins Quantitative Trait Loci - genetics R&D Research & development Research and Analysis Methods Risk Risk Factors Support vector machines Thrombocytes
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