Targeted detection and quantitation of histone modifications from 1,000 cells

Histone post-translational modifications (PTMs) create a powerful regulatory mechanism for maintaining chromosomal integrity in cells. Histone acetylation and methylation, the most widely studied histone PTMs, act in concert with chromatin-associated proteins to control access to genetic information...

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Veröffentlicht in:	PloS one 2020-10, Vol.15 (10), p.e0240829-e0240829
Hauptverfasser:	Abshiru, Nebiyu A, Sikora, Jacek W, Camarillo, Jeannie M, Morris, Juliette A, Compton, Philip D, Lee, Tak, Neelamraju, Yaseswini, Haddox, Samuel, Sheridan, Caroline, Carroll, Martin, Cripe, Larry D, Tallman, Martin S, Paietta, Elisabeth M, Melnick, Ari M, Thomas, Paul M, Garrett-Bakelman, Francine E, Kelleher, Neil L
Format:	Artikel
Sprache:	eng
Schlagworte:	Access control Acetylation Acute myeloid leukemia Antibodies Biochemistry Biology and life sciences Biomarkers Bone marrow Cancer Cell cycle Cell Line Cells (Biology) Chemistry Chromatin Chromatography, Liquid - methods Departments Gene expression Hematology Histones Histones - genetics Histones - metabolism Humans Leukemia Mass spectrometry Mass spectroscopy Medicine Medicine and Health Sciences Methylation Myeloid leukemia Observations Oncology Peptides Peptides - chemistry Physical Sciences Physiological aspects Post-translation Post-translational modifications Protein Processing, Post-Translational - genetics Proteins Proteomics Proteomics - methods Quantitation Regulatory mechanisms (biology) Sample preparation Stem cells Tandem Mass Spectrometry - methods Transcription
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