Omega-3 fatty acid supplement use and oxidative stress levels in pregnancy
Oxidative stress is a biological imbalance in reactive oxygen species and antioxidants. Increased oxidative stress during pregnancy has been associated with adverse birth outcomes. Omega-3 fatty acid (n-3 FA) supplementation may decrease oxidative stress; however, this relationship is seldom examine...
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| description | Oxidative stress is a biological imbalance in reactive oxygen species and antioxidants. Increased oxidative stress during pregnancy has been associated with adverse birth outcomes. Omega-3 fatty acid (n-3 FA) supplementation may decrease oxidative stress; however, this relationship is seldom examined during pregnancy. This study assessed the association between n-3 FA supplement use during pregnancy and urinary oxidative stress biomarker concentrations. Data came from The Infant Development and the Environment Study (TIDES), a prospective cohort study that recruited pregnant women in 4 US cities between 2010-2012. Third trimester n-3 FA intake was self-reported. Third trimester urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) was measured as an oxidative stress biomarker. Additionally, we measured the major metabolite of 8-iso-PGF2α and Prostaglandin F2α (PGF2α) and utilized the 8-iso-PGF2α to PGF2α ratio to calculate the change in 8-iso-PGF2α reflecting oxidative stress versus inflammation. Adjusted linear models were used to determine associations with control for confounding. Of 725 women, 165 reported n-3 FA supplement use in the third trimester. In adjusted linear models, n-3 FA use was associated with 10.2% lower levels of 8-iso-PGF2α (95% Confidence Interval [CI]: -19.6, 0.25) and 10.3% lower levels of the metabolite (95% CI: -17.1, -2.91). No associations were observed with PGF2α. The lower levels of 8-iso-PGF2α appeared to reflect a decrease in oxidative stress (percent change with supplement use: -18.7, 95% CI: -30.1, -5.32) rather than inflammation. Overall, third trimester n-3 FA intake was associated with lower concentrations of 8-iso-PGF2α and its metabolite, suggesting a decrease in maternal oxidative stress during pregnancy. |
| doi_str_mv | 10.1371/journal.pone.0240244 |
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Increased oxidative stress during pregnancy has been associated with adverse birth outcomes. Omega-3 fatty acid (n-3 FA) supplementation may decrease oxidative stress; however, this relationship is seldom examined during pregnancy. This study assessed the association between n-3 FA supplement use during pregnancy and urinary oxidative stress biomarker concentrations. Data came from The Infant Development and the Environment Study (TIDES), a prospective cohort study that recruited pregnant women in 4 US cities between 2010-2012. Third trimester n-3 FA intake was self-reported. Third trimester urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) was measured as an oxidative stress biomarker. Additionally, we measured the major metabolite of 8-iso-PGF2α and Prostaglandin F2α (PGF2α) and utilized the 8-iso-PGF2α to PGF2α ratio to calculate the change in 8-iso-PGF2α reflecting oxidative stress versus inflammation. Adjusted linear models were used to determine associations with control for confounding. Of 725 women, 165 reported n-3 FA supplement use in the third trimester. In adjusted linear models, n-3 FA use was associated with 10.2% lower levels of 8-iso-PGF2α (95% Confidence Interval [CI]: -19.6, 0.25) and 10.3% lower levels of the metabolite (95% CI: -17.1, -2.91). No associations were observed with PGF2α. The lower levels of 8-iso-PGF2α appeared to reflect a decrease in oxidative stress (percent change with supplement use: -18.7, 95% CI: -30.1, -5.32) rather than inflammation. Overall, third trimester n-3 FA intake was associated with lower concentrations of 8-iso-PGF2α and its metabolite, suggesting a decrease in maternal oxidative stress during pregnancy.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0240244</identifier><identifier>PMID: 33095772</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Antioxidants ; Antioxidants - therapeutic use ; Biology and Life Sciences ; Biomarkers ; Confidence intervals ; Density ; Dietary Supplements ; Environmental health ; Epidemiology ; Fatty acids ; Fatty Acids, Omega-3 - therapeutic use ; Female ; Food and nutrition ; Health aspects ; Health care ; Health sciences ; Humans ; Inflammation ; Lipid peroxidation ; Lipids ; Maternal & child health ; Medicine and Health Sciences ; Metabolites ; Omega 3 fatty acids ; Oxidation-Reduction - drug effects ; Oxidative stress ; Oxidative Stress - drug effects ; Oxygen ; Pediatrics ; Physical Sciences ; Pregnancy ; Pregnancy Trimester, Third ; Pregnant women ; Prevention ; Preventive medicine ; Prospective Studies ; Questionnaires ; Reactive oxygen species ; Supplementation ; Supplements ; Surveys and Questionnaires ; Urine ; Womens health</subject><ispartof>PloS one, 2020-10, Vol.15 (10), p.e0240244</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. 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Increased oxidative stress during pregnancy has been associated with adverse birth outcomes. Omega-3 fatty acid (n-3 FA) supplementation may decrease oxidative stress; however, this relationship is seldom examined during pregnancy. This study assessed the association between n-3 FA supplement use during pregnancy and urinary oxidative stress biomarker concentrations. Data came from The Infant Development and the Environment Study (TIDES), a prospective cohort study that recruited pregnant women in 4 US cities between 2010-2012. Third trimester n-3 FA intake was self-reported. Third trimester urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) was measured as an oxidative stress biomarker. Additionally, we measured the major metabolite of 8-iso-PGF2α and Prostaglandin F2α (PGF2α) and utilized the 8-iso-PGF2α to PGF2α ratio to calculate the change in 8-iso-PGF2α reflecting oxidative stress versus inflammation. Adjusted linear models were used to determine associations with control for confounding. Of 725 women, 165 reported n-3 FA supplement use in the third trimester. In adjusted linear models, n-3 FA use was associated with 10.2% lower levels of 8-iso-PGF2α (95% Confidence Interval [CI]: -19.6, 0.25) and 10.3% lower levels of the metabolite (95% CI: -17.1, -2.91). No associations were observed with PGF2α. The lower levels of 8-iso-PGF2α appeared to reflect a decrease in oxidative stress (percent change with supplement use: -18.7, 95% CI: -30.1, -5.32) rather than inflammation. Overall, third trimester n-3 FA intake was associated with lower concentrations of 8-iso-PGF2α and its metabolite, suggesting a decrease in maternal oxidative stress during pregnancy.</description><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - therapeutic use</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Confidence intervals</subject><subject>Density</subject><subject>Dietary Supplements</subject><subject>Environmental health</subject><subject>Epidemiology</subject><subject>Fatty acids</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Female</subject><subject>Food and nutrition</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Health sciences</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Maternal & child health</subject><subject>Medicine and Health Sciences</subject><subject>Metabolites</subject><subject>Omega 3 fatty acids</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxygen</subject><subject>Pediatrics</subject><subject>Physical Sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Third</subject><subject>Pregnant women</subject><subject>Prevention</subject><subject>Preventive medicine</subject><subject>Prospective Studies</subject><subject>Questionnaires</subject><subject>Reactive oxygen species</subject><subject>Supplementation</subject><subject>Supplements</subject><subject>Surveys and Questionnaires</subject><subject>Urine</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkm2L1DAUhYso7rr6D0QDguCHGdOmSdsvwrL4MrIw4NvXcCe57WRom26SDjv_3qzTXaagIA20JM85vZycJHmZ0mXKivT9zo6uh3Y52B6XNMvjyh8l52nFsoXIKHt88n2WPPN-RylnpRBPkzPGaMWLIjtPvq47bGDBSA0hHAgoo4kfh6HFDvtARo8Eek3srdEQzB6JDw69Jy3usfXE9GRw2PTQq8Pz5EkNrccX0_si-fnp44-rL4vr9efV1eX1QokqC4siKxjUTMVFM12BQmBYMKV4WpXIQZeF2DDMuSq1qMpU6QwYy6OqpJwKYBfJ66Pv0Fovpxi8zHLOKpoJTiOxOhLawk4OznTgDtKCkX82rGskuGBUizJPN6lGUbG8rGOEUAq14YXStdKijrNFrw_T38ZNh1rFVBy0M9P5SW-2srF7WfAyTwsWDd5MBs7ejOjDP0aeqAbiVKavbTRTnfFKXgpWxesVnEdq-RcqPho7o2IRahP3Z4J3M0FkAt6GBkbv5er7t_9n17_m7NsTdovQhq237RiM7f0czI-gctZ7h_VDcimVdz2-T0Pe9VhOPY6yV6epP4jui8t-A-z57Yo</recordid><startdate>20201023</startdate><enddate>20201023</enddate><creator>Sley, Erin G</creator><creator>Rosen, Emma M</creator><creator>van 't Erve, Thomas J</creator><creator>Sathyanarayana, Sheela</creator><creator>Barrett, Emily S</creator><creator>Nguyen, Ruby H N</creator><creator>Bush, Nicole R</creator><creator>Milne, Ginger L</creator><creator>Swan, Shanna H</creator><creator>Ferguson, Kelly K</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8467-3250</orcidid></search><sort><creationdate>20201023</creationdate><title>Omega-3 fatty acid supplement use and oxidative stress levels in pregnancy</title><author>Sley, Erin G ; Rosen, Emma M ; van 't Erve, Thomas J ; Sathyanarayana, Sheela ; Barrett, Emily S ; Nguyen, Ruby H N ; Bush, Nicole R ; Milne, Ginger L ; Swan, Shanna H ; Ferguson, Kelly K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-7273af3cf3c02d9acea3e73cc5198e5ad876b3e45c8d6981cd2a33427380506a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - 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Increased oxidative stress during pregnancy has been associated with adverse birth outcomes. Omega-3 fatty acid (n-3 FA) supplementation may decrease oxidative stress; however, this relationship is seldom examined during pregnancy. This study assessed the association between n-3 FA supplement use during pregnancy and urinary oxidative stress biomarker concentrations. Data came from The Infant Development and the Environment Study (TIDES), a prospective cohort study that recruited pregnant women in 4 US cities between 2010-2012. Third trimester n-3 FA intake was self-reported. Third trimester urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) was measured as an oxidative stress biomarker. Additionally, we measured the major metabolite of 8-iso-PGF2α and Prostaglandin F2α (PGF2α) and utilized the 8-iso-PGF2α to PGF2α ratio to calculate the change in 8-iso-PGF2α reflecting oxidative stress versus inflammation. Adjusted linear models were used to determine associations with control for confounding. Of 725 women, 165 reported n-3 FA supplement use in the third trimester. In adjusted linear models, n-3 FA use was associated with 10.2% lower levels of 8-iso-PGF2α (95% Confidence Interval [CI]: -19.6, 0.25) and 10.3% lower levels of the metabolite (95% CI: -17.1, -2.91). No associations were observed with PGF2α. The lower levels of 8-iso-PGF2α appeared to reflect a decrease in oxidative stress (percent change with supplement use: -18.7, 95% CI: -30.1, -5.32) rather than inflammation. Overall, third trimester n-3 FA intake was associated with lower concentrations of 8-iso-PGF2α and its metabolite, suggesting a decrease in maternal oxidative stress during pregnancy.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33095772</pmid><doi>10.1371/journal.pone.0240244</doi><tpages>e0240244</tpages><orcidid>https://orcid.org/0000-0001-8467-3250</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2453902650 |
| source | MEDLINE; Full-Text Journals in Chemistry (Open access); Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Antioxidants Antioxidants - therapeutic use Biology and Life Sciences Biomarkers Confidence intervals Density Dietary Supplements Environmental health Epidemiology Fatty acids Fatty Acids, Omega-3 - therapeutic use Female Food and nutrition Health aspects Health care Health sciences Humans Inflammation Lipid peroxidation Lipids Maternal & child health Medicine and Health Sciences Metabolites Omega 3 fatty acids Oxidation-Reduction - drug effects Oxidative stress Oxidative Stress - drug effects Oxygen Pediatrics Physical Sciences Pregnancy Pregnancy Trimester, Third Pregnant women Prevention Preventive medicine Prospective Studies Questionnaires Reactive oxygen species Supplementation Supplements Surveys and Questionnaires Urine Womens health |
| title | Omega-3 fatty acid supplement use and oxidative stress levels in pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T13%3A55%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Omega-3%20fatty%20acid%20supplement%20use%20and%20oxidative%20stress%20levels%20in%20pregnancy&rft.jtitle=PloS%20one&rft.au=Sley,%20Erin%20G&rft.date=2020-10-23&rft.volume=15&rft.issue=10&rft.spage=e0240244&rft.pages=e0240244-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0240244&rft_dat=%3Cgale_plos_%3EA639240655%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2453902650&rft_id=info:pmid/33095772&rft_galeid=A639240655&rft_doaj_id=oai_doaj_org_article_41b1de69348f402a86cb57cdfcd6face&rfr_iscdi=true |