Prevalence and factors associated with physical function limitation in older West African people living with HIV
Although physical function decline is common with aging, the burden of this impairment remains underestimated in patients living with HIV (PLHIV), particularly in the older people receiving antiretroviral treatment (ART) and living in sub-Saharan Africa (SSA). PLHIV aged ≥50 years old and on ART sin...
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| Veröffentlicht in: | PloS one 2020-10, Vol.15 (10), p.e0240906 |
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| creator | Bernard, Charlotte Font, Hélène Diallo, Zélica Ahonon, Richard Tine, Judicaël Malick Abouo, Franklin Tanon, Aristophane Messou, Eugène Seydi, Moussa Dabis, François de Rekeneire, Nathalie |
| description | Although physical function decline is common with aging, the burden of this impairment remains underestimated in patients living with HIV (PLHIV), particularly in the older people receiving antiretroviral treatment (ART) and living in sub-Saharan Africa (SSA). PLHIV aged ≥50 years old and on ART since ≥6 months were included (N = 333) from three clinics (two in Côte d'Ivoire, one in Senegal) participating in the International epidemiological Databases to Evaluate AIDS (IeDEA) West Africa collaboration. Physical function was measured using the Short Physical Performance Battery (SPPB), the unipodal balance test and self-reported questionnaires. Grip strength was also assessed. Logistic regression was used to identify the factors associated with SPPB performance specifically. Median age was 57 (54-61) years, 57.7% were female and 82.7% had an undetectable viral load. The mean SPPB score was 10.2 ±1.8. Almost 30% had low SPPB performance with the 5-sit-to-stand test being the most altered subtest (64%). PLHIV with low SPPB performance also had significantly low performance on the unipodal balance test (54.2%, p = 0.001) and low mean grip strength (but only in men (p = 0.005)). They also showed some difficulties in daily life activities (climbing stairs, walking one block, both p |
| doi_str_mv | 10.1371/journal.pone.0240906 |
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PLHIV aged ≥50 years old and on ART since ≥6 months were included (N = 333) from three clinics (two in Côte d'Ivoire, one in Senegal) participating in the International epidemiological Databases to Evaluate AIDS (IeDEA) West Africa collaboration. Physical function was measured using the Short Physical Performance Battery (SPPB), the unipodal balance test and self-reported questionnaires. Grip strength was also assessed. Logistic regression was used to identify the factors associated with SPPB performance specifically. Median age was 57 (54-61) years, 57.7% were female and 82.7% had an undetectable viral load. The mean SPPB score was 10.2 ±1.8. Almost 30% had low SPPB performance with the 5-sit-to-stand test being the most altered subtest (64%). PLHIV with low SPPB performance also had significantly low performance on the unipodal balance test (54.2%, p = 0.001) and low mean grip strength (but only in men (p = 0.005)). They also showed some difficulties in daily life activities (climbing stairs, walking one block, both p<0.0001). Age ≥60 years (adjusted OR (aOR) = 3.4; CI95% = 1.9-5.9,), being a female (aOR = 2.1; CI95% = 1.1-4.1), having an abdominal obesity (aOR = 2.1; CI95% = 1.2-4.0), a longer duration of HIV infection (aOR = 2.9; CI95% = 1.5-5.7), old Nucleoside reverse transcriptase inhibitors (NRTIs) (i.e., AZT: zidovudine, ddI: didanosine, DDC: zalcitabine, D4T: stavudine) in current ART (aOR = 2.0 CI95% = 1.1-3.7) were associated with low SPPB performance. As in western countries, physical function limitation is now part of the burden of HIV disease complications of older PLHIV living in West Africa, putting this population at risk for disability. How to screen those impairments and integrate their management in the standards of care should be investigated, and specific research on developing adapted daily physical activity program might be conducted.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0240906</identifier><identifier>PMID: 33091061</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Anti-HIV Agents - therapeutic use ; Antiretroviral agents ; Antiretroviral drugs ; Antiretroviral therapy ; Balance ; Biology and Life Sciences ; Body mass index ; Chronic illnesses ; Complications ; Complications and side effects ; Cote d'Ivoire - epidemiology ; Cross-Sectional Studies ; Didanosine ; Disabilities ; Disease ; Distribution ; Epidemiology ; Exercise ; Female ; Grip strength ; HIV ; HIV infections ; HIV Infections - drug therapy ; HIV Infections - physiopathology ; Hospitals ; Human immunodeficiency virus ; Humans ; Infections ; Life Sciences ; Male ; Medical research ; Medicine and Health Sciences ; Middle age ; Middle Aged ; Nucleoside reverse transcriptase inhibitors ; Obesity ; Older people ; Patients ; Physical activity ; Physical Functional Performance ; Population ; Postural Balance - physiology ; Prevalence ; Risk Factors ; RNA-directed DNA polymerase ; Santé publique et épidémiologie ; Self Report ; Senegal - epidemiology ; Standard of Care ; Stavudine ; Tropical diseases ; Zalcitabine ; Zidovudine</subject><ispartof>PloS one, 2020-10, Vol.15 (10), p.e0240906</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Bernard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>2020 Bernard et al 2020 Bernard et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c726t-1fad41a0ff0b975445fa867165c5aaa1906f2f759fc0486b442edd952c5966823</citedby><cites>FETCH-LOGICAL-c726t-1fad41a0ff0b975445fa867165c5aaa1906f2f759fc0486b442edd952c5966823</cites><orcidid>0000-0003-2677-4023 ; 0000-0002-1614-8857</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580884/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580884/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79472,79473</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33091061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03109834$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Mayne, Elizabeth S.</contributor><creatorcontrib>Bernard, Charlotte</creatorcontrib><creatorcontrib>Font, Hélène</creatorcontrib><creatorcontrib>Diallo, Zélica</creatorcontrib><creatorcontrib>Ahonon, Richard</creatorcontrib><creatorcontrib>Tine, Judicaël Malick</creatorcontrib><creatorcontrib>Abouo, Franklin</creatorcontrib><creatorcontrib>Tanon, Aristophane</creatorcontrib><creatorcontrib>Messou, Eugène</creatorcontrib><creatorcontrib>Seydi, Moussa</creatorcontrib><creatorcontrib>Dabis, François</creatorcontrib><creatorcontrib>de Rekeneire, Nathalie</creatorcontrib><creatorcontrib>IeDEA West Africa Cohort Collaboration</creatorcontrib><creatorcontrib>The IeDEA West Africa Cohort Collaboration</creatorcontrib><title>Prevalence and factors associated with physical function limitation in older West African people living with HIV</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Although physical function decline is common with aging, the burden of this impairment remains underestimated in patients living with HIV (PLHIV), particularly in the older people receiving antiretroviral treatment (ART) and living in sub-Saharan Africa (SSA). PLHIV aged ≥50 years old and on ART since ≥6 months were included (N = 333) from three clinics (two in Côte d'Ivoire, one in Senegal) participating in the International epidemiological Databases to Evaluate AIDS (IeDEA) West Africa collaboration. Physical function was measured using the Short Physical Performance Battery (SPPB), the unipodal balance test and self-reported questionnaires. Grip strength was also assessed. Logistic regression was used to identify the factors associated with SPPB performance specifically. Median age was 57 (54-61) years, 57.7% were female and 82.7% had an undetectable viral load. The mean SPPB score was 10.2 ±1.8. Almost 30% had low SPPB performance with the 5-sit-to-stand test being the most altered subtest (64%). PLHIV with low SPPB performance also had significantly low performance on the unipodal balance test (54.2%, p = 0.001) and low mean grip strength (but only in men (p = 0.005)). They also showed some difficulties in daily life activities (climbing stairs, walking one block, both p<0.0001). Age ≥60 years (adjusted OR (aOR) = 3.4; CI95% = 1.9-5.9,), being a female (aOR = 2.1; CI95% = 1.1-4.1), having an abdominal obesity (aOR = 2.1; CI95% = 1.2-4.0), a longer duration of HIV infection (aOR = 2.9; CI95% = 1.5-5.7), old Nucleoside reverse transcriptase inhibitors (NRTIs) (i.e., AZT: zidovudine, ddI: didanosine, DDC: zalcitabine, D4T: stavudine) in current ART (aOR = 2.0 CI95% = 1.1-3.7) were associated with low SPPB performance. As in western countries, physical function limitation is now part of the burden of HIV disease complications of older PLHIV living in West Africa, putting this population at risk for disability. How to screen those impairments and integrate their management in the standards of care should be investigated, and specific research on developing adapted daily physical activity program might be conducted.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral therapy</subject><subject>Balance</subject><subject>Biology and Life Sciences</subject><subject>Body mass index</subject><subject>Chronic illnesses</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Cote d'Ivoire - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Didanosine</subject><subject>Disabilities</subject><subject>Disease</subject><subject>Distribution</subject><subject>Epidemiology</subject><subject>Exercise</subject><subject>Female</subject><subject>Grip strength</subject><subject>HIV</subject><subject>HIV infections</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - physiopathology</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Nucleoside reverse transcriptase inhibitors</subject><subject>Obesity</subject><subject>Older people</subject><subject>Patients</subject><subject>Physical activity</subject><subject>Physical Functional Performance</subject><subject>Population</subject><subject>Postural Balance - physiology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>RNA-directed DNA polymerase</subject><subject>Santé publique et épidémiologie</subject><subject>Self Report</subject><subject>Senegal - epidemiology</subject><subject>Standard of Care</subject><subject>Stavudine</subject><subject>Tropical 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernard, Charlotte</au><au>Font, Hélène</au><au>Diallo, Zélica</au><au>Ahonon, Richard</au><au>Tine, Judicaël Malick</au><au>Abouo, Franklin</au><au>Tanon, Aristophane</au><au>Messou, Eugène</au><au>Seydi, Moussa</au><au>Dabis, François</au><au>de Rekeneire, Nathalie</au><au>Mayne, Elizabeth S.</au><aucorp>IeDEA West Africa Cohort Collaboration</aucorp><aucorp>The IeDEA West Africa Cohort Collaboration</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and factors associated with physical function limitation in older West African people living with HIV</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-10-22</date><risdate>2020</risdate><volume>15</volume><issue>10</issue><spage>e0240906</spage><pages>e0240906-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Although physical function decline is common with aging, the burden of this impairment remains underestimated in patients living with HIV (PLHIV), particularly in the older people receiving antiretroviral treatment (ART) and living in sub-Saharan Africa (SSA). PLHIV aged ≥50 years old and on ART since ≥6 months were included (N = 333) from three clinics (two in Côte d'Ivoire, one in Senegal) participating in the International epidemiological Databases to Evaluate AIDS (IeDEA) West Africa collaboration. Physical function was measured using the Short Physical Performance Battery (SPPB), the unipodal balance test and self-reported questionnaires. Grip strength was also assessed. Logistic regression was used to identify the factors associated with SPPB performance specifically. Median age was 57 (54-61) years, 57.7% were female and 82.7% had an undetectable viral load. The mean SPPB score was 10.2 ±1.8. Almost 30% had low SPPB performance with the 5-sit-to-stand test being the most altered subtest (64%). PLHIV with low SPPB performance also had significantly low performance on the unipodal balance test (54.2%, p = 0.001) and low mean grip strength (but only in men (p = 0.005)). They also showed some difficulties in daily life activities (climbing stairs, walking one block, both p<0.0001). Age ≥60 years (adjusted OR (aOR) = 3.4; CI95% = 1.9-5.9,), being a female (aOR = 2.1; CI95% = 1.1-4.1), having an abdominal obesity (aOR = 2.1; CI95% = 1.2-4.0), a longer duration of HIV infection (aOR = 2.9; CI95% = 1.5-5.7), old Nucleoside reverse transcriptase inhibitors (NRTIs) (i.e., AZT: zidovudine, ddI: didanosine, DDC: zalcitabine, D4T: stavudine) in current ART (aOR = 2.0 CI95% = 1.1-3.7) were associated with low SPPB performance. As in western countries, physical function limitation is now part of the burden of HIV disease complications of older PLHIV living in West Africa, putting this population at risk for disability. How to screen those impairments and integrate their management in the standards of care should be investigated, and specific research on developing adapted daily physical activity program might be conducted.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33091061</pmid><doi>10.1371/journal.pone.0240906</doi><tpages>e0240906</tpages><orcidid>https://orcid.org/0000-0003-2677-4023</orcidid><orcidid>https://orcid.org/0000-0002-1614-8857</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-10, Vol.15 (10), p.e0240906 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2453677514 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Aging Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Balance Biology and Life Sciences Body mass index Chronic illnesses Complications Complications and side effects Cote d'Ivoire - epidemiology Cross-Sectional Studies Didanosine Disabilities Disease Distribution Epidemiology Exercise Female Grip strength HIV HIV infections HIV Infections - drug therapy HIV Infections - physiopathology Hospitals Human immunodeficiency virus Humans Infections Life Sciences Male Medical research Medicine and Health Sciences Middle age Middle Aged Nucleoside reverse transcriptase inhibitors Obesity Older people Patients Physical activity Physical Functional Performance Population Postural Balance - physiology Prevalence Risk Factors RNA-directed DNA polymerase Santé publique et épidémiologie Self Report Senegal - epidemiology Standard of Care Stavudine Tropical diseases Zalcitabine Zidovudine |
| title | Prevalence and factors associated with physical function limitation in older West African people living with HIV |
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