Association between serum uric acid and spirometric pulmonary function in Korean adults: The 2016 Korea National Health and Nutrition Examination Survey
A limited number of epidemiological studies have investigated the association between serum uric acid and pulmonary function in the general population. However, the results have been inconclusive. This study was performed to investigate the association between serum uric acid and spirometric pulmona...
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| description | A limited number of epidemiological studies have investigated the association between serum uric acid and pulmonary function in the general population. However, the results have been inconclusive.
This study was performed to investigate the association between serum uric acid and spirometric pulmonary function in general population.
Among the 8,150 participants who participated in the 2016 Korea National Health and Nutrition Examination Survey, 2,901 participants were analyzed in this study. Subjects were divided into four groups according to forced vital capacity (FVC)% predicted or forced expiratory volume in 1 second (FEV1) % predicted quartiles. Participants in the lowest quartile of FVC % predicted and FEV1% predicted were compared to those in the remaining quartiles according to age, education level, household income, smoking status, alcohol consumption, aerobic exercise, obesity, hypertension, diabetes, renal impairment, serum uric acid, and hyperuricemia. Multivariable logistic regression analyses were used to calculate the odds ratio (OR) of hyperuricemia for participants in the lowest quartile of FVC% and FEV1 predicted, with above covariates.
In women, hyperuricemia was associated with lowest quartile of FVC% predicted (OR 1.71, 95% CI 1.06-2.75, p = 0.027) and FEV1 predicted (OR 1.70, 95% CI 1.06-2.74, p = 0.028) respectively, serving as above confounding variables. In men, hyperuricemia (OR 1.54, 95% CI 1.07-2.22, p = 0.021) was associated with the lowest quartile of FEV1% predicted, not FVC% predicted. According to median age, in women, age ≥ 56 years old with hyperuricemia was associated with lowest quartile of FVC% predicted (OR 1.85, 95% CI 1.04-3.28, p = 0.037) and FEV1% predicted (OR 1.99, 95% CI 1.11-3.75, p = 0.021), respectively. In men, age ≥ 56 years old with hyperuricemia was associated with lowest quartile of FEV1% predicted (OR 1.75, 95% CI 1.05-2.94, p = 0.033), not FCV% predicted.
Hyperuricemia was associated with lowest quartile of FEV1% or FVC% predicted in Korean general population. This correlation between hyperuricemia and low pulmonary function was more pronounced in women and older age. |
| doi_str_mv | 10.1371/journal.pone.0240987 |
| format | Article |
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This study was performed to investigate the association between serum uric acid and spirometric pulmonary function in general population.
Among the 8,150 participants who participated in the 2016 Korea National Health and Nutrition Examination Survey, 2,901 participants were analyzed in this study. Subjects were divided into four groups according to forced vital capacity (FVC)% predicted or forced expiratory volume in 1 second (FEV1) % predicted quartiles. Participants in the lowest quartile of FVC % predicted and FEV1% predicted were compared to those in the remaining quartiles according to age, education level, household income, smoking status, alcohol consumption, aerobic exercise, obesity, hypertension, diabetes, renal impairment, serum uric acid, and hyperuricemia. Multivariable logistic regression analyses were used to calculate the odds ratio (OR) of hyperuricemia for participants in the lowest quartile of FVC% and FEV1 predicted, with above covariates.
In women, hyperuricemia was associated with lowest quartile of FVC% predicted (OR 1.71, 95% CI 1.06-2.75, p = 0.027) and FEV1 predicted (OR 1.70, 95% CI 1.06-2.74, p = 0.028) respectively, serving as above confounding variables. In men, hyperuricemia (OR 1.54, 95% CI 1.07-2.22, p = 0.021) was associated with the lowest quartile of FEV1% predicted, not FVC% predicted. According to median age, in women, age ≥ 56 years old with hyperuricemia was associated with lowest quartile of FVC% predicted (OR 1.85, 95% CI 1.04-3.28, p = 0.037) and FEV1% predicted (OR 1.99, 95% CI 1.11-3.75, p = 0.021), respectively. In men, age ≥ 56 years old with hyperuricemia was associated with lowest quartile of FEV1% predicted (OR 1.75, 95% CI 1.05-2.94, p = 0.033), not FCV% predicted.
Hyperuricemia was associated with lowest quartile of FEV1% or FVC% predicted in Korean general population. This correlation between hyperuricemia and low pulmonary function was more pronounced in women and older age.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0240987</identifier><identifier>PMID: 33091060</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Alcohol ; Alcohol use ; Biology and Life Sciences ; Blood pressure ; Body mass index ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Education ; Epidemiology ; Exercise ; Family income ; Female ; Forced Expiratory Volume - physiology ; Heart failure ; Hospitals ; Humans ; Hypertension ; Hyperuricemia ; Hyperuricemia - blood ; Hyperuricemia - complications ; Independent sample ; Kidney diseases ; Lung - physiology ; Male ; Medicine ; Medicine and Health Sciences ; Men ; Middle Aged ; Nutrition ; Nutrition Surveys ; Obesity ; Observations ; Odds Ratio ; Physical fitness ; Physical Sciences ; Physiological aspects ; Polls & surveys ; Population ; Pulmonary functions ; Quartiles ; Regression analysis ; Renal function ; Republic of Korea ; Research and Analysis Methods ; Respiratory function ; Respiratory Function Tests - methods ; Rheumatism ; Risk Factors ; Social Sciences ; Spirometry ; Spirometry - methods ; Uric acid ; Uric Acid - blood ; Vital Capacity - physiology ; Women ; Womens health</subject><ispartof>PloS one, 2020-10, Vol.15 (10), p.e0240987-e0240987</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Hong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Hong et al 2020 Hong et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-7bb24a9e0bf857e5fe96e75ad9a05d5787e13c31424be3d400f43cf541eb731d3</citedby><cites>FETCH-LOGICAL-c692t-7bb24a9e0bf857e5fe96e75ad9a05d5787e13c31424be3d400f43cf541eb731d3</cites><orcidid>0000-0002-5459-097X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580900/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580900/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33091060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Jae Won</creatorcontrib><creatorcontrib>Noh, Jung Hyun</creatorcontrib><creatorcontrib>Kim, Dong-Jun</creatorcontrib><title>Association between serum uric acid and spirometric pulmonary function in Korean adults: The 2016 Korea National Health and Nutrition Examination Survey</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>A limited number of epidemiological studies have investigated the association between serum uric acid and pulmonary function in the general population. However, the results have been inconclusive.
This study was performed to investigate the association between serum uric acid and spirometric pulmonary function in general population.
Among the 8,150 participants who participated in the 2016 Korea National Health and Nutrition Examination Survey, 2,901 participants were analyzed in this study. Subjects were divided into four groups according to forced vital capacity (FVC)% predicted or forced expiratory volume in 1 second (FEV1) % predicted quartiles. Participants in the lowest quartile of FVC % predicted and FEV1% predicted were compared to those in the remaining quartiles according to age, education level, household income, smoking status, alcohol consumption, aerobic exercise, obesity, hypertension, diabetes, renal impairment, serum uric acid, and hyperuricemia. Multivariable logistic regression analyses were used to calculate the odds ratio (OR) of hyperuricemia for participants in the lowest quartile of FVC% and FEV1 predicted, with above covariates.
In women, hyperuricemia was associated with lowest quartile of FVC% predicted (OR 1.71, 95% CI 1.06-2.75, p = 0.027) and FEV1 predicted (OR 1.70, 95% CI 1.06-2.74, p = 0.028) respectively, serving as above confounding variables. In men, hyperuricemia (OR 1.54, 95% CI 1.07-2.22, p = 0.021) was associated with the lowest quartile of FEV1% predicted, not FVC% predicted. According to median age, in women, age ≥ 56 years old with hyperuricemia was associated with lowest quartile of FVC% predicted (OR 1.85, 95% CI 1.04-3.28, p = 0.037) and FEV1% predicted (OR 1.99, 95% CI 1.11-3.75, p = 0.021), respectively. In men, age ≥ 56 years old with hyperuricemia was associated with lowest quartile of FEV1% predicted (OR 1.75, 95% CI 1.05-2.94, p = 0.033), not FCV% predicted.
Hyperuricemia was associated with lowest quartile of FEV1% or FVC% predicted in Korean general population. This correlation between hyperuricemia and low pulmonary function was more pronounced in women and older age.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcohol</subject><subject>Alcohol use</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Education</subject><subject>Epidemiology</subject><subject>Exercise</subject><subject>Family income</subject><subject>Female</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hyperuricemia</subject><subject>Hyperuricemia - blood</subject><subject>Hyperuricemia - complications</subject><subject>Independent sample</subject><subject>Kidney diseases</subject><subject>Lung - physiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Nutrition Surveys</subject><subject>Obesity</subject><subject>Observations</subject><subject>Odds Ratio</subject><subject>Physical fitness</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Polls & surveys</subject><subject>Population</subject><subject>Pulmonary functions</subject><subject>Quartiles</subject><subject>Regression analysis</subject><subject>Renal function</subject><subject>Republic of Korea</subject><subject>Research and Analysis Methods</subject><subject>Respiratory function</subject><subject>Respiratory Function Tests - methods</subject><subject>Rheumatism</subject><subject>Risk Factors</subject><subject>Social Sciences</subject><subject>Spirometry</subject><subject>Spirometry - methods</subject><subject>Uric acid</subject><subject>Uric Acid - blood</subject><subject>Vital Capacity - physiology</subject><subject>Women</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1Fv0zAQxyMEYmPwDRBYQkLw0GLHTpzwgFRNg1VMm8QGr5bjXFpXid3Z8di-CR8XJ-2mFu0BJVKiy-__P9_lLkleEzwllJNPKxucke10bQ1MccpwWfAnySEpaTrJU0yf7rwfJC-8X2Gc0SLPnycHlOKS4BwfJn9m3lulZa-tQRX0vwEM8uBCh4LTCkmlayRNjfxaO9tBPwTXoe2ske4ONcGoUaoN-m4dSINkHdref0ZXS0ApJvkmjs7HFLJFpyDbfjl6nodoN8pPbmWnzeYUl8HdwN3L5FkjWw-vts-j5OfXk6vj08nZxbf58exsovIy7Se8qlImS8BVU2QcsgbKHHgm61LirM54wYFQRQlLWQW0Zhg3jKomYwQqTklNj5K3G991a73YNtWLlGU051nG00jMN0Rt5Uqsne5i5cJKLcaAdQshXa9VC6KQnMWkGIqcMKZyWRcVowWrynjXHEevL9tsoeqgVmB6J9s90_0vRi_Fwt4InhW4xIPBh62Bs9cBfC867RW0rTRgw3huRtKM8yKi7_5BH69uSy1kLECbxsa8ajAVs5yWsXGxr5GaPkLFq4ZOqziBjY7xPcHHPUFkerjtFzJ4L-aXP_6fvfi1z77fYZfjLHnbhmFy_D7INqBy1nsHzUOTCRbDAt13QwwLJLYLFGVvdn_Qg-h-Y-hfbKIXOA</recordid><startdate>20201022</startdate><enddate>20201022</enddate><creator>Hong, Jae Won</creator><creator>Noh, Jung Hyun</creator><creator>Kim, Dong-Jun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5459-097X</orcidid></search><sort><creationdate>20201022</creationdate><title>Association between serum uric acid and spirometric pulmonary function in Korean adults: The 2016 Korea National Health and Nutrition Examination Survey</title><author>Hong, Jae Won ; Noh, Jung Hyun ; Kim, Dong-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-7bb24a9e0bf857e5fe96e75ad9a05d5787e13c31424be3d400f43cf541eb731d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcohol</topic><topic>Alcohol use</topic><topic>Biology and Life Sciences</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Education</topic><topic>Epidemiology</topic><topic>Exercise</topic><topic>Family income</topic><topic>Female</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Heart failure</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hyperuricemia</topic><topic>Hyperuricemia - blood</topic><topic>Hyperuricemia - complications</topic><topic>Independent sample</topic><topic>Kidney diseases</topic><topic>Lung - physiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Nutrition</topic><topic>Nutrition Surveys</topic><topic>Obesity</topic><topic>Observations</topic><topic>Odds Ratio</topic><topic>Physical fitness</topic><topic>Physical Sciences</topic><topic>Physiological aspects</topic><topic>Polls & surveys</topic><topic>Population</topic><topic>Pulmonary functions</topic><topic>Quartiles</topic><topic>Regression analysis</topic><topic>Renal function</topic><topic>Republic of Korea</topic><topic>Research and Analysis Methods</topic><topic>Respiratory function</topic><topic>Respiratory Function Tests - methods</topic><topic>Rheumatism</topic><topic>Risk Factors</topic><topic>Social Sciences</topic><topic>Spirometry</topic><topic>Spirometry - methods</topic><topic>Uric acid</topic><topic>Uric Acid - blood</topic><topic>Vital Capacity - physiology</topic><topic>Women</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Jae Won</creatorcontrib><creatorcontrib>Noh, Jung Hyun</creatorcontrib><creatorcontrib>Kim, Dong-Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Jae Won</au><au>Noh, Jung Hyun</au><au>Kim, Dong-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between serum uric acid and spirometric pulmonary function in Korean adults: The 2016 Korea National Health and Nutrition Examination Survey</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-10-22</date><risdate>2020</risdate><volume>15</volume><issue>10</issue><spage>e0240987</spage><epage>e0240987</epage><pages>e0240987-e0240987</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A limited number of epidemiological studies have investigated the association between serum uric acid and pulmonary function in the general population. However, the results have been inconclusive.
This study was performed to investigate the association between serum uric acid and spirometric pulmonary function in general population.
Among the 8,150 participants who participated in the 2016 Korea National Health and Nutrition Examination Survey, 2,901 participants were analyzed in this study. Subjects were divided into four groups according to forced vital capacity (FVC)% predicted or forced expiratory volume in 1 second (FEV1) % predicted quartiles. Participants in the lowest quartile of FVC % predicted and FEV1% predicted were compared to those in the remaining quartiles according to age, education level, household income, smoking status, alcohol consumption, aerobic exercise, obesity, hypertension, diabetes, renal impairment, serum uric acid, and hyperuricemia. Multivariable logistic regression analyses were used to calculate the odds ratio (OR) of hyperuricemia for participants in the lowest quartile of FVC% and FEV1 predicted, with above covariates.
In women, hyperuricemia was associated with lowest quartile of FVC% predicted (OR 1.71, 95% CI 1.06-2.75, p = 0.027) and FEV1 predicted (OR 1.70, 95% CI 1.06-2.74, p = 0.028) respectively, serving as above confounding variables. In men, hyperuricemia (OR 1.54, 95% CI 1.07-2.22, p = 0.021) was associated with the lowest quartile of FEV1% predicted, not FVC% predicted. According to median age, in women, age ≥ 56 years old with hyperuricemia was associated with lowest quartile of FVC% predicted (OR 1.85, 95% CI 1.04-3.28, p = 0.037) and FEV1% predicted (OR 1.99, 95% CI 1.11-3.75, p = 0.021), respectively. In men, age ≥ 56 years old with hyperuricemia was associated with lowest quartile of FEV1% predicted (OR 1.75, 95% CI 1.05-2.94, p = 0.033), not FCV% predicted.
Hyperuricemia was associated with lowest quartile of FEV1% or FVC% predicted in Korean general population. This correlation between hyperuricemia and low pulmonary function was more pronounced in women and older age.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33091060</pmid><doi>10.1371/journal.pone.0240987</doi><tpages>e0240987</tpages><orcidid>https://orcid.org/0000-0002-5459-097X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-10, Vol.15 (10), p.e0240987-e0240987 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Aged Aged, 80 and over Alcohol Alcohol use Biology and Life Sciences Blood pressure Body mass index Cardiovascular disease Chronic obstructive pulmonary disease Cross-Sectional Studies Diabetes Diabetes mellitus Education Epidemiology Exercise Family income Female Forced Expiratory Volume - physiology Heart failure Hospitals Humans Hypertension Hyperuricemia Hyperuricemia - blood Hyperuricemia - complications Independent sample Kidney diseases Lung - physiology Male Medicine Medicine and Health Sciences Men Middle Aged Nutrition Nutrition Surveys Obesity Observations Odds Ratio Physical fitness Physical Sciences Physiological aspects Polls & surveys Population Pulmonary functions Quartiles Regression analysis Renal function Republic of Korea Research and Analysis Methods Respiratory function Respiratory Function Tests - methods Rheumatism Risk Factors Social Sciences Spirometry Spirometry - methods Uric acid Uric Acid - blood Vital Capacity - physiology Women Womens health |
| title | Association between serum uric acid and spirometric pulmonary function in Korean adults: The 2016 Korea National Health and Nutrition Examination Survey |
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