Carotid artery intima-media thickness, HDL cholesterol levels, and gender associated with poor visual acuity in patients with branch retinal artery occlusion
To investigate factors associated with poor visual acuity (VA) in branch retinal artery occlusion (BRAO). This was a retrospective cross-sectional study of 72 eyes with BRAO of 72 patients. For statistical comparison, we divided the patients into worse-VA (decimal VA < 0.5) and better-VA (decimal...
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| Veröffentlicht in: | PloS one 2020-10, Vol.15 (10), p.e0240977-e0240977 |
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| creator | Yasuda, Masayuki Sato, Hajime Hashimoto, Kazuki Osada, Urara Hariya, Takehiro Nakayama, Hiroko Asano, Toshifumi Suzuki, Noriyuki Okabe, Tatsu Yamazaki, Mai Uematsu, Megumi Munakata, Masanori Nakazawa, Toru |
| description | To investigate factors associated with poor visual acuity (VA) in branch retinal artery occlusion (BRAO).
This was a retrospective cross-sectional study of 72 eyes with BRAO of 72 patients. For statistical comparison, we divided the patients into worse-VA (decimal VA < 0.5) and better-VA (decimal VA > = 0.5) groups. We examined the association of clinical findings, including blood biochemical test data and carotid artery ultrasound parameters, with poor VA.
Median age, hematocrit, hemoglobin and high-density lipoprotein (HDL) differed significantly between the groups (P = 0.018, P < 0.01, P < 0.01, and P = 0.025). There was a tendency towards higher median IMT-Bmax in the worse-VA group (worse-VA vs. better-VA: 2.70 mm vs. 1.60 mm, P = 0.152). Spearman's rank correlation test revealed that logMAR VA was significantly correlated to IMT-Bmax (rs = 0.31, P < 0.01) and IMT-Cmax (rs = 0.24, P = 0.035). Furthermore, logMAR VA was significantly correlated to HDL level (rs = -0.33, P < 0.01). Multivariate logistic regression analysis revealed that IMT-Bmax (odds ratio [OR] = 2.70, P = 0.049), HDL level (OR = 0.91, P = 0.032), and female gender (OR = 15.63, P = 0.032) were independently associated with worse VA in BRAO.
We found that increased IMT-Bmax, decreased HDL, and female sex were associated with poor VA in BRAO patients. Our findings might suggest novel risk factors for visual dysfunction in BRAO and may provide new insights into the pathomechanisms underlying BRAO. |
| doi_str_mv | 10.1371/journal.pone.0240977 |
| format | Article |
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This was a retrospective cross-sectional study of 72 eyes with BRAO of 72 patients. For statistical comparison, we divided the patients into worse-VA (decimal VA < 0.5) and better-VA (decimal VA > = 0.5) groups. We examined the association of clinical findings, including blood biochemical test data and carotid artery ultrasound parameters, with poor VA.
Median age, hematocrit, hemoglobin and high-density lipoprotein (HDL) differed significantly between the groups (P = 0.018, P < 0.01, P < 0.01, and P = 0.025). There was a tendency towards higher median IMT-Bmax in the worse-VA group (worse-VA vs. better-VA: 2.70 mm vs. 1.60 mm, P = 0.152). Spearman's rank correlation test revealed that logMAR VA was significantly correlated to IMT-Bmax (rs = 0.31, P < 0.01) and IMT-Cmax (rs = 0.24, P = 0.035). Furthermore, logMAR VA was significantly correlated to HDL level (rs = -0.33, P < 0.01). Multivariate logistic regression analysis revealed that IMT-Bmax (odds ratio [OR] = 2.70, P = 0.049), HDL level (OR = 0.91, P = 0.032), and female gender (OR = 15.63, P = 0.032) were independently associated with worse VA in BRAO.
We found that increased IMT-Bmax, decreased HDL, and female sex were associated with poor VA in BRAO patients. Our findings might suggest novel risk factors for visual dysfunction in BRAO and may provide new insights into the pathomechanisms underlying BRAO.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0240977</identifier><identifier>PMID: 33091078</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acuity ; Age ; Aged ; Atherosclerosis ; Biology and Life Sciences ; Carotid arteries ; Carotid Arteries - pathology ; Carotid artery ; Carotid Intima-Media Thickness ; Cholesterol ; Cholesterol, HDL - blood ; Correlation ; Creatinine ; Cross-Sectional Studies ; Demographic aspects ; Diagnosis ; Disease ; Evaluation ; Eye (anatomy) ; Eye - pathology ; Female ; Gender ; Health aspects ; Hematocrit ; Hemoglobin ; High density lipoprotein ; High density lipoproteins ; Hospitals ; Humans ; Hypertension ; Male ; Measurement ; Median (statistics) ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Occlusion ; Patients ; Regression analysis ; Retina ; Retinal Artery Occlusion - blood ; Retinal Artery Occlusion - pathology ; Retinal diseases ; Retrospective Studies ; Risk analysis ; Risk factors ; Social Sciences ; Statistical analysis ; Ultrasonic imaging ; Ultrasound ; University graduates ; Vision Disorders - blood ; Vision Disorders - pathology ; Visual acuity ; Visual Acuity - physiology ; Visual aspects</subject><ispartof>PloS one, 2020-10, Vol.15 (10), p.e0240977-e0240977</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Yasuda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Yasuda et al 2020 Yasuda et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e90fcf19ce93495db3a99d549f1a8ec61dfd26b3cea283a00dde738324f4ed773</citedby><cites>FETCH-LOGICAL-c692t-e90fcf19ce93495db3a99d549f1a8ec61dfd26b3cea283a00dde738324f4ed773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580897/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580897/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33091078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nurmohamed, Michael</contributor><creatorcontrib>Yasuda, Masayuki</creatorcontrib><creatorcontrib>Sato, Hajime</creatorcontrib><creatorcontrib>Hashimoto, Kazuki</creatorcontrib><creatorcontrib>Osada, Urara</creatorcontrib><creatorcontrib>Hariya, Takehiro</creatorcontrib><creatorcontrib>Nakayama, Hiroko</creatorcontrib><creatorcontrib>Asano, Toshifumi</creatorcontrib><creatorcontrib>Suzuki, Noriyuki</creatorcontrib><creatorcontrib>Okabe, Tatsu</creatorcontrib><creatorcontrib>Yamazaki, Mai</creatorcontrib><creatorcontrib>Uematsu, Megumi</creatorcontrib><creatorcontrib>Munakata, Masanori</creatorcontrib><creatorcontrib>Nakazawa, Toru</creatorcontrib><title>Carotid artery intima-media thickness, HDL cholesterol levels, and gender associated with poor visual acuity in patients with branch retinal artery occlusion</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To investigate factors associated with poor visual acuity (VA) in branch retinal artery occlusion (BRAO).
This was a retrospective cross-sectional study of 72 eyes with BRAO of 72 patients. For statistical comparison, we divided the patients into worse-VA (decimal VA < 0.5) and better-VA (decimal VA > = 0.5) groups. We examined the association of clinical findings, including blood biochemical test data and carotid artery ultrasound parameters, with poor VA.
Median age, hematocrit, hemoglobin and high-density lipoprotein (HDL) differed significantly between the groups (P = 0.018, P < 0.01, P < 0.01, and P = 0.025). There was a tendency towards higher median IMT-Bmax in the worse-VA group (worse-VA vs. better-VA: 2.70 mm vs. 1.60 mm, P = 0.152). Spearman's rank correlation test revealed that logMAR VA was significantly correlated to IMT-Bmax (rs = 0.31, P < 0.01) and IMT-Cmax (rs = 0.24, P = 0.035). Furthermore, logMAR VA was significantly correlated to HDL level (rs = -0.33, P < 0.01). Multivariate logistic regression analysis revealed that IMT-Bmax (odds ratio [OR] = 2.70, P = 0.049), HDL level (OR = 0.91, P = 0.032), and female gender (OR = 15.63, P = 0.032) were independently associated with worse VA in BRAO.
We found that increased IMT-Bmax, decreased HDL, and female sex were associated with poor VA in BRAO patients. Our findings might suggest novel risk factors for visual dysfunction in BRAO and may provide new insights into the pathomechanisms underlying BRAO.</description><subject>Acuity</subject><subject>Age</subject><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Biology and Life Sciences</subject><subject>Carotid arteries</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid artery</subject><subject>Carotid Intima-Media Thickness</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Correlation</subject><subject>Creatinine</subject><subject>Cross-Sectional Studies</subject><subject>Demographic aspects</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Evaluation</subject><subject>Eye (anatomy)</subject><subject>Eye - pathology</subject><subject>Female</subject><subject>Gender</subject><subject>Health aspects</subject><subject>Hematocrit</subject><subject>Hemoglobin</subject><subject>High density lipoprotein</subject><subject>High density lipoproteins</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Measurement</subject><subject>Median (statistics)</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Occlusion</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Retina</subject><subject>Retinal Artery Occlusion - blood</subject><subject>Retinal Artery Occlusion - pathology</subject><subject>Retinal diseases</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Social Sciences</subject><subject>Statistical analysis</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><subject>University graduates</subject><subject>Vision Disorders - blood</subject><subject>Vision Disorders - pathology</subject><subject>Visual acuity</subject><subject>Visual Acuity - physiology</subject><subject>Visual aspects</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9GAIArumkxmM5MbodSPFgoFv27DmeTMTmp2siaZan-M_9VMd1u60gvJRcLJc96cvMkpiqeMzhmv2dtzP4YB3HztB5zTsqKyru8V-0zyciZKyu_fWu8Vj2I8p3TBGyEeFnucU8lo3ewXf44g-GQNgZAwXBI7JLuC2QqNBZJ6q38MGOMbcvz-lOjeO4wZ8444vECX4zAYssTBYCAQo9cWEhryy6aerL0P5MLGERwBPdo0qZM1JItDihumDTDongRMdpiwTRFeazdG64fHxYMOXMQn2_mg-Pbxw9ej49np2aeTo8PTmRayTDOUtNMdkxolr-TCtBykNItKdgwa1IKZzpSi5RqhbDhQagzWvOFl1VVo6pofFM83umvno9o6G1VZLbioF0w0mTjZEMbDuVqHbFK4VB6sugr4sFS5eKsdqqZpGaVdV8pSVAI6CdiyVkiKhjYodNZ6tz1tbLPROtsRwO2I7u4MtldLf6HqRUMbOZX7aisQ_M8xP4la2ajRORjQj1d1V6xsBJ3QF_-gd99uSy0hX8AOnc_n6klUHQouWZVtKzM1v4PKw-DK6vwNO5vjOwmvdxIyk_B3WsIYozr58vn_2bPvu-zLW2yP4FIfvRtT_jJxF6w2oA4-xoDdjcmMqqmLrt1QUxepbRfltGe3H-gm6bpt-F_rhxtB</recordid><startdate>20201022</startdate><enddate>20201022</enddate><creator>Yasuda, Masayuki</creator><creator>Sato, Hajime</creator><creator>Hashimoto, Kazuki</creator><creator>Osada, Urara</creator><creator>Hariya, Takehiro</creator><creator>Nakayama, Hiroko</creator><creator>Asano, Toshifumi</creator><creator>Suzuki, Noriyuki</creator><creator>Okabe, Tatsu</creator><creator>Yamazaki, Mai</creator><creator>Uematsu, Megumi</creator><creator>Munakata, Masanori</creator><creator>Nakazawa, Toru</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20201022</creationdate><title>Carotid artery intima-media thickness, HDL cholesterol levels, and gender associated with poor visual acuity in patients with branch retinal artery occlusion</title><author>Yasuda, Masayuki ; Sato, Hajime ; Hashimoto, Kazuki ; Osada, Urara ; Hariya, Takehiro ; Nakayama, Hiroko ; Asano, Toshifumi ; Suzuki, Noriyuki ; Okabe, Tatsu ; Yamazaki, Mai ; Uematsu, Megumi ; Munakata, Masanori ; Nakazawa, Toru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-e90fcf19ce93495db3a99d549f1a8ec61dfd26b3cea283a00dde738324f4ed773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acuity</topic><topic>Age</topic><topic>Aged</topic><topic>Atherosclerosis</topic><topic>Biology and Life Sciences</topic><topic>Carotid arteries</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid artery</topic><topic>Carotid Intima-Media Thickness</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Correlation</topic><topic>Creatinine</topic><topic>Cross-Sectional Studies</topic><topic>Demographic aspects</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>Evaluation</topic><topic>Eye (anatomy)</topic><topic>Eye - pathology</topic><topic>Female</topic><topic>Gender</topic><topic>Health aspects</topic><topic>Hematocrit</topic><topic>Hemoglobin</topic><topic>High density lipoprotein</topic><topic>High density lipoproteins</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Measurement</topic><topic>Median (statistics)</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Occlusion</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Retina</topic><topic>Retinal Artery Occlusion - blood</topic><topic>Retinal Artery Occlusion - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasuda, Masayuki</au><au>Sato, Hajime</au><au>Hashimoto, Kazuki</au><au>Osada, Urara</au><au>Hariya, Takehiro</au><au>Nakayama, Hiroko</au><au>Asano, Toshifumi</au><au>Suzuki, Noriyuki</au><au>Okabe, Tatsu</au><au>Yamazaki, Mai</au><au>Uematsu, Megumi</au><au>Munakata, Masanori</au><au>Nakazawa, Toru</au><au>Nurmohamed, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carotid artery intima-media thickness, HDL cholesterol levels, and gender associated with poor visual acuity in patients with branch retinal artery occlusion</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-10-22</date><risdate>2020</risdate><volume>15</volume><issue>10</issue><spage>e0240977</spage><epage>e0240977</epage><pages>e0240977-e0240977</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To investigate factors associated with poor visual acuity (VA) in branch retinal artery occlusion (BRAO).
This was a retrospective cross-sectional study of 72 eyes with BRAO of 72 patients. For statistical comparison, we divided the patients into worse-VA (decimal VA < 0.5) and better-VA (decimal VA > = 0.5) groups. We examined the association of clinical findings, including blood biochemical test data and carotid artery ultrasound parameters, with poor VA.
Median age, hematocrit, hemoglobin and high-density lipoprotein (HDL) differed significantly between the groups (P = 0.018, P < 0.01, P < 0.01, and P = 0.025). There was a tendency towards higher median IMT-Bmax in the worse-VA group (worse-VA vs. better-VA: 2.70 mm vs. 1.60 mm, P = 0.152). Spearman's rank correlation test revealed that logMAR VA was significantly correlated to IMT-Bmax (rs = 0.31, P < 0.01) and IMT-Cmax (rs = 0.24, P = 0.035). Furthermore, logMAR VA was significantly correlated to HDL level (rs = -0.33, P < 0.01). Multivariate logistic regression analysis revealed that IMT-Bmax (odds ratio [OR] = 2.70, P = 0.049), HDL level (OR = 0.91, P = 0.032), and female gender (OR = 15.63, P = 0.032) were independently associated with worse VA in BRAO.
We found that increased IMT-Bmax, decreased HDL, and female sex were associated with poor VA in BRAO patients. Our findings might suggest novel risk factors for visual dysfunction in BRAO and may provide new insights into the pathomechanisms underlying BRAO.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33091078</pmid><doi>10.1371/journal.pone.0240977</doi><tpages>e0240977</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-10, Vol.15 (10), p.e0240977-e0240977 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2453675168 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acuity Age Aged Atherosclerosis Biology and Life Sciences Carotid arteries Carotid Arteries - pathology Carotid artery Carotid Intima-Media Thickness Cholesterol Cholesterol, HDL - blood Correlation Creatinine Cross-Sectional Studies Demographic aspects Diagnosis Disease Evaluation Eye (anatomy) Eye - pathology Female Gender Health aspects Hematocrit Hemoglobin High density lipoprotein High density lipoproteins Hospitals Humans Hypertension Male Measurement Median (statistics) Medicine Medicine and Health Sciences Middle Aged Occlusion Patients Regression analysis Retina Retinal Artery Occlusion - blood Retinal Artery Occlusion - pathology Retinal diseases Retrospective Studies Risk analysis Risk factors Social Sciences Statistical analysis Ultrasonic imaging Ultrasound University graduates Vision Disorders - blood Vision Disorders - pathology Visual acuity Visual Acuity - physiology Visual aspects |
| title | Carotid artery intima-media thickness, HDL cholesterol levels, and gender associated with poor visual acuity in patients with branch retinal artery occlusion |
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