Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients

COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared throughout the World and currently affected more than 9 million people and caused the death of around 470,000 patients. The novel strain of the coronavirus disease is transmittable at a devastating rate with a high rat...

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Veröffentlicht in:	PloS one 2020-10, Vol.15 (10), p.e0240012
Hauptverfasser:	Akgun, Emel, Tuzuner, Mete Bora, Sahin, Betul, Kilercik, Meltem, Kulah, Canan, Cakiroglu, Hacer Nur, Serteser, Mustafa, Unsal, Ibrahim, Baykal, Ahmet Tarik
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adult Antiinfectives and antibacterials Antimicrobial peptides Betacoronavirus - genetics Biochemistry Biology and Life Sciences CAP37 protein Cathepsin G Cell Degranulation - immunology Chromatography, Liquid - methods Confidence Coronaviridae Coronavirus Infections - immunology Coronavirus Infections - virology Coronaviruses COVID-19 Degranulation Demographic aspects Diagnosis Distribution Elastase Enzymes Female Humans Immune system Infections Innate immunity Male Medical laboratories Medicine Medicine and Health Sciences Middle Aged Nasopharynx - virology Neutrophil Activation - immunology Neutrophils Neutrophils - immunology Older people Pandemics Peptides Peroxidase Pharynx Physiological aspects Pneumonia, Viral - immunology Pneumonia, Viral - virology Protein interaction Protein Interaction Maps Proteins Proteome Proteomics Proteomics - methods Real-Time Polymerase Chain Reaction Respiratory diseases RNA polymerase SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Statistical analysis Statistical methods Tandem Mass Spectrometry - methods Up-Regulation Viral diseases Viral infections Viral proteins Young Adult
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