Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells

The two T-box transcription factors T-bet and Eomesodermin (Eomes) are important regulators of cytotoxic lymphocytes (CTLs), such as activated CD8 T cells, which are essential in the fight against intracellular pathogens and tumors. Both transcription factors share a great degree of homology based o...

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Veröffentlicht in:	PLoS pathogens 2020-09, Vol.16 (9), p.e1008870
Hauptverfasser:	Fixemer, Jonas, Hummel, Jonas F, Arnold, Frederic, Klose, Christoph S. N, Hofherr, Alexis, Weissert, Kristoffer, Kögl, Tamara, Köttgen, Michael, Arnold, Sebastian J, Aichele, Peter, Tanriver, Yakup
Format:	Artikel
Sprache:	eng
Schlagworte:	Attorneys Authorship Biology and Life Sciences CD8 antigen Cell differentiation Chronic infection Cytokines Cytotoxicity Differentiation (biology) Effector cells Exhaustion Funding Gene expression Genetic aspects Health aspects Homology Hygiene Infections Infectious diseases Internal medicine Kinases Lymphocytes Lymphocytes T Medicine Medicine and Health Sciences Pathogens Redundancy Regulators Research and Analysis Methods Sequence analysis Supervision T cell receptors T cells Transcription factors Tumors Viral infections Viruses
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