The gammaherpesviral TATA-box-binding protein directly interacts with the CTD of host RNA Pol II to direct late gene transcription

β- and γ-herpesviruses include the oncogenic human viruses Kaposi's sarcoma-associated virus (KSHV) and Epstein-Barr virus (EBV), and human cytomegalovirus (HCMV), which is a significant cause of congenital disease. Near the end of their replication cycle, these viruses transcribe their late ge...

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Veröffentlicht in:	PLoS pathogens 2020-09, Vol.16 (9), p.e1008843-e1008843
Hauptverfasser:	Castañeda, Angelica F, Didychuk, Allison L, Louder, Robert K, McCollum, Chloe O, Davis, Zoe H, Nogales, Eva, Glaunsinger, Britt A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs BASIC BIOLOGICAL SCIENCES Binding proteins Biology Biology and life sciences Biophysics Conserved sequence Deoxyribonucleic acid DNA DNA-directed RNA polymerase Domains Electron microscopy Epstein-Barr virus Gene expression Genetic aspects Health aspects HEK293 Cells Herpesvirus 8, Human - genetics Herpesvirus 8, Human - metabolism Herpesviruses Homology Host-virus relationships Humans Kaposi's sarcoma Laboratories Mutation Phosphorylation Physiological aspects Protein Binding Protein Domains Proteins Recruitment Research and Analysis Methods Ribonucleic acid RNA RNA polymerase RNA polymerase II RNA Polymerase II - genetics RNA Polymerase II - metabolism RNA polymerases Sarcoma TATA-binding protein TATA-Box Binding Protein - genetics TATA-Box Binding Protein - metabolism Transcription Transcription (Genetics) Transcription factors Viral Proteins - genetics Viral Proteins - metabolism Viral research Viruses
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